Ka Kit Wong
University of Michigan
CancerInternal medicineRadiologyPET-CTEndocrinologyPathologyMagnetic resonance imagingOncologyPositron emission tomographyBiodistributionNeuroendocrine tumorsDiseaseThyroid cancerScintigraphyMedullary thyroid cancerSingle-photon emission computed tomographyNuclear medicineThyroid carcinomaFdg pet ctThyroidMedicine
109Publications
19H-index
1,377Citations
Publications 97
Newest
1565 null Objectives: null null The synthesis and early preclinical evaluation of [18F]FNP-59, a novel fluorinated analogue of NP-59 and cholesterol, was previously reported.[1] In this work, studies were carried out to determine the biodistribution for human radiation dosimetry estimates of [18F]FNP-59 (Figure 1). NP-59 utility was limited due its high radiation dose; our objective is to demonstrate improved dosimetry and imaging properties with its fluorine-18 analogue, [18F]FNP-59. null Metho...
#2Susan Lawson (UM: University of Michigan)H-Index: 3
Last. Ka Kit WongH-Index: 19
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182 Introduction: Peptide radionuclide receptor therapy (PRRT) for the treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) commenced at our institution in June 2018. The treatment course requires the infusion of Lutathera with concurrent renoprotective amino acid infusion over 4 hours, with a total of 4 cycles given at eight-week intervals. To provide an effective and safe method for the infusion of Lutathera (Lutetium-177 DOTATATE) solution, we identified and tested multiple av...
1370 null Objectives: null null We present our initial experience of a novel PET radiotracer, [18F]fluoro-para-hydroxyphenethylguanidine ([18F]pHPG), a substrate of the norepinephrine transporter (NET) and the vesicular monoamine transporter type 2 (VMAT2), for imaging of patients with metastatic paraganglioma (n=2 to date). [18F]pHPG has been previously reported to localize in presynaptic sympathetic nerve terminals in organs that have high sympathetic innervation (eg. heart, adrenals) in norma...
#1Samuel L. Brady (Cincinnati Children's Hospital Medical Center)H-Index: 3
#2Ka Kit Wong (UM: University of Michigan)H-Index: 19
Last. Barry L. Shulkin (St. Jude Children's Research Hospital)H-Index: 57
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To evaluate the effectiveness of propranolol at mitigating FDG uptake in brown adipose tissue (BAT) of pediatric patients with known or suspected malignancies. PET/CT scans of 3 cohorts of patients treated from 2005 to 2017 were scored for the presence of FDG uptake by BAT at 7 sites: right or left neck/supraclavicular area, right or left axilla, mediastinum, posterior thorax, and abdomen/pelvis. Uptake was scored as follows: 0, none; 1, mild uptake liver. Group 1 consisted of 323 patients (630 ...
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#1Noah Lybik (UM: University of Michigan)H-Index: 1
#2Daniel J. WaleH-Index: 7
Last. Benjamin L. VigliantiH-Index: 22
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ABSTRACT In addition to gastroenteropancreatic neuroendocrine neoplasms, a wide variety of tumors express somatostatin receptors. Somatostatin receptor imaging, heavily utilized in neuroendocrine oncology, may also have utility in the diagnosis of other neoplasms and raises the possibility of potential therapeutic options. We describe the case of a 60-year-old man who underwent 68Ga-DOTATATE PET/CT, demonstrating an avid invasive pituitary macroadenoma. This mass was persistent and refractory de...
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#1Theresa Devasia (UM: University of Michigan)H-Index: 5
#2Yuni K. Dewaraja (UM: University of Michigan)H-Index: 25
Last. Matthew J. Schipper (UM: University of Michigan)H-Index: 34
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Multiple time point SPECT/CT imaging for dosimetry is burdensome for patients and lacks statistical efficiency. A novel method for joint kidney time-activity estimation based on a statistical mixed model, a prior cohort of patients with complete time-activity data, and only one or two imaging points for new patients was compared to previously proposed single time point methods in virtual and clinical patient data. Methods: Data were available for ten patients with neuroendocrine tumors treated w...
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#1Wade P. Winton (UM: University of Michigan)H-Index: 2
#2Benjamin L. Viglianti (UM: University of Michigan)H-Index: 22
Last. Allen F. Brooks (UM: University of Michigan)H-Index: 16
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976 Objectives: We previously reported the synthesis of FNP-59, a novel fluorinated analogue of NP-59 and cholesterol[1]. Cholesterol is normally trafficked to adrenal cortical tissue where it is esterified by ACAT1 for storage and used in the synthesis of hormones. In atherosclerotic disease foam cells also express ACAT1 for esterifying cholesterol to store and prepare it for transport and elimination. A higher yielding concise route to FNP-59 precursor and standard is required to facilitate pr...
#1Susan Lawson (UM: University of Michigan)H-Index: 3
#2Anca M. Avram (UM: University of Michigan)H-Index: 22
Last. Margherita Vicari (UM: University of Michigan)
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3106 Objectives: Functional imaging optimization and standardization are critical to patient individualized treatment and for continuity of care when records are transferred between institutions. Based on radiotheranostic principles we have developed a procedural model for acquisition of high-quality diagnostic radioiodine (131-I)imaging (Dx scan) for guiding therapeutic I-131 administration. This model can be used for developing a Thyroid Cancer Radiotheranostic program at most institutions. Me...
#1James R. Hill (UM: University of Michigan)H-Index: 5
#2Xia Shao (UM: University of Michigan)H-Index: 17
Last. Allen F. Brooks (UM: University of Michigan)H-Index: 16
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PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase 1, ACAT1), is under clinical investigation for numerous adrenal disorders. Ra...
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