Aaron F. Struck
University of Wisconsin-Madison
Internal medicineRadiologySurgeryNeuropsychologyMagnetic resonance imagingPsychologyNeuroscienceCognitionIctalPositron emission tomographyEpilepsyEpilepsy surgeryTemporal lobeNuclear medicineConnectomeElectroencephalographyAudiologyReceiver operating characteristicNeuroimagingClinical psychologyMedicine
57Publications
14H-index
643Citations
Publications 59
Newest
#1Elsa Juan (UvA: University of Amsterdam)H-Index: 10
#2Urszula Górska (Jagiellonian University)H-Index: 7
Last. Mélanie Boly (UW: University of Wisconsin-Madison)H-Index: 79
view all 15 authors...
Abstract null Loss of consciousness (LOC) is a hallmark of many epileptic seizures and carries risks of serious injury and sudden death. While cortical sleep-like activities accompany LOC during focal impaired awareness (FIA) seizures, the mechanisms of LOC during focal to bilateral tonic-clonic (FBTC) seizures remain unclear. Quantifying differences in markers of cortical activation and ictal recruitment between FIA and FBTC seizures may also help to understand their different consequences for ...
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#1Bruce P. Hermann (UW: University of Wisconsin-Madison)H-Index: 106
#2Aaron F. Struck (VA: United States Department of Veterans Affairs)H-Index: 14
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 39
view all 6 authors...
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies and impose a substantial human and economic burden. Over the past century, the classic approach to understanding the aetiology and course of these comorbidities has been through the prism of the medical taxonomy of epilepsy, including its causes, course, characteristics and syndromes. Although this ‘lesion model’ has long served as the organizing paradigm for the field, substantial challenges to this model ha...
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#1Jiang-Ling Song (Northwest University (China))H-Index: 5
#2Jennifer A. Kim (Yale University)H-Index: 13
Last. M. Brandon Westover (Harvard University)H-Index: 39
view all 5 authors...
Secondary brain injury (SBI) is defined as new or worsening injury to the brain after an initial neurologic insult, such as hemorrhage, trauma, ischemic stroke, or infection. It is a common and potentially preventable complication following many types of primary brain injury (PBI). However, mechanistic details about how PBI leads to additional brain injury and evolves into SBI are poorly characterized. In this work, we propose a mechanistic model for the metabolic supply demand mismatch hypothes...
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#1Bruce P. Hermann (UW: University of Wisconsin-Madison)H-Index: 106
#2Aaron F. Struck (UW: University of Wisconsin-Madison)H-Index: 14
Last. Jana E. Jones (UW: University of Wisconsin-Madison)H-Index: 36
view all 5 authors...
OBJECTIVE To identity phenotypes of self-reported symptoms of psychopathology and their correlates in patients with temporal lobe epilepsy (TLE). METHOD 96 patients with TLE and 82 controls were administered the Symptom Checklist 90-Revised (SCL-90-R) to characterize emotional-behavioral status. The nine symptom scales of the SCL-90-R were analyzed by unsupervised machine learning techniques to identify latent TLE groups. Identified clusters were contrasted to controls to characterize their asso...
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#1Camille Garcia-Ramos (UW: University of Wisconsin-Madison)H-Index: 10
#2Aaron F. Struck (UW: University of Wisconsin-Madison)H-Index: 14
Last. Bruce P. Hermann (UW: University of Wisconsin-Madison)H-Index: 106
view all 10 authors...
Abstract Purpose The neuropsychological complications of temporal lobe epilepsy are characterized by a spectrum of reproducible cognitive phenotypes that vary in the presence, type and degree of impairment. The nature of the disruptions to the neuropsychological networks that underlie these phenotypes remain to be characterized and represent the subject of this investigation. Methods Participants included 30 healthy controls and 104 patients with temporal lobe epilepsy who fell into three cognit...
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#1Aaron F. Struck (UW: University of Wisconsin-Madison)H-Index: 14
#2Mélanie Boly (UW: University of Wisconsin-Madison)H-Index: 79
Last. Bruce P. Hermann (UW: University of Wisconsin-Madison)H-Index: 106
view all 13 authors...
Abstract Temporal lobe epilepsy (TLE) has been conceptualized as focal disease with a discrete neurobiological focus and can respond well to targeted resection or ablation. In contrast, the neuro-cognitive deficits resulting from TLE can be widespread involving regions beyond the primary epileptic network. We hypothesize that this seemingly paradoxical findings can be explained by differences in connectivity between the primary epileptic region which is hyper-connected and its secondary influenc...
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#1Wendong Ge (Harvard University)H-Index: 6
#2Jin Jing (Harvard University)H-Index: 7
Last. Hiba A. Haider (Emory University)H-Index: 8
view all 30 authors...
OBJECTIVES Seizures and seizure-like electroencephalography (EEG) patterns, collectively referred to as "ictal interictal injury continuum" (IIIC) patterns, are commonly encountered in critically ill patients. Automated detection is important for patient care and to enable research. However, training accurate detectors requires a large labeled dataset. Active Learning (AL) may help select informative examples to label, but the optimal AL approach remains unclear. METHODS We assembled >200,000 h ...
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#1Eric W. Moffet (NU: Northwestern University)H-Index: 2
#2Ruben Verhagen (UW: University of Wisconsin-Madison)H-Index: 1
Last. Mélanie Boly (UW: University of Wisconsin-Madison)H-Index: 79
view all 12 authors...
Background: Slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep reflects synaptic potentiation during preceding wakefulness. Epileptic activity may induce increases in state-dependent SWA in human brains, therefore, localization of SWA may prove useful in the presurgical workup of epileptic patients. We analyzed high-density electroencephalography (HDEEG) data across vigilance states from a reflex epilepsy patient with a clearly localizable ictal symptomatogenic zone to provide a...
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#1Charlene N. Rivera Bonet (UW: University of Wisconsin-Madison)H-Index: 3
#2Gyujoon Hwang (UW: University of Wisconsin-Madison)H-Index: 6
Last. Mary E. Meyerand (UW: University of Wisconsin-Madison)H-Index: 23
view all 23 authors...
Neuroticism, a core personality trait characterized by a tendency towards experiencing negative affect, has been reported to be higher in people with temporal lobe epilepsy (TLE) compared with healthy individuals. Neuroticism is a known predictor of depression and anxiety, which also occur more frequently in people with TLE. The purpose of this study was to identify abnormalities in whole-brain resting-state functional connectivity in relation to neuroticism in people with TLE and to determine t...
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#1Shobhit Singla (Yale University)H-Index: 2
#2Gabriella E Garcia (Yale University)H-Index: 1
Last. Jennifer A. Kim (Yale University)H-Index: 13
view all 12 authors...
PURPOSE OF REVIEW Acute brain injury (ABI) is a broad category of pathologies, including traumatic brain injury, and is commonly complicated by seizures. Electroencephalogram (EEG) studies are used to detect seizures or other epileptiform patterns. This review seeks to clarify EEG findings relevant to ABI, explore practical barriers limiting EEG implementation, discuss strategies to leverage EEG monitoring in various clinical settings, and suggest an approach to utilize EEG for triage. RECENT FI...
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