Aijun Liu
Guangzhou University of Chinese Medicine
PhosphorylationDownregulation and upregulationHDAC3Wnt signaling pathwayCaspase 1microRNAEmbryonic stem cellCellular differentiationDNA demethylationPyroptosisFetusChemistryEmbryoSmall interfering RNASubcellular localizationInflammationArthritisWedelolactoneInflammasomeInvolucrinSmall intestinePaeonol5-HydroxymethylcytosinePaeonia suffruticosaHMGB1OncogeneExtracellularCateninOrganogenesisBone morphogenetic proteinSecretionTransfectionSignal transductionKeratinBiologyEmbryogenesisEpidermis (botany)Cell biology
5Publications
3H-index
21Citations
Publications 5
Newest
#1Ziwei Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jianping Dou (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 9 authors...
MicroRNAs (miRNAs) participate in the repair of skin trauma. Our previous study indicated that loureirin A promoted hair follicle stem cells (HFSCs) to repair skin epidermis. However, the mechanism of miRNA-mediated regulation of loureirin A-induced HFSC differentiation remained to be explored. In the present study, HFSCs from rat vibrissa were identified by immunofluorescence in vitro. Microarray and quantitative real time polymerase chain reaction (qRT-PCR) analyses demonstrated that miR-203a-...
1 CitationsSource
#1Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 2
#2Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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OBJECTIVES Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti-inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages and its influence on MSU-induced inflammation. MATERIALS AND METHODS BMDM, J774A.1 and PMA-differentiated THP-1 macrophages were primed with LPS and then stimulated with ATP or nigericin or MSU crystal ...
9 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Fangfang Xie (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
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: Genomic DNA demethylation is important for mammalian embryonic development and organ function. 5-Hydroxymethylcytosine (5hmC) is considered a novel epigenetic marker. Ten-eleven translocation (TET) enzymes convert 5-methylcytosine (5mC) to 5hmC. To explore the dynamic changes of epigenetic modifications during organogenesis in the late mouse fetus, the regional distribution and histological localization of 5hmC and TET enzymes was investigated by immunohistochemical method. The liver of mouse ...
1 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yuqiong Wu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
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: Our previous study indicated that loureirin A induces hair follicle stem cell (HFSC) differentiation through Wnt/β‑catenin signaling pathway activation. However, if and how microRNAs (miRNAs/miRs) modulate loureirin A‑induced differentiation remains to be elucidated. In the present study, HFSCs were separated from the vibrissae of rats and identified by CD34 and keratin, type 1 cytoskeletal (K)15 expression. Microarray‑based miRNA profiling analysis revealed that miR‑339‑5p was downregulated i...
9 CitationsSource
#1Qin Xu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Xia Liu (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
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Extracellular high mobility group box 1 (HMGB1) is a lethal pro-inflammatory mediator in endotoxin shock. Hyperacetylation of HMGB1, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), changes its subcellular localization and secretion to the extracellular matrix. Paeonol (2′-hydroxy-4′-methoxyacetophenone), one of the main active components of Paeonia suffruticosa, exerts anti-inflammatory effects. Our previous study demonstrated that Paeonol inhibited the relocatio...
6 CitationsSource