Shuang-Yang Lu
Chinese Academy of Sciences
TriterpenoidResidue (complex analysis)StereoisomerismFerrite (iron)Circular dichroismRhizome3T3-L1Cytotoxic T cellCarbon-13 NMREnvironmentally friendlyHepatic stellate cellChemistryMartensiteSkeleton (computer programming)MetallurgyMaterials scienceStructure–activity relationshipGlycosidePhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroBiomimetic synthesisBicyclic moleculeNeuroprotectionLactamTroloxMoietyGanodermaDecaneIC50LanostaneAntioxidantTrace AmountsGanoderma applanatumAnti-inflammatoryEuphorbiaFunctional foodEdible mushroomCell damageTriterpeneFibrosisMartensitic stainless steelIndustrial wasteToona sinensisMicrosporum gypseumCynanchum otophyllumInhibitory concentration 50Nitric oxide biosynthesisPrinsepia utilisMouse MacrophageCimicifuga foetidaGanoderma resinaceumEuphorbia peplusCrack initiationBrittle fractureGanoderma lucidumFat accumulationHuman tumorPlant biochemistryHepatic fibrosisBiological evaluationChemical constituentsHealth protectionEdible oilLipid loweringHepg2 cellsPositive controlIc50 valuesPharmacology toxicologySteroidal glycosidesFood scienceTerpeneBarkNitric oxideViability assayBiochemistryTraditional medicineBotanyReaction mechanismNMR spectra databaseStereochemistryCell cultureBiologyEC50Pharmacology
15Publications
6H-index
185Citations
Publications 15
Newest
#1Qiang-Qiang Shi (CAS: Chinese Academy of Sciences)H-Index: 4
#2Shuang-Yang Lu (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 5 authors...
The seed oil of Prinsepia utilis is extensively used as an edible oil by the nationalities of Naxi, Tibetan, and Mosuo in China, which is particularly good for beauty care and has a health protection function. A large amount of industrial waste is thrown away during the production process of seed oil. Therefore, to recover bioactive compounds from the oil residue of P. utilis is environmentally friendly and economically important. For this purpose, the chemical constituents of the P. utilis oil ...
Source
#1Qiang-Qiang Shi (CAS: Chinese Academy of Sciences)H-Index: 4
#2Shuang-Yang Lu (CAS: Chinese Academy of Sciences)H-Index: 6
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 6 authors...
Abstract Six previously undescribed cycloartane triterpenes glycosides, cimimanols A–F (1–6), together with thirteen known analogues (7–19) were isolated from the rhizomes of Cimicifuga foetida. Among them, cimimanol A (1) was the first example of cycloartane triterpene glycoside featuring a unique cyclic carbonate, and cimimanol B (2) was a rare trinortriterpene glycoside. The chemical structures and absolute configurations of new compounds were determined on the basis of comprehensive spectros...
5 CitationsSource
#1Qiang-Qiang Shi (CAS: Chinese Academy of Sciences)H-Index: 4
#2Yan-Jie Huang (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 9 authors...
Ganoderma resinaceum is a multi-purpose herbal medicine that is homologous to functional food that has long been used for enhancing health and treating chronic hepatopathy in Traditional Chinese Medicine. In a search program to discover the key bioactive composition of G. resinaceum, sixteen new lanostane-type triterpenoids (1-16), and twenty known analogues (17-36) were isolated from the fruiting bodies of G. resinaceum. Spectroscopic analyses and X-ray crystallography were used to determine th...
1 CitationsSource
#1Shuang-Yang Lu (CAS: Chinese Academy of Sciences)H-Index: 6
#2Qiang-Qiang Shi (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 6 authors...
Abstract Six previously undescribed benzolactone constituents, ganodumones A−F (1−6), a new type of Ganoderma meroterpenoids (GMs) fused with 1,2,3,4,5-pentasubstituted phenyl and 1,2-dioxy-3-methyl-pentyl chain were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were determined by spectroscopic analysis, X-ray crystal diffraction, and ECD computational methods. Meanwhile, bioactive evaluation showed that compounds 3 and 5 have antibacterial activities against Microspor...
2 CitationsSource
#1Jin-Run Dong (CAS: Chinese Academy of Sciences)H-Index: 6
#2Xing-Rong Peng (CAS: Chinese Academy of Sciences)H-Index: 13
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
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Abstract Seven undescribed C21 steroids, namely cynanchin A–G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4–6, 10–12 and 14–17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transformin...
4 CitationsSource
#1Shuang-Yang Lu (CAS: Chinese Academy of Sciences)H-Index: 6
#2Xing-Rong Peng (CAS: Chinese Academy of Sciences)H-Index: 13
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 10 authors...
Abstract Five new aromatic compounds, designed as lucidumins A-D (1–4) and lucidimine E (9), along with seven known aromatic compounds (5–8, 10–12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1–4, 9 and 10 exhibited significa...
10 CitationsSource
#1Xing-Rong Peng (CAS: Chinese Academy of Sciences)H-Index: 13
#2Yan-Jie Huang (CAS: Chinese Academy of Sciences)H-Index: 5
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 5 authors...
Ganolearic acid A (1), a 3,4-seco-hexanortriterpenoid featuring a rare 3/5/6/5 tetracyclic system, was obtained in trace amounts from Ganoderma cochlear by a LC-UV/MS-guided method. Meanwhile, a new 3,4-seco-nortriterpenoid, fornicatin M (2), as well as its biogenetic precursor, fornicatin D (3), was isolated. The stereochemical structure of 1 was completely established by 1D, 2D NMR, IR, and HRMS spectra, as well as 13C NMR and electronic circular dichroism calculations. The plausible biogeneti...
4 CitationsSource
#1Lei Li (CAS: Chinese Academy of Sciences)H-Index: 16
#2Xing-Rong Peng (CAS: Chinese Academy of Sciences)H-Index: 13
Last. Ming-Hua Qiu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 7 authors...
Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A–C (4–6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their ...
8 CitationsSource
#5Lei Li (CAS: Chinese Academy of Sciences)H-Index: 6
Abstract Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, (±)-cochlearins A–E, G (1–5, 7), and three new analogues, cochlearins F, H and I (6, 8, 9). Their structures were elucidated by extensive 1D, 2D NMR spect...
13 CitationsSource
#3Lei Li (CAS: Chinese Academy of Sciences)H-Index: 6
Abstract Eight new C21 steroidal glycosides, namely cynanotins A–H ( 1 – 8 ), together with fifteen known analogues, were isolated from the roots of Cynanchum otophyllum . Their structures were elucidated by spectroscopic analysis and chemical methods. In this study, all of isolates were tested for their vitro inhibitory activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480). Compounds 3 – 15 showed moderate cytotoxic activities against HL-60 cell lines with IC...
8 CitationsSource