Samantha K. Atkinson
Hull York Medical School
TonicityClearanceImmunologyMultiplicity of infectionStimulationMucusChronic coughCommon coldRhinovirusAlveolar cellsUpper respiratory tract infectionCarbenoxolonePopulationMucus productionRhinovirus infectionRespiratory infectionRespiratory systemMedicineIntracellularA549 cellRespiratory epitheliumTRPV4Pharmacology
3Publications
2H-index
20Citations
Publications 3
Newest
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Alyn H. Morice (Hull York Medical School)H-Index: 2
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
view all 3 authors...
Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80% of URTI cases, accompanied by heightened airway hypersensitivity, yet no effective treatment currently exists for this infectious cough. The mechanism by which RV causes cough and airway hypersensitivity in URTI is still unknown despite recent advances in potential therapies for chronic cough. The effect of RV-16 infection (MOI 1) on intra...
2 CitationsSource
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Alyn H. MoriceH-Index: 35
Last. Laura R. SadofskyH-Index: 12
view all 3 authors...
Rational and hypothesis: Human rhinovirus (HRV) infections are a major causative agent of upper respiratory tract infection (URTI) and are associated with acute exacerbations of asthma and COPD. URTI is associated with excessive production of mucus within the airway, particularly in sufferers of chronic respiratory conditions. This mucus may lead to altered osmolality within the airway and contribute to hypotonic stimulus of the airway epithelium and airway hypersensitivity leading to cough. Hyp...
Source
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Laura R. Sadofsky (Hull York Medical School)H-Index: 12
Last. Alyn H. Morice (Hull York Medical School)H-Index: 29
view all 3 authors...
Cough is a protective reflex to prevent aspiration and can be triggered by a multitude of stimuli. The commonest form of cough is caused by upper respiratory tract infection and has no benefit to the host. The virus hijacks this natural defence mechanism in order to propagate itself through the population. Despite the resolution of the majority of cold symptoms within 2 weeks, cough can persist for some time thereafter. Unfortunately, the mechanism of infectious cough brought on by pathogenic vi...
20 CitationsSource