Robert F. Storey
University of Sheffield
Internal medicineSurgeryCardiologyHazard ratioPrasugrelAspirinAcute coronary syndromeClopidogrelCoronary artery diseasePercutaneous coronary interventionTicagrelorPlatelet aggregation inhibitorIn patientConventional PCIP2Y12Myocardial infarctionStrokeMedicinePlateletPharmacology
484Publications
90H-index
38.9kCitations
Publications 482
Newest
#1Nicholas C. Sanderson (University of Sheffield)
#2William A E Parker (University of Sheffield)H-Index: 8
Last. Robert F. Storey (University of Sheffield)H-Index: 90
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Platelets participate centrally in atherothrombosis, resulting in vessel occlusion and ischaemia. Consequently, optimisation of antiplatelet regimens has the potential to further reduce the residual burden of morbidity and mortality associated with atherosclerosis. Ticagrelor is a potent oral platelet P2Y12 receptor antagonist that (1) inhibits a central amplification pathway of platelet activation directly as well as via an active metabolite, (2) has a rapid onset and offset of antiplatelet act...
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#1Jean-Philippe Collet (CUA: The Catholic University of America)H-Index: 1
#2Holger ThieleH-Index: 97
Last. Thor EdvardsenH-Index: 81
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#1Thomas A Nelson (University of Sheffield)
#2William A E Parker (University of Sheffield)H-Index: 8
Last. Robert F. Storey (University of Sheffield)H-Index: 90
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Inflammation plays a key role in cardiovascular disease by contributing to atherothrombosis. The PLATelet inhibition and patient Outcomes (PLATO) study (NCT00391872) compared ticagrelor to clopidogrel in patients with acute coronary syndromes and demonstrated fewer cardiovascular events with ticagrelor but lower white blood cell counts (WBC) with clopidogrel. In this further analysis of the PLATO biomarker substudy, we assessed associations between WBC and clinical characteristics, biomarker lev...
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#1William A E Parker (University of Sheffield)H-Index: 8
#2Robert F. Storey (University of Sheffield)H-Index: 90
### Learning objectives Globally, much morbidity and premature mortality arises from coronary artery disease (CAD). Coronary artery atherothrombosis is the dominant cause of acute coronary syndromes (ACS), including spontaneous myocardial infarction (MI) and unstable angina. Those with chronic coronary syndromes (CCS), including stable CAD or an ACS event >1 year ago, are at ongoing atherothrombotic risk.1 Modifiable or partially modifiable risk factors such as hypercholesterolaemia, diabetes me...
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#1Joel A. Morales-Rosado (Mayo Clinic)H-Index: 4
#2Kashish Goel (Vandy: Vanderbilt University)H-Index: 5
Last. Naveen L. Pereira (Mayo Clinic)H-Index: 36
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Purpose Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annotation and functional studies. Methods Seventy ST cases on clopidogrel identified from the PLATO trial (n = 58) and Mayo Clinic biorepository (n = 12) were matched 1:1 with controls for age, race, sex, ...
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#1Paul A. GurbelH-Index: 86
#2Udaya S. TantryH-Index: 70
Last. Robert F. Storey (University of Sheffield)H-Index: 90
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#1Marco ZimarinoH-Index: 30
Last. Goran StankovicH-Index: 51
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Coronary bifurcations exhibit localised turbulent flow and an enhanced propensity for atherothrombosis, platelet deposition and plaque rupture. Percutaneous coronary intervention (PCI) of bifurcation lesions is associated with an increased risk of thrombotic events. Such risk is modulated by anatomical complexity, intraprocedural factors and pharmacological therapy. There is no consensus on the appropriate PCI strategy or the optimal regimen and duration of antithrombotic treatment in order to d...
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#2Walter S. Speidl (Medical University of Vienna)H-Index: 31
Last. Kristian Thygesen (Aarhus University Hospital)H-Index: 57
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The formation of a thrombus in an epicardial artery may result in an acute myocardial infarction (AMI). Despite major advances in acute treatment using network approaches to allocate patients to timely reperfusion and optimal antithrombotic treatment, patients remain at high risk for thrombotic complications. Ongoing activation of the coagulation system as well as thrombin-mediated platelet activation may both play a crucial role in this context. Whether measurement of circulating biomarkers of ...
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#1Samer Al Said (University Hospital Heidelberg)H-Index: 4
#2Samer Alabed (University of Sheffield)H-Index: 11
Last. Hugo A. Katus (Heidelberg University)H-Index: 122
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