Yinyu Shi
Shanghai University
EndocrinologyDensitometryBone remodelingChemistryPhysical therapyPlacebo-controlled studyFemoral neckOsteoporosisOral administrationGenisteinHip fractureFemurDaidzeinParathyroid hormoneEpimediumIntestinal absorptionCalciumBone resorptionMedicineCalcium metabolism
7Publications
4H-index
342Citations
Publications 7
Newest
#1Ge ZhangH-Index: 38
#2Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
Last. Yinyu Shi (SHU: Shanghai University)H-Index: 4
view all 3 authors...
1 CitationsSource
#1Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
#2Ge ZhangH-Index: 38
Last. Xin-Sheng YaoH-Index: 32
view all 10 authors...
Objective To test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium exerted its prevention of estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. Methods Forty-five 12-month-old female Wistar rats were randomly assigned into one sham-operated group and four ovariectomy (OVX) subgroups, i.e. OVX with vehicle (OVX group), OVX with FE (FE group), OVX with calcium supplement (CS group), and OVX with FE and CS. Daily o...
4 CitationsSource
#1Ge Zhang (SHU: Shanghai University)H-Index: 38
#2Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
Last. Yinyu Shi (SHU: Shanghai University)H-Index: 4
view all 3 authors...
Epimedium brevicornum maxim, a nonleguminous medicinal plant, has been found to be rich in phytoestrogen flavonoids. Results from a 24-month randomized double-blind placebo-controlled clinical trial showed that Epimedium-derived phytoestrogen flavonoids were able to exert beneficial effects on preventing bone loss in late postmenopausal women, without resulting in a detectable hyperplasia effect on the endometrium. Introduction: We performed a 24-mo randomized double-blind placebo-controlled cli...
247 CitationsSource
#1Ge Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 38
#2Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
Last. Yinyu ShiH-Index: 4
view all 3 authors...
Recently, we extracted phytoestrogenic fraction (PF) from herbal Epimedium, which is a kind of traditional Chinese medicine (TCM) known as a “bone-strengthening Chinese herb.” This herb has been widely prescribed for musculoskeletal diseases in routine clinical practice of TCM. In this chapter the authors introduce multiple bio-imaging modalities adopted for evaluation of therapeutic efficacy of Epimedium-derived phytoestrogenic fraction (EPF) in two sections. Experimentally, we show that EPF ex...
Source
#1Ge Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 38
#2Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
Last. Kwok-Sui Leung (CUHK: The Chinese University of Hong Kong)H-Index: 39
view all 7 authors...
Aim: Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. Materials and methods: Forty-five 12-month-old female Wistar rats were used and randomly assigned into sham-operated group and four ovariectomy (OVX) subgroups, i.e. OVX with vehicle (OVX group), OVX with FE (FE group), OVX ...
150 CitationsSource
#1Ge Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 38
#2Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
Last. Kwok-Sui Leung (CUHK: The Chinese University of Hong Kong)H-Index: 39
view all 4 authors...
Abstract Background . Conventional testing method for evaluation of rat hip failure force is based on an axial compression approach. However, as the most osteoporotic hip fractures are a result of a lateral fall, it is necessary to establish mechanical testing methods more close to clinical conditions. This study was therefore designed to evaluate the differences in hip mechanical failure force to be tested between ‘axial compression’ and ‘lateral fall configuration’ in a rat proximal femur mode...
9 CitationsSource
#1Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
#2Ge Zhang (CUHK: The Chinese University of Hong Kong)H-Index: 38
Last. P.C. Leung (CUHK: The Chinese University of Hong Kong)H-Index: 17
view all 7 authors...
This study investigated a phytoestrogen-rich herb formula, Xianlinggubao (XLGB) μncluding genistein 510μg/g and daidzein 2500μg/g), concerning prevention of OVX-induced deterioration of musculoskeletal tissues in 11-month-old female Wistar rats, which were randomized into Sham, OVX, and XLGB groups. Daily oral administration of XLGB (250mg/kg/day) started after OVX for 3 months. mRNA of MHC-I IIa IIb of abductor muscle was determined by RT-PCR. The proximal femoral BMD and geometry, microarchite...
83 CitationsSource
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