Karl J. Lackner
University of Mainz
Genome-wide association studyInternal medicineEndocrinologyPathologyCardiologyProspective cohort studyCohort studyImmunologyHazard ratioCoronary artery diseaseDepression (differential diagnoses)DiseasePopulationMyocardial infarctionGeneticsAnxietyMedicineCohortBiology
Publications 539
#1Karsten Keller (University Hospital Heidelberg)H-Index: 16
#2Christoph SinningH-Index: 21
Last. Konstantin Strauch (University of Mainz)H-Index: 4
view all 16 authors...
Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th p...
#1Marina Panova-Noeva (University of Mainz)H-Index: 12
#2Bianca Wagner (University of Mainz)H-Index: 2
Last. Philipp S. Wild (University of Mainz)H-Index: 66
view all 16 authors...
BACKGROUND The role of platelets in the pathogenesis of venous thromboembolism (VTE) is receiving increasing attention; however, limited information is available on platelet function in the acute phase of the disease. OBJECTIVE To characterize platelet function according to VTE phenotypes. PATIENTS/METHODS In total, 154 subjects (isolated pulmonary embolism [iPE], n = 28; isolated deep vein thrombosis [iDVT], n = 35; DVT+PE, n = 91) were included. In this study platelet function analyzer (PFA)-2...
#1Achim Fieß (University of Mainz)H-Index: 7
#2Susanne Marx-Groß (University of Mainz)
Last. Alexander K. Schuster (University of Mainz)H-Index: 17
view all 11 authors...
PURPOSE Changes in peripheral corneal thickness are described in various corneal diseases such as corneal ectasia. However, few data exist describing the increase in corneal thickness from central to peripheral and reporting the normal distribution of corneal thickness in rings around the corneal centre. The aim of this study was to report these cornea characteristics and investigate associated factors in a population-based setting. METHODS The Gutenberg Health Study is a prospective, population...
Low birth weight (BW) is associated with altered ocular geometry such as a steeper corneal shape in adulthood. However, it is unclear whether low birth weight affects corneal thickness development in the center or periphery in adulthood which may contribute to ocular disease. The purpose of this study was to investigate corneal thickness in former low birth weight individuals in adulthood. Methods: The German Gutenberg Health Study is a prospective, population-based study in which every particip...
#1Achim Fieß (University of Mainz)H-Index: 7
#2Felix M Wagner (University of Mainz)H-Index: 2
Last. Norbert Pfeiffer (University of Mainz)H-Index: 73
view all 11 authors...
Purpose Low birth weight (BW) is associated with alterations of foveal shape development in childhood-leading to an increased retinal thickness of the fovea. The aim of the present study was to assess whether BW has a long-term effect on foveal retinal thickness (RT) and is still present in adulthood. Methods In the German population-based Gutenberg Health Study (GHS), participants were examined with spectral-domain optical coherence tomography. The association between self-reported BW and RT in...
#1Jürgen H. Prochaska (University of Mainz)H-Index: 14
#2Natalie Arnold (University of Mainz)H-Index: 8
Last. Lisa Eggebrecht (University of Mainz)H-Index: 5
view all 19 authors...
Aims null Evidence regarding the health burden of chronic venous insufficiency (CVI), its clinical determinants, and impact on outcome is scarce. null Methods and results null Systematic phenotyping of CVI according to established CEAP (Clinical-Etiologic-Anatomic-Pathophysiologic) classification was performed in 12 423 participants (age range: 40-80 years) of the Gutenberg Health Study from April 2012 to April 2017. Prevalence was calculated age- and sex-specifically. Multivariable Poisson regr...
#1Jamie NourseH-Index: 3
#2Sergey TokalovH-Index: 3
Last. Sven DanckwardtH-Index: 10
view all 13 authors...
The topology of gene expression and protein localization is a crucial characteristic of life, where the spatiotemporal dynamic of secretory proteins instruct higher order organization, including the orchestration of developmental and adaptive programs. However, tools to non-invasively interrogate the fate of secretory proteins in vivo are scarce. Here we introduce a genetic tagging strategy for in vivo imaging of the secretion and expression dynamics of secretory proteins in living animals. Appl...
#1Volker Schmitt (University of Mainz)H-Index: 14
Last. Manfred E. Beutel (University of Mainz)H-Index: 54
view all 15 authors...
Use of galectin-3 for assessing cardiac function in prediabetes and type 2 diabetes mellitus (T2DM) needs to be established. Within the Gutenberg Health Study cohort (N = 15,010, 35-74 years) patient characteristics were investigated regarding galectin-3 levels. Prognostic value of galectin-3 compared to NT-proBNP concerning cardiac function and mortality was assessed in individuals with euglycaemia, prediabetes and T2DM in 5 years follow-up. Higher galectin-3 levels related to older age, female...
PURPOSE: We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. METHODS: The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus....
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