Qingzhong Xiao
Guangzhou Medical University
Endothelial stem cellInternal medicinePathologyEmbryonic stem cellCellular differentiationCellGene expressionMolecular biologyGene knockdownChemistryProgenitor cellImmunologyNeointimaVascular smooth muscleStem cellSmooth muscle cell differentiationCancer researchMedicineBiologyCell biology
Publications 150
#1Mei Yang (SJTU: Shanghai Jiao Tong University)H-Index: 9
#2Qishan Chen (QMUL: Queen Mary University of London)H-Index: 15
Last. Li Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 2
view all 12 authors...
BACKGROUND AND PURPOSE Neointimal hyperplasia (NIH) is the fundamental cause for vascular diseases, and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase (NE) has been suggested as potential therapeutic for multiple diseases. Here we investigated the role of NE in VSMC functions and injury-induced NIH, and further explored the therapeutic potential of targeting NE in NIH. EXPERIMENTAL APPROACH VSMCs were used to analyze the effects of NE on V...
#1Chengxin Zhang (Anhui Medical University)
#2Kaiyuan Niu (QMUL: Queen Mary University of London)
Last. Zhaolin Chen (USTC: University of Science and Technology of China)
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Increasing evidence has suggested that noncoding RNAs (ncRNAs) have vital roles in cardiovascular tissue homeostasis and diseases. As a main subgroup of ncRNAs, long ncRNAs (lncRNAs) have been reported to play important roles in lipid metabolism, inflammation, vascular injury, and angiogenesis. They have also been implicated in many human diseases including atherosclerosis, arterial remodeling, hypertension, myocardial injury, cardiac remodeling, and heart failure. Importantly, it was reported t...
#1Longlong Hu (NCU: Nanchang University)H-Index: 1
#2Kai Zou (NCU: Nanchang University)
Last. Renqiang Yang (NCU: Nanchang University)H-Index: 4
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Platelet mitophagy is a major pathway involved in the clearance of injured mitochondria during hemostasis and thrombosis. Prohibitin 2 (PHB2) has recently emerged as an inner mitochondrial membrane receptor involved in mitophagy. However, the mechanisms underlying PHB2‑mediated platelet mitophagy and activation are not completely understood. PHB2 is a highly conserved inner mitochondrial membrane protein that regulates mitochondrial assembly and function due to its unique localization on the mit...
1 CitationsSource
#1Weiwei An (QMUL: Queen Mary University of London)H-Index: 7
#2Le A. Luong (QMUL: Queen Mary University of London)H-Index: 5
Last. Qingzhong Xiao (Guangzhou Medical University)
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AIM Pathological arterial remodelling including neointimal hyperplasia and atherosclerosis is the main underlying cause for occluding arterial diseases. Cezanne is a novel deubiquitinating enzyme, functioning as a NF-кB negative regulator, and plays a key role in renal inflammatory response and kidney injury induced by ischemia. Here we attempted to examine its pathological role in vascular smooth muscle cell (VSMC) pathology and arterial remodelling. METHODS AND RESULTS Cezanne expression level...
#1Dan Chen (CQMU: Chongqing Medical University)H-Index: 6
#2Cheng Zhang (CQMU: Chongqing Medical University)H-Index: 10
Last. Qingzhong Xiao (Guangzhou Medical University)H-Index: 42
view all 13 authors...
Increasing evidence has suggested a critical role for endothelial-to-mesenchymal transition (EndoMT) in a variety of pathological conditions. MicroRNA-200c-3p (miR-200c-3p) has been implicated in epithelial-to-mesenchymal transition. However, the functional role of miR-200c-3p in EndoMT and neointimal hyperplasia in artery bypass grafts remains largely unknown. Here we demonstrated a critical role for miR-200c-3p in EndoMT. Proteomics and luciferase activity assays revealed that fermitin family ...
2 CitationsSource
#1Eithne Margaret Maguire (QMUL: Queen Mary University of London)H-Index: 8
#2Qingzhong Xiao (Guangzhou Medical University)H-Index: 42
Neointimal hyperplasia (NIH) is a pathological process occurring in the blood vessel wall during atherosclerosis and in-stent restenosis (ISR). Due to the abundance of vascular smooth muscle cells (VSMCs) within neointimal lesions, VSMCs have long been considered as a key cellular target in preventing NIH. Non-coding RNA molecules such as micro-RNA (miRNAs), long non-coding RNA (lncRNAs) and circular RNAs (circRNAs) expressed in VSMCs offer unique therapeutic targets for tackling VSMC phenotype ...
9 CitationsSource
#1Shiping He (QMUL: Queen Mary University of London)H-Index: 3
#2Feng Yang (ZJU: Zhejiang University)H-Index: 9
Last. Qingzhong Xiao (Guangzhou Medical University)H-Index: 42
view all 11 authors...
Inflammatory smooth muscle cells (iSMCs) generated from adventitial stem/progenitor cells (AdSPCs) have been recognised as a new player in cardiovascular disease, and microRNA-214-3p (miR-214-3p) has been implicated in mature vascular SMC functions and neointimal hyperplasia. Here, we attempted to elucidate the functional involvements of miR-214-3p in iSMC differentiation from AdSPCs and unravel the therapeutic potential of miR-214-3p signalling in AdSPCs for injury-induced neointimal hyperplasi...
3 CitationsSource
#1Chenxin Liu (QMUL: Queen Mary University of London)H-Index: 1
#2Kaiyuan Niu (QMUL: Queen Mary University of London)H-Index: 1
Last. Qingzhong Xiao (Guangzhou Medical University)H-Index: 42
view all 3 authors...
Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect the haemostasis and physiological functions of all the vital tissues/organs and is one of the main underlying causes for a variety of human diseases including cardiovascular diseases. Current pharmacological interventions aiming to either delay or stop progression of vasculopathies are suboptimal, thus searching novel, targeted, risk-reducing therapeutic agents, or vascular grafts with full regenerative...
2 CitationsSource
#1Xiaoye Zheng (ZJU: Zhejiang University)H-Index: 5
#2Yutao Wu (ZJU: Zhejiang University)H-Index: 10
Last. Li Zhang (ZJU: Zhejiang University)H-Index: 25
view all 10 authors...
#1Xiangyuan Pu (ZJU: Zhejiang University)H-Index: 7
#2Kenneth H. Chan (QMUL: Queen Mary University of London)H-Index: 14
Last. Shu Ye (STU: Shantou University)H-Index: 63
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Abstract Background and aims Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis. Methods and results ADAMTS7 knockdown in vascular endothelial cells (ECs) attenuated their angiogenesis potential, whereas augmented ADAMTS7...
1 CitationsSource