Kenneth A. Miles
University College London
CancerInternal medicineRadiologyPerfusion scanningPathologyMagnetic resonance imagingOncologyPerfusionTomographyMedical physicsPositron emission tomographyLung cancerCarcinomaProstate cancerNuclear medicineIn patientPsma petColorectal cancerComputed tomographyMedicine
Publications 170
#1Balaji Ganeshan (UCL: University College London)H-Index: 32
#2Kenneth A. Miles (UCL: University College London)H-Index: 56
Last. Ashley M. Groves (UCL: University College London)H-Index: 48
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To assess the capability of fractional water content (FWC) texture analysis (TA) to generate biologically relevant information from routine PET/MRI acquisitions for colorectal cancer (CRC) patients. Thirty consecutive primary CRC patients (mean age 63.9, range 42-83 years) prospectively underwent FDG-PET/MRI. FWC tumor parametric images generated from Dixon MR sequences underwent TA using commercially available research software (TexRAD). Data analysis comprised (1) identification of functional ...
#1Jonathan R. Weir-McCall (University of Cambridge)H-Index: 15
#1Weir-McCall (University of Cambridge)
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To compare qualitative and semi-quantitative PET/CT criteria, and the impact of nodule size on the diagnosis of solitary pulmonary nodules in a prospective multicentre trial. Patients with an SPN on CT ≥ 8 and ≤ 30 mm were recruited to the SPUTNIK trial at 16 sites accredited by the UK PET Core Lab. Qualitative assessment used a five-point ordinal PET-grade compared to the mediastinal blood pool, and a combined PET/CT grade using the CT features. Semi-quantitative measures included SUVmax of the...
1 CitationsSource
#1Shih-Hsin Chen (UCL: University College London)H-Index: 1
#2Kenneth A. Miles (UCL: University College London)H-Index: 56
Last. Ashley M. Groves (UCL: University College London)H-Index: 48
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PURPOSE This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer. METHODS This prospective observational study comprised of participants with suspected colorectal cancer categorized as either (a) non-metastatic colon cancer (M0colon), (b) non-metastatic rectal cancer (M0rectum), or (c) metastatic colorectal c...
#1Lauren G. Aoude (UQ: University of Queensland)H-Index: 18
#2Bernadette Z Y Wong (Princess Alexandra Hospital)
Last. Andrew Barbour (UQ: University of Queensland)H-Index: 58
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Treatment for metastatic melanoma includes targeted and/or immuno-therapy. Although many patients respond, only a subset have complete response. As late stage patients often have multiple tumours in difficult access sites, non-invasive techniques are necessary for the development of predictive/prognostic biomarkers. PET/CT scans from 52 stage III/IV melanoma patients were assessed and CT image parameters were evaluated as prognostic biomarkers. Analysis indicated patients with high standard devi...
#1Georges MehawedH-Index: 1
Last. I. Vela
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#1Geon Oh (Princess Alexandra Hospital)H-Index: 1
#2Eoin O’Mahoney (Princess Alexandra Hospital)
Last. Kenneth A. Miles (UCL: University College London)H-Index: 56
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INTRODUCTION: This study aims to evaluate discrepant findings between positron emission tomography/magnetic resonance imaging (PET/MRI) and positron emission tomography/computed tomography (PET/CT) in a cohort of oncological patients and to undertake a phantom study to assess the potential for extended PET acquisitions to lead to false-positive findings on PET/MRI. METHODS: Discrepant findings from a series of 106 patients undergoing same-day (18) F-fluorodeoxyglucose (FDG)-PET/CT and PET/MRI we...
#2Georges MehawedH-Index: 1
Last. Ian VelaH-Index: 14
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#1Jonathan R. Weir-McCall (University of Cambridge)H-Index: 15
#2Stella Joyce (University of Cambridge)H-Index: 1
Last. Fiona J. Gilbert (University of Cambridge)H-Index: 62
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A systematic review and meta-analysis were performed to determine the diagnostic performance of dynamic contrast–enhanced computed tomography (DCE-CT) for the differentiation between malignant and benign pulmonary nodules. Ovid MEDLINE and EMBASE were searched for studies published up to October 2018 on the diagnostic accuracy of DCE-CT for the characterisation of pulmonary nodules. For the index test, studies with a minimum of a pre- and post-contrast computed tomography scan were evaluated. St...
1 CitationsSource
#1Andre Joshi (QUT: Queensland University of Technology)H-Index: 4
#2Matthew J. Roberts (UQ: University of Queensland)H-Index: 20
Last. Ian Vela (QUT: Queensland University of Technology)H-Index: 14
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Prospective evidence for the clinical role and efficacy of prostate specific membrane antigen (PSMA) positron emission tomography (PET)/magnetic resonance imaging (MRI) combining MRI characterization and localization of lesions with PET avidity in comparison to conventional imaging is limited. In a prospective clinical trial, we aimed to evaluate the diagnostic yield and therapeutic impact of PSMA PET/MRI in men with biochemical recurrence (BCR) following curative therapy. A single-centre, prosp...
3 CitationsSource
#1Edward Yeoh (Princess Alexandra Hospital)
#2Kenneth A. Miles (Princess Alexandra Hospital)H-Index: 56
: Patients with colorectal cancer undergo frequent diagnostic imaging to stage the extent of metastatic disease and assess response to treatment. Imaging is typically via diagnostic contrast-enhanced CT or combined FDG-PET/CT. However, recent research has demonstrated promising benefits of combined FDG-PET/MRI in oncologic imaging due to the superior soft-tissue contrast of MRI. The extent of both intrahepatic and extrahepatic disease is important in establishing treatment options for colorectal...