Hong Xin
University of California, San Diego
PhosphorylationEndothelial stem cellMitogen-activated protein kinaseUnfolded protein responseVascular endothelial growth factor AKinase insert domain receptorMolecular biologyVEGF receptorsChemistryIn vivoEx vivoMacular degenerationVascular endothelial growth factorGlycosylationHeparinNeovascularizationAngiogenesisRetinalOrgan regenerationAortic ringIntussusceptive angiogenesisVEGF Signaling PathwayHindlimb ischemiaProtein glycosylationNeuropilin 1Computer scienceTyrosine kinaseClinical trialBioinformaticsMetabolismComputational biologyMedicineBiologyCell biology
4Publications
2H-index
228Citations
Publications 4
Newest
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Nilima Biswas (UCSD: University of California, San Diego)H-Index: 16
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 7 authors...
Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have been treated with these drugs worldwide. However, in real-life clinical settings, many patients do not experience the same degree of benefit observed in clinical trials, in part because they receive fewe...
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#1Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
#2Pin Li (UCSD: University of California, San Diego)H-Index: 1
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 10 authors...
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glycan and O-glycan profiles. We further demonstrate that ManN and two N-glycosylation inhibitors stimulate EC proliferation via both JNK activation and th...
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#1Patrycja Nowak-Sliwinska (University of Geneva)H-Index: 32
#2Kari Alitalo (UH: University of Helsinki)H-Index: 194
Last. Arjan W. Griffioen (VU: VU University Amsterdam)H-Index: 83
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The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the eva...
189 CitationsSource
#1Hong Xin (UCSD: University of California, San Diego)H-Index: 2
#2Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 4 authors...
The VEGF-A isoforms play a crucial role in vascular development, and the VEGF signaling pathway is a clinically validated therapeutic target for several pathological conditions. Alternative mRNA splicing leads to the generation of multiple VEGF-A isoforms, including VEGF165. A recent study reported the presence of another isoform, VEGF-Ax, arising from programmed readthrough translation. Compared to VEGF165, VEGF-Ax has a 22-amino-acid extension in the COOH terminus and has been reported to func...
30 CitationsSource