Qiao Wang
Hebei Medical University
AnalytePharmacokineticsAnalytical chemistryDetection limitMass spectrometryHigh-performance liquid chromatographyChemistryElectrosprayRadixIn vivoMetabolomicsFormic acidQuadrupole ion trapTandem mass spectrometryElectrospray ionizationChromatographyLiquid chromatography–mass spectrometrySelected reaction monitoringElutionProtein precipitation
71Publications
19H-index
924Citations
Publications 71
Newest
#1Honghong Jiang (Hebei Medical University)H-Index: 4
#2Wendan Zhang (SHU: Shanghai University)
Last. Huijun Xu (Hebei Medical University)H-Index: 14
view all 9 authors...
A simple, sensitive and efficient solid-phase extraction method, combined with ultrahigh-performance liquid chromatography-charged aerosol detection, was applied to the pre-concentration and determination of four triterpenoid saponins from Pulsatilla chinensis (P. chinensis) ultrasound extract samples. Mesoporous molecular sieve Santa Barbara Amorphous 15 (SBA-15) displayed higher selectivity compared to Mobil Composition of Matter 41 (MCM-41), NH2-SBA-15 and mesoporous carbon when it comes to b...
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#1Guanhua Zhang (Hebei Medical University)H-Index: 2
#2Qi Wang (Hebei Medical University)H-Index: 2
Last. Qiao Wang (Hebei Medical University)H-Index: 19
view all 10 authors...
Abstract The “multi-component and multi-target” property of traditional Chinese medicine (TCM) makes the quality control more difficult, which remains a key concern hindering the space of progress in its modernization and globalization. This study aims to provide a new strategy to discover quality markers related to the efficacy and stability of TCM based on the bioactive markers finding and differential markers finding, Guan-Xin-Jing capsule (GXJC) was used as a model. Firstly, the UHPLC-QTOF-M...
1 CitationsSource
#1Jie Zhao (Hebei Medical University)H-Index: 1
#1Jie Zhao (Hebei Medical University)H-Index: 15
Last. Frank J. GonzalezH-Index: 190
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Abstract Triptolide, a major active component of Triptergium wilfordii Hook. f, is used in the treatment of autoimmune disease. However, triptolide is associated with severe adverse reactions, especially hepatotoxicity, which limits its clinical application. To examine the underlying mechanism of triptolide-induced liver injury, a combination of dose- and time-dependent toxic effects, RNA-seq and metabolomics were employed. Triptolide-induced toxicity occurred in a dose- and time-dependent manne...
1 CitationsSource
#1Wendan Zhang (Hebei Medical University)H-Index: 6
#2Yu Chen (Hebei Medical University)H-Index: 1
Last. Huijun Xu (Hebei Medical University)H-Index: 14
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Abstract Screening diagnostic biomarkers can be challenging due to the complexity of traditional Chinese medicine (TCM) and ambiguous pharmacological mechanisms. In this study, we reported an integrated strategy for accurately screening diagnostic biomarkers based on metabolomics coupled with network pharmacology. First, a feasible pharmacological model was established through systems pharmacology and based on metabolomics-based techniques to explore diagnostic biomarkers. While the components s...
9 CitationsSource
#1Xu Wang (Hebei Medical University)H-Index: 2
#2Gao Yanhua (Hebei Medical University)H-Index: 1
Last. Qiao Wang (Hebei Medical University)H-Index: 19
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Abstract Ethnopharmacological relevance Ling-Gui-Zhu-Gan Decoction (LGZGD) formula, derived from traditional Chinese medicine (TCM), has definitive clinical efficacy in the treatment of heart failure (HF) in China. However, little is known of the underlying mechanism of LGZGD. Aim of the study The aim of this work was to investigate the therapeutic mechanism of LGZGD on HF treatment based on an integration of the serum metabolomics and network analysis. Materials and methods HF model mice were e...
5 CitationsSource
#1Honghong Jiang (Hebei Medical University)H-Index: 4
#2Jianxi Yang (Hebei Medical University)H-Index: 3
Last. Huijun Xu (Hebei Medical University)H-Index: 14
view all 8 authors...
INTRODUCTION: Hederacoside C (HDC) is a bioactive natural triterpenoid saponins constituent originating from traditional Chinese medicines, playing an important role in the treatment of acute respiratory infections and chronic inflammatory bronchitis. Meanwhile, it is recognised by Korea as a botanical drug. OBJECTIVES: In order to develop an integrated template approach to analysing screening and identification of the metabolites of traditional Chinese medicines. This study will provide availab...
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#1Ludan Hou (Hebei Medical University)H-Index: 4
#2Shuai Guan (Hebei Medical University)H-Index: 2
Last. Rong Zhang (Hebei Medical University)H-Index: 2
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Abstract Carbon black nanoparticles (CBNPs) are core component of fine particulate matter (PM2.5) in the atmosphere. It was reported that the particle in the atmosphere with smaller size and the larger the specific surface area are easier to reach the deep respiratory tract or even the alveoli through the respiratory barrier and cause lung injury. Therefore, it has been believed that ultrafine or nanometer particles with more toxic than those with larger particle sizes. Moreover, it was confirme...
3 CitationsSource
#1Xiyan Mu (Hebei Medical University)H-Index: 3
#2Chuanyuan JiH-Index: 1
Last. Yangang WangH-Index: 1
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Abstract Analysis of the properties of the tongue has been used in traditional Chinese medicine for disease diagnosis. Notably, tongue analysis, which is non-invasive and convenient compared with gastroscopy and pathological examination, can be used to assess chronic gastritis (CG). In order to find potential diagnostic biomarkers and study the metabolic mechanisms of the endogenous small molecules in the tongue coating related to CG, a non-targeted metabolomic analysis method was developed usin...
2 CitationsSource
#1Guanhua Zhang (Hebei Medical University)H-Index: 2
#2Hongxia Wang (Hebei Medical University)H-Index: 2
Last. Qiao Wang (Hebei Medical University)H-Index: 19
view all 9 authors...
Abstract Poria cocos (Schw.) Wolf (PCW) is a widely used traditional Chinese medicine and dietary supplement. Its four parts including Poriae Cutis (PC), Rubra Poria (RP), White Poria (WP) and Poria cum Radix Pini (PRP) have different pharmacological effects and clinical applications. It is necessary to establish analytical platforms for differentiating the chemical composition of four botanical parts for the rational utilization. We established a simultaneous qualitative and quantitative method...
6 CitationsSource
#1Caifeng Meng (Hebei Medical University)H-Index: 2
#2Qingjie Han (Hebei Medical University)H-Index: 3
Last. Chunying Wang (Hebei Medical University)H-Index: 8
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: A hybrid quadruple linear ion trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) analytical method has been developed for simultaneous determination of 13 nucleosides from Cordyceps cicadae and Cordyceps sinensis for assessing whether C. cicadae can become a substitute for C. sinensis, based on that C. cicadae has in common with C. sinensis for treating chronic diseases. Among the 13 compounds, three compounds including cytidine, hypoxanthine and 2'-deoxyguanosine were firstly iden...
1 CitationsSource