Wenliang Li
University of Texas Health Science Center at Houston
CancerInternal medicineKinaseSmall hairpin RNAImmunologyWilms' tumorProstateMetastasisTumor progressionProstate cancerNeuroendocrine differentiationAngiogenesisCD44Cancer researchSignal transductionMedicineEpithelial–mesenchymal transitionCell cultureBiologyCell biologyCancer cell
37Publications
16H-index
1,037Citations
Publications 31
Newest
#1Zheng Wang (University of Texas Health Science Center at Houston)H-Index: 1
#2Yicheng Zhao (University of Texas Health Science Center at Houston)H-Index: 1
Last. Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
view all 4 authors...
Androgen deprivation therapy (ADT), a major treatment for prostate cancer, is initially effective for the majority of patients. However, prolonged ADT promotes drug resistance and progression to an aggressive variant with reduced androgen receptor signaling, so called neuroendocrine prostate cancer (NEPC). NEPC is lethal, poorly understood, and without effective treatment. Elevated expression of neuroendocrine markers and increased angiogenesis are two prominent phenotypes of NEPC. Several studi...
2 CitationsSource
#1Yan ZhangH-Index: 12
#2Da-Yong Zheng (University of Texas Health Science Center at Houston)H-Index: 18
Last. Wenliang LiH-Index: 16
view all 8 authors...
1 CitationsSource
#1Yicheng Zhao (University of Texas Health Science Center at Houston)H-Index: 1
#2Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
Prostate cancer is a complex, heterogeneous disease that mainly affects the older male population with a high-mortality rate. The mechanisms underlying prostate cancer progression are still incompletely understood. Beta-adrenergic signaling has been shown to regulate multiple cellular processes as a mediator of chronic stress. Recently, beta-adrenergic signaling has been reported to affect the development of aggressive prostate cancer by regulating neuroendocrine differentiation, angiogenesis, a...
10 CitationsSource
#1Yan Zhang (HUST: Huazhong University of Science and Technology)H-Index: 12
#2Da-Yong Zheng (University of Texas Health Science Center at Houston)H-Index: 18
Last. Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
view all 16 authors...
The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its neuroendocrine differentiation (NED) and angiogenic phenotypes. Here we reveal that NED and angiogenesis are molecularly connected through EZH2 (enhancer of zeste homolog 2). NED and angiogenesis are both regulated by ADT-activated CREB (cAMP response element-binding protein) that in turn enhances EZH2 activity. We also uncover a...
58 CitationsSource
#1Linna Li (University of Texas Health Science Center at Houston)H-Index: 3
#2Ning Su (University of Texas Health Science Center at Houston)H-Index: 5
Last. Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
view all 8 authors...
ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple epithelial cell lines, while having different impacts on cell growth in different cell lines. Conversely, depletion of ZAK in aggressive mesenchymal cancer cells reversed EMT phenot...
7 CitationsSource
#1Da-Yong Zheng (University of Texas Health Science Center at Houston)H-Index: 18
#2Mohit Hulsurkar (University of Texas Health Science Center at Houston)H-Index: 4
Last. Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
view all 8 authors...
Treatment-related neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer that is believed to arise through neuroendocrine differentiation (NED) from prostate adenocarcinoma (PAC) upon castration resistance to androgen deprivation treatment (ADT). t-NEPC is highly metastatic with poor prognosis. With the recent introduction of potent ADT drugs in clinic, the incidence of t-NEPC is expected to increase dramatically. No effective therapeutic is available for t-NEPC and ...
Source
#1Mohit Hulsurkar (University of Texas Health Science Center at Houston)H-Index: 4
#2Z. Li (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Wenliang Li (University of Texas at Austin)H-Index: 16
view all 6 authors...
Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1
36 CitationsSource
#1Hubert TsengH-Index: 15
#2Jacob A. GageH-Index: 7
Last. Glauco R. SouzaH-Index: 20
view all 10 authors...
Precision medicine holds the promise of designing patient-specific therapies to improve therapeutic efficiency. However, the scarcity of tumor and biopsy tissue is a limiting factor in the development of diagnostic assays. Cells isolated from these tissues could be used to overcome these issues, while serving as the basis for assays to diagnose and guide treatment. It is critical that the in vitro culture of these cells be performed in three-dimensional (3D) environments that can better replicat...
Source
#1Meixiang Sang (University of Texas Health Science Center at Houston)H-Index: 1
#2Mohit Hulsurkar (University of Texas Health Science Center at Houston)H-Index: 4
Last. Wenliang LiH-Index: 16
view all 11 authors...
// Meixiang Sang 1, 7, * , Mohit Hulsurkar 1, 5, * , Xiaochong Zhang 1, 7, * , Haiping Song 1, 8 , Dayong Zheng 1, 9 , Yan Zhang 1, 10 , Min Li 2 , Jianming Xu 3 , Songlin Zhang 2 , Michael Ittmann 4 , Wenliang Li 1, 5, 6 1 Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA 2 Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA 3 D...
29 CitationsSource
#1Linna Li (University of Texas Health Science Center at Houston)
#2Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
Last. Wenliang Li (University of Texas Health Science Center at Houston)H-Index: 16
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The epithelial-mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of aggressive traits by epithelial cancer cells. To identify novel regulators of EMT, we carried out cDNA screens that covered 500 human kinases. Subsequent characterization of candidate kinases led us to uncover cyclin-dependent kinase-like 2 (CDKL2) as a novel potent promoter for EMT and breast cancer progression. CDKL2-expressing human mammary gla...
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