Le Wang
Boston University
SignalOpticsPolaritonCantileverMicroscopyInfrared spectroscopyInfraredNanotechnologyPhotothermal therapyChemistryScatteringMaterials scienceImage resolutionPhononNear and far fieldCharacterization (materials science)Infrared microscopyHexagonal boron nitrideNanoscopic scaleOptoelectronicsLaserSurface phononChemical imagingResolution (electron density)Optical microscopeExcitation
18Publications
6H-index
156Citations
Publications 16
Newest
#1Yi Zhang (BU: Boston University)H-Index: 4
#2Celalettin Yurdakul (BU: Boston University)H-Index: 7
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 8 authors...
We report a confocal interferometric mid-infrared photothermal (MIP) microscope for ultra-sensitive and spatially resolved chemical imaging of individual viruses. The interferometric scattering principle is applied to detect the very weak photothermal signal induced by infrared absorption of chemical bonds. Spectroscopic MIP detection of single vesicular stomatitis viruses (VSVs) and poxviruses is demonstrated. The single virus spectra show high consistency within the same virus type. The domina...
7 CitationsSource
#1X Cao (Inner Mongolia Medical University)
#2H-M WangH-Index: 1
Last. Z-F She
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OBJECTIVE The purpose of this study was to establish a nomogram for predicting the severity of acute pancreatitis (AP) and verify its predictive value. PATIENTS AND METHODS A total of 571 AP patients received by Ordos Central Hospital from January 2015 to December 2018 were included in this study. According to the 2012 Revised Atlanta classification, the included subjects were classified into severe AP (SAP) group and non-severe AP (NSAP) group [including patient with mild AP (MAP) and moderatel...
Source
#1Haomin Wang (Lehigh University)H-Index: 28
#2Le Wang (Lehigh University)H-Index: 6
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 5 authors...
Total internal reflection (TIR) infrared spectroscopy is a convenient measurement tool for collecting spectra for chemical identification. However, TIR infrared microscopy lacks high spatial resolution due to the optical diffraction limit and difficulty to preserve a high-quality wave front for focus. In this article, we present the peak force infrared microscopy in the TIR geometry to achieve a 10 nm spatial resolution. Instead of optical detection, photothermal responses of the sample are coll...
1 CitationsSource
#1Haomin Wang (Lehigh University)H-Index: 28
#2Le Wang (Lehigh University)H-Index: 6
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 8 authors...
Optical responses of molecules and materials provide a basis for chemical measurement and imaging. The optical diffraction limit in conventional light microscopy is exceeded by mechanically probing optical absorption through the photothermal effect with atomic force microscopy (AFM). However, the spatial resolution of AFM-based photothermal optical microscopy is still limited, and the sample surface is prone to damage from scratching due to tip contact, particularly for measurements on soft matt...
Source
#1Haomin Wang (Lehigh University)H-Index: 28
#2Eli Janzen (KSU: Kansas State University)H-Index: 1
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 5 authors...
Phonon polaritons (PhPs), the collective phonon oscillations with hybridized electromagnetic fields, concentrate optical fields in the mid-infrared frequency range that matches the vibrational modes of molecules. The utilization of PhPs holds the promise for chemical sensing tools and polariton-enhanced nanospectroscopy. However, investigations and innovations on PhPs in the aqueous phase remains stagnant, because of the lack of in situ mid-infrared nano-imaging methods in water. Strong infrared...
10 CitationsSource
#1Le Wang (Lehigh University)H-Index: 6
#2Martin WagnerH-Index: 21
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 7 authors...
Source
#1Le Wang (Lehigh University)H-Index: 6
#2Martin WagnerH-Index: 21
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 7 authors...
7 CitationsSource
#1Le Wang (Lehigh University)H-Index: 6
#2Devon S. Jakob (Lehigh University)H-Index: 5
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 6 authors...
Infrared chemical microscopy through mechanical probing of light–matter interactions by atomic force microscopy (AFM) bypasses the diffraction limit. One increasingly popular technique is photoinduced force microscopy (PiFM), which utilizes the mechanical heterodyne signal detection between cantilever mechanical resonant oscillations and the photoinduced force from the light–matter interaction. So far, PiFM has been operated in only one heterodyne configuration. In this Article, we generalize he...
8 CitationsSource
#1Devon S. Jakob (Lehigh University)H-Index: 5
#2Le Wang (Lehigh University)H-Index: 6
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 4 authors...
In situmeasurements of the chemical compositions and mechanical properties of kerogen help understand the formation, transformation, and utilization of organic matter in oil shale source rocks. However, the optical diffraction limit prevents attainment of nanoscale resolution using conventional spectroscopy and microscopy. Here, we developed peak force infrared (PFIR) microscopy for multimodal characterization of kerogen in organic shales. PFIR microscopy provides correlative infrared imaging, m...
23 CitationsSource
#1Le Wang (Lehigh University)H-Index: 6
#2Haomin Wang (Lehigh University)H-Index: 28
Last. Xiaoji G. Xu (Lehigh University)H-Index: 15
view all 4 authors...
Measurement of photoinduced mechanical responses by atomic force microscopy (AFM) because of sample infrared resonances enables chemical-sensitive microscopy with spatial resolution orders of magnitude better than the optical diffraction limit. However, the origin of noncontact photoinduced force between the AFM tip and the samples of infrared resonances is still under debate. To investigate its origin, we implemented synchronized infrared pulse excitation and mechanical detection with a station...
8 CitationsSource