Yubo Li
Tianjin University of Traditional Chinese Medicine
NephrotoxicityInternal medicineMass spectrometryHigh-performance liquid chromatographyChemistryTraditional Chinese medicineMetabolic pathwayIn vivoMetabolomicsOxidative stressFatty acid metabolismFormic acidCardiotoxicityUrineToxicityChemical constituentsUplc q tof msChromatographyBiochemistryMetabolismMedicinePharmacology
73Publications
15H-index
586Citations
Publications 72
Newest
#1Jinxia Wei (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Jia Shao (Tianjin First Center Hospital)H-Index: 1
Last. Yubo Li (Tianjin University of Traditional Chinese Medicine)H-Index: 15
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To investigate the pharmacokinetics of 6-O-demethylmenisporphine, an oxoisoaporphine alkaloid with significant anti-tumor activities and isolated from Menispermi Rhizoma, a novel and sensitive HPLC assay was established for 6-O-demethylmenisporphine quantification in rat plasma. Peak responses were detected by a highly selective and sensitive fluorescence detector with 426-nm excitation and 514-nm emission wavelengths. Curcumin was employed as the internal standard (IS). A Capcell Pak C18 column...
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#1Pengwei Zhuang (Tianjin University of Traditional Chinese Medicine)H-Index: 13
#2Lijuan Xie (Tianjin University of Traditional Chinese Medicine)H-Index: 3
Last. Yanjun Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 17
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Abstract null null Cutaneous eruptions caused by the combination of aspirin (ASA) and Shuanghuanglian preparations have attracted widespread attention; however, the underlying mechanism remains unclear. This study aimed to evaluate the potential mechanism of cutaneous eruptions caused by a combination of Shuanghuanglian injection powder (SHL) and ASA in vivo and in vitro. ASA and SHL co-administration induced inflammatory responses in HaCat cells, as evidenced by marked increases in the expressi...
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#1Shan-Ze LiH-Index: 1
#2Yuming Wang (Tianjin University of Traditional Chinese Medicine)H-Index: 6
Last. Yubo Li
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Background Rhubarb, as a traditional Chinese medicine, is the preferred drug for the treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism in vivo is still unclear. Methods In this study, the chemical components in rhubarb were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology. The metabolic biomarkers obtained through metabolomics technology were related to rhubarb-induced hepatot...
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#1Dandan Shen (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Huan Zhao (Tianjin University of Traditional Chinese Medicine)H-Index: 6
Last. Chunquan Yu (Tianjin University of Traditional Chinese Medicine)H-Index: 5
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Abstract Background Fluoxetine hydrochloride is one of the familiar antidepressants of the second generation and has the effect of inhibiting the reuptake of 5-hydroxytryptamine by central nervous system. Both clinical trials and animal experiments show that it has good antidepressant effect, but there are few reports on its clinical efficacy in treating depression patients from the perspective of metabolomics. This study aimed at evaluating the antidepressant effect of fluoxetine hydrochloride ...
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#1Shenshen Yang (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#1Shenshen Yang (Tianjin University of Traditional Chinese Medicine)H-Index: 2
Last. Yubo Li (Tianjin University of Traditional Chinese Medicine)H-Index: 15
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INTRODUCTION Radix Paeoniae Alba (RPA) presents several pharmacological effects, including analgesia, liver protection, and toxicity reduction. RPA consists mostly of monoterpenes and their glycosides, tannins, flavonoids, and organic acids, with monoterpenes being the main active pharmaceutical ingredients. OBJECTIVE To establish an effective method for rapid classification and identification of the main monoterpenes, flavonoids, and organic acids in RPA. METHODS We used ultrahigh-performance l...
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#1Ziyi Jiao (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Huan Zhao (Tianjin University of Traditional Chinese Medicine)H-Index: 6
Last. Chun-Quan Yu (Tianjin University of Traditional Chinese Medicine)H-Index: 3
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Depression is a mental disorder characterized by persistent unhappiness, lack of interest, with cognitive and sleep disorders. Jiaotaiwan is a traditional Chinese medicine for the treatment of insomnia and depressive-like symptoms. In this study, the major chemical components in Jiaotaiwan were qualitatively analyzed using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry, and a model of depression in rats was subsequently established with chronic unpredictable ...
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#1Yu YuanH-Index: 3
#2Simiao FanH-Index: 6
Last. Yubo LiH-Index: 15
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Heart failure is a common systemic disease with high morbidity and mortality worldwide. Doxorubicin (DOX) is a commonly used anthracycline broad-spectrum antitumor antibiotic with strong antitumor effect and definite curative effect. However, cardiotoxicity is the adverse reaction of drug dose cumulative toxicity, but the mechanism is still unclear. In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to cl...
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#1Chenghao Bi (Tianjin University of Traditional Chinese Medicine)H-Index: 2
#2Tianpu Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 5
Last. Yanjun Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 17
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Currently, research on cardiac injury by aconitine focuses on its effect to directly interfere with the function of cardiac ion channels. Further, abnormal lipid metabolism could cause cardiac injury via inflammatory signaling pathway. In our preliminary study, we discovered that aconitine could alter the metabolism processes of various substances, including palmitic acid. Inspired by these studies, we investigated how elevation of palmitic acid by aconitine causes cardiac injury. Aconitine indu...
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#1Ying Li (Tianjin University of Traditional Chinese Medicine)H-Index: 2
#2Xing Wang (Tianjin University of Traditional Chinese Medicine)H-Index: 2
Last. Yubo Li (Tianjin University of Traditional Chinese Medicine)H-Index: 15
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Abstract As a generally edible plant, Ixeris denticulata (Houtt.) Stebb is widely distributed in China. Its medicinal value has attracted much attention in recent years. However, the chemical markers that cause quality and taste differences in I. denticulata from different regions are currently unclear. In this study, samples from 8 different origins were collected and analysed by UPLC-Q-TOF/MS. A metabolomics data processing strategy and machine learning method were established to explore the r...
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#1Ning Li (Tianjin Medical University)
#2Lijuan Xie (Tianjin University of Traditional Chinese Medicine)H-Index: 3
Last. Yubo Li (Tianjin University of Traditional Chinese Medicine)H-Index: 15
view all 11 authors...
Introduction Epimedium koreanum Nakai (EKN), is a well-known Chinese herbal medicine for the treatment of osteoporosis, immunosuppression, tumours and cardiovascular diseases. Comprehensive component identification is essential for elucidation of its pharmacological mechanism and quality control. However, its complex chemical composition has caused certain difficulties in the analysis of this traditional Chinese medicine (TCM). Therefore, there is an urgent need to establish a method for rapid c...
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