Haocheng Lu
University of Michigan
Endothelial stem cellInternal medicineDownregulation and upregulationTFEBEndocrinologyCellChemistryApoptosisAutophagyInflammationVascular diseaseCholesterolVascular smooth muscleAbdominal aortic aneurysmCancer researchDiabetes mellitusMetabolismMedicineTranscription factorBiologyCell biology
31Publications
8H-index
246Citations
Publications 30
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#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
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AIMS The artery contains numerous cell types which contribute to multiple vascular diseases. However, the heterogeneity and cellular responses of these vascular cells during abdominal aortic aneurysm (AAA) progression have not been well characterized. METHODS AND RESULTS Single-cell RNA sequencing (scRNA-seq) was performed on the infrarenal abdominal aortas from C57BL/6J mice at days 7 and 14 post-sham or peri-adventitial elastase-induced AAA. Unbiased clustering analysis of the transcriptional ...
3 CitationsSource
#1Haocheng Lu (UM: University of Michigan)H-Index: 8
#2Jifeng Zhang (UM: University of Michigan)H-Index: 36
Last. Minerva T. Garcia-Barrio (UM: University of Michigan)H-Index: 8
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Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Genome-wide association studies (GWAS) are powerful epidemiological tools to find genes and variants associated with cardiovascular diseases while follow-up biological studies allow to better understand the etiology and mechanisms of disease and assign causality. Improved methodologies and reduced costs have allowed wider use of bulk and single-cell RNA sequencing, human-induced pluripotent stem cells, organoids,...
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#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Ziyi Chang (UM: University of Michigan)H-Index: 4
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
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Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Kruppel-like factor 11 (KLF11) plays an essential role in maintaining vascular homeostasis, at least partially through inhibition of EC inflammatory activation. However, the functions of endothelial KLF11 in AAA remain unknown. Here we found that endothelial KLF11 expression was reduced in the ECs from human aneurysms an...
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#1Huilun Wang (UM: University of Michigan)H-Index: 5
#2Yanhong Guo (UM: University of Michigan)H-Index: 26
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 57
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AIMS Atherosclerosis is the dominant pathologic basis of many cardiovascular diseases. Large genome-wide association studies have identified that single nucleotide polymorphisms proximal to Kruppel-like factor 14 (KLF14), a member of the zinc finger family of transcription factors, are associated with higher cardiovascular risks. Macrophage dysfunction contributes to atherosclerosis development and has been recognized as a potential therapeutic target for treating many cardiovascular diseases. H...
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#1Jinjian Sun (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Yanbo Fan (UM: University of Michigan)H-Index: 21
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Objective: Vascular endothelial cells (ECs) play a critical role in maintaining vascular homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic diseases. TFEB (transcriptio...
3 CitationsSource
#1Die Hu (UM: University of Michigan)H-Index: 3
#2Yanhong Guo (UM: University of Michigan)H-Index: 26
Last. Daoquan Peng (CSU: Central South University)H-Index: 17
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OBJECTIVE Metformin, a first-line drug for treating individuals with type 2 diabetes, exerts beneficial effects on cholesterol-lowering, yet its precise mechanism has not been established. Approach and Results: In 2 dyslipidemia mouse models, administration of metformin significantly decreased serum cholesterol and PCSK9 (proprotein convertase subtilisin/kexin type 9) levels, accompanied by decreased expression of PCSK9 in both mRNA and protein levels resulting in a 3-fold increase of LDLR (low-...
1 CitationsSource
#1Haocheng Lu (UM: University of Michigan)H-Index: 8
#2Jinjian Sun (UM: University of Michigan)H-Index: 3
Last. Yanbo Fan (University of Cincinnati Academic Health Center)
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Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest that TFEB regulates homeostasis in the cardiovascular system and shows beneficial effects on CVDs, including atherosclerosis, aortic aneurysm, postischemic angiogenesis, and cardiotox...
1 CitationsSource
#1Oren Rom (UM: University of Michigan)H-Index: 15
#2Yuhao Liu (UM: University of Michigan)H-Index: 4
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 57
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Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the causes for reduced glycine, its role as a causative factor, and its therapeutic potential remain unclear. We performed transcriptomics in livers from humans and mice with NAFLD and found suppression of glycine biosynthetic genes, primarily alanine-glyoxyl...
5 CitationsSource
#1Ida Surakka (UM: University of Michigan)H-Index: 34
#2Lars G. Fritsche (UM: University of Michigan)H-Index: 38
Last. Cristen J. Willer (UM: University of Michigan)H-Index: 78
view all 26 authors...
A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the discovery cohort for loss-of-function (LoF) mutations by sequencing a subset of the Nord-Trondelag Health Study, followed by imputation in the remaining sample (N = 19,705), and identified ten known BMD loci. However, one previously unreported variant, LoF mutation in MEPE, p.(Lys...
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