Dimitri Arangalage
Paris Diderot University
Internal medicineRadiologySurgeryMagnetic resonance imagingRenal functionCardiologyHemodynamicsProspective cohort studyPredictive value of testsAsymptomaticHeart failureCoronary artery diseaseStenosisMyocarditisAortic valve stenosisPopulationCalcific aortic valve stenosisAcute myocarditisAortic valve areaAortic valve calcificationSudden deathFirst passMedicineEjection fraction
Publications 21
#1Dimitri ArangalageH-Index: 7
#1Dimitri Arangalage (CHUV: University Hospital of Lausanne)
Last. David Messika-Zeitoun (U of O: University of Ottawa)H-Index: 38
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ABSTRACT Background The contribution of exercise echocardiography in primary asymptomatic mitral regurgitation (MR) remains debated. We aimed to gain evidence regarding its usefulness in this setting, and investigate the prognostic value of peak exercise systolic pulmonary artery pressure (SPAP). Methods We identified 177 patients (56±13 years, 69% males) with moderate-to-severe (3+)/severe (4+) degenerative MR and preserved left ventricular ejection fraction (LVEF), in sinus rhythm, referred fo...
#1Branka Vulesevic (U of O: University of Ottawa)H-Index: 23
#2Naozumi Kubota (Juntendo University)H-Index: 11
Last. David Messika-Zeitoun (U of O: University of Ottawa)H-Index: 38
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AIMS Severe aortic valve stenosis (AS) is defined by an aortic valve area (AVA) 0.79) but greater with AVA/H. Regressions lines were markedly different in obese and non-obese patients with AVA/BSA (P < 0.0001) but almost identical with AVA/H (P = 0.16). AVA/BSA values that corresponded to an AVA of 1.0 cm2 were markedly different in obese and non-obese patients (0.48 and 0.59 cm2/m2) but not with AVA/H (0.61 cm2/m for both). Agreement for the diagnosis of severe AS (AVA < 1 cm2) was significantl...
#1Branka VulesevicH-Index: 23
#2Ian G. BurwashH-Index: 30
Last. David Messika-ZeitounH-Index: 38
view all 12 authors...
Severe aortic stenosis (AS) is defined by a peak velocity (PV) of ≥4 m/s, a mean pressure gradient (MPG) of ≥40 mm Hg, and an aortic valve area (AVA) of <1.0 cm2 ([1][1]). However, these parameters are often discordant (AVA <1.0 cm2 and MPG <40 mm Hg or AVA ≥1.0 cm2 and MPG ≥
1 CitationsSource
#1Dimitri ArangalageH-Index: 7
#2Jérémie Abtan (University of Paris)H-Index: 15
Last. Albert FayeH-Index: 38
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Background We report the implementation of a large-scale simulation-based cardiovascular diagnostics course for undergraduate medical students.
3 CitationsSource
Introduction Transoesophageal echocardiography (TEE) under general anesthesia (GA) is the reference technique to guide most of transcatheter cardiac structural interventions (TCI). However, the need for GA represents an important limitation in the context of the dramatic increase of this activity. Multiplane micro TEE probe (MMt) has recently emerged as an alternative imaging technique for procedural guidance that would not require GA. The aim is to evaluate the feasibility of the use of MMt to ...
Up to 30% of patients with aortic stenosis (AS) present with discordant grading (aortic valve area [AVA] <1 cm2, but the mean pressure gradient [MPG] ≥40 mm Hg), raising uncertainty regarding the degree of AS severity [(1)][1]. The aortic root is elliptical and transthoracic echocardiography (
7 CitationsSource
#1Dimitri Arangalage (French Institute of Health and Medical Research)H-Index: 5
#1Dimitri Arangalage (French Institute of Health and Medical Research)H-Index: 7
Last. J. Laschet (French Institute of Health and Medical Research)H-Index: 1
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Background Intraleaflet hematoma has been associated with advanced stages of aortic valve stenosis. Its presence is suspected to be involved in faster disease progression. However, the mechanism whereby the entry and the presence of blood elements into the valves would have an impact on the biology of aortic valvular interstitial cells (VICs) remains to be deciphered. Purpose To evaluate the presence of intraleaflet hematoma, in respect to calcium deposition, at all stages of aortic valve calcif...
Abstract Background Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. Methods In our ongoing prospective cohort (COFRASA/GENERAC), serum Fetuin-A level was measured at baseline and AS severity was evaluated at baseline and yearly thereafter using echocardi...
7 CitationsSource
#1Caroline Kerneis (French Institute of Health and Medical Research)H-Index: 5
#2Nicoletta PasiH-Index: 7
Last. David Messika-Zeitoun (French Institute of Health and Medical Research)H-Index: 16
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Background: Ascending aorta (AA) dilatation is common in aortic valve stenosis (AS) but data regarding AA progression, its determinants and impact of valve anatomy [bicuspid (BAV), or tricuspid (TAV)] are scarce. Methods and Results: Asymptomatic AS patients enrolled in a prospective cohort (COFRASA/GENERAC) with at least 2 years of follow-up were considered in the present analysis. A transthoracic echocardiography (TTE) and a computed tomography (CT) scan were performed at inclusion and yearly ...
7 CitationsSource
#1Ariane TestuzH-Index: 7
#2Virginia Nguyen (French Institute of Health and Medical Research)H-Index: 8
Last. David Messika-Zeitoun (French Institute of Health and Medical Research)H-Index: 16
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Abstract Background Determinants of the progression of aortic stenosis (AS) remained unclear. Metabolic syndrome (MetS) and diabetes are suspected to play an active role but literature is scarce and results conflicting. We sought to assess their impact in an ongoing prospective cohort of asymptomatic patients with at least mild AS. Methods We enrolled 203 patients (73±9years, 75% men) with at least 2years of follow-up. Risk-factors assessment was performed at baseline. Annual progression was cal...
11 CitationsSource