Héctor Quezada
Katholieke Universiteit Leuven
GeneProteomeDrug resistanceIsozymeFlux (metabolism)Allosteric regulationEnzymeChemistryGlycolysisLysineSaccharomyces cerevisiaeYeastMitochondrionGeneticsBiosynthesisBiochemistryOxidative phosphorylationMedicineBiologyMicrobiologyCell biology
36Publications
13H-index
615Citations
Publications 35
Newest
#1Orlando Salinas-Jaramillo (IPN: Instituto Politécnico Nacional)
#2Alejandra Monroy-Arreola (IPN: Instituto Politécnico Nacional)H-Index: 1
Last. Pedro Cortes-Reynosa (CINVESTAV)H-Index: 11
view all 13 authors...
Cutaneous drug-induced reactions are immune-mediated responses that can lead to life-threatening diseases such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, and toxic epidermal necrolysis, collectively known as severe cutaneous adverse reactions (SCARs). Unfortunately, they cannot be predicted during drug development, and, at present, a prognostic biomarker is not available nor are validated in vitro assays for diagnosis. Thus, by using proteomic and...
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Cytochrome c (cyt-c) release from the mitochondria to the cytosol is a key process in the initiation of hepatocyte apoptosis involved in the progression of non-alcoholic fatty liver disease (NAFLD) to fibrosis, cirrhosis and hepatocellular carcinoma. Hepatocyte apoptosis may be related to lipotoxicity due to the accumulation of palmitic acid and palmitoyl-CoA (Pal-CoA). Therefore, the aim of this study is to examine whether Pal-CoA induces cyt-c release from liver mitochondria of sucrose-fed rat...
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view all 10 authors...
The genome of the SARS-CoV-2 virus, the causal agent of the COVID-19 pandemic, has diverged due to multiple mutations since its emergence as a human pathogen in December 2019. Some mutations have defined several SARS-CoV-2 clades that seem to behave differently in terms of regional distribution and other biological features. Next-generation sequencing (NGS) approaches are used to classify the sequence variants in viruses from individual human patients. However, the cost and relative scarcity of ...
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#1Keiko Taniguchi-Ponciano (Mexican Social Security Institute)H-Index: 6
#2Eduardo Peña-Martínez (Mexican Social Security Institute)H-Index: 5
Last. Moisés Mercado (Mexican Social Security Institute)H-Index: 27
view all 20 authors...
Background: Pituitary adenomas (PA) are the second most common tumor in the central nervous system and have low counts of mutated genes. Splicing occurs in 95% of the coding RNA. There is scarce information about the spliceosome and mRNA-isoforms in PA, and therefore we carried out proteomic and transcriptomic analysis to identify spliceosome components and mRNA isoforms in PA. Methods: Proteomic profile analysis was carried out by nano-HPLC and mass spectrometry with a quadrupole time-of-flight...
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Background Diagnostic testing for coronavirus disease (COVID)-19 is performed using nasopharyngeal swabs. This type of sampling is uncomfortable for the patient, dangerous for health workers, and its high demand has led to a global shortage of swabs. One of the alternative specimens is saliva. However, the optimal conditions for the test have not been established. Methods Reverse transcription-polymerase chain reaction was used to detect the viral genome in saliva samples kept at room temperatur...
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#1Héctor QuezadaH-Index: 13
#2Mariano Martínez-Vázquez (UNAM: National Autonomous University of Mexico)H-Index: 22
Last. Rodolfo García-Contreras (UNAM: National Autonomous University of Mexico)H-Index: 30
view all 8 authors...
Infectious diseases challenge human health. The infectious agents vary from proteins such as prions, simple entities as viruses, unicellular prokaryotic organisms like bacteria, to eukaryotic organ...
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Last. Héctor QuezadaH-Index: 13
view all 8 authors...
Background: Diagnostic testing for coronavirus disease (COVID)-19 is performed using nasopharyngeal swabs. This type of sampling is uncomfortable for the patient, dangerous for health workers, and its high demand has led to a global shortage of swabs. One of the alternative specimens is saliva. However, the optimal conditions for the test have not been established. Methods: Reverse transcription-polymerase chain reaction was used to detect the viral genome in saliva samples kept at room temperat...
Abstract Background Accumulation of lipid aldehydes plays a key role in the etiology of human diseases where high levels of oxidative stress are generated. In this regard, activation of aldehyde dehydrogenases (ALDHs) prevents oxidative tissue damage during ischemia-reperfusion processes. Although omeprazole is used to reduce stomach gastric acid production, in the present work this drug is described as the most potent activator of human ALDH1A1 reported yet. Methods Docking analysis was perform...
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#1Daniel Loarca (UNAM: National Autonomous University of Mexico)H-Index: 3
#2Dánae Díaz (UNAM: National Autonomous University of Mexico)H-Index: 1
Last. Rodolfo García-ContrerasH-Index: 30
view all 11 authors...
Quorum sensing in Pseudomonas aeruginosa controls the production of costly public goods such as exoproteases. This cooperative behavior is susceptible to social cheating by mutants that do not invest in the exoprotease production but assimilate the amino acids and peptides derived by the hydrolysis of proteins in the extracellular media. In sequential cultures with protein as the sole carbon source, these social cheaters are readily selected and often reach equilibrium with the exoprotease produ...
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#1Esaú López-Jácome (UNAM: National Autonomous University of Mexico)H-Index: 5
Last. Rodolfo García-Contreras (UNAM: National Autonomous University of Mexico)H-Index: 30
view all 12 authors...
As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria resistant to all of them exist. In this review, we discuss the release and development of new antibacterial drugs and their properties as well as the current advances in the development of alternative ...
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