Jason Tasse
French Institute of Health and Medical Research
Internal medicineChemistryImmunologyGentamicinTeicoplaninMethicillin-resistant Staphylococcus aureusDaptomycinVancomycinStaphylococcus aureusCloxacillinFusidic acidVirulence factorLinezolidMethicillin resistanceCarriagePersistence (computer science)Veterinary medicineAntimicrobialAntibioticsBiofilmVirulenceMedicineIntracellularBiologyMicrobiologyGastroenterology
26Publications
10H-index
290Citations
Publications 23
Newest
#1Marie Chavignon (French Institute of Health and Medical Research)
Last. Marine Butin (French Institute of Health and Medical Research)H-Index: 7
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BACKGROUND In neonatal intensive care units (NICUs), hygiene and disinfection measures are pivotal to protect neonates from nosocomial infections. This study aimed to evaluate the efficacy of the classical incubators disinfection procedure and to follow-up neonates housed in the incubators for the development of late-onset sepsis (LOS). METHODS In a tertiary NICU, 20 incubators were monitored for bacterial contamination at three times: before disinfection, after disinfection, and 24 h after turn...
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#1Pierre Chauvelot (French Institute of Health and Medical Research)
#2Tristan Ferry (French Institute of Health and Medical Research)H-Index: 34
Last. Florent Valour (French Institute of Health and Medical Research)H-Index: 17
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Introduction: Corynebacteria represent often-neglected etiological agents of post-traumatic and/or post-operative bone and joint infection (BJI). We describe here clinical characteristics and bacteriological determinants of this condition. Methods: A retrospective cohort study described characteristics, outcome and determinants of treatment failure of all patients with proven Corynebacterium spp. BJI (i.e., ≥2 culture-positive gold-standard samples). Available strains were further characterized ...
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#1Elodie OlivaresH-Index: 3
#2Jason TasseH-Index: 10
Last. Thierry BernardiH-Index: 14
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Biofilms are characterized by high tolerance to antimicrobials. However, conventional antibiograms are performed on planktonic microorganisms. Through the clinical Biofilm Ring Test® (cBRT), initially aimed to measure the adhesion propensity of bacteria, we discerned a variable distribution of biofilm-producer strains among P. aeruginosa samples isolated from expectorations of cystic fibrosis (CF) patients. Despite a majority of spontaneous adherent isolates, few strains remained planktonic afte...
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#1Alan Diot (École normale supérieure de Lyon)H-Index: 13
#2Virginie Dyon-Tafani (École normale supérieure de Lyon)H-Index: 1
Last. Frédéric Laurent (École normale supérieure de Lyon)H-Index: 19
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Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated S. argenteus strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in compariso...
1 CitationsSource
#1Lélia Abad (UCBL: Claude Bernard University Lyon 1)H-Index: 3
#2Jérôme Josse (École normale supérieure de Lyon)H-Index: 12
Last. Florent ValourH-Index: 17
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BACKGROUND: Targeting biofilm-embedded and intraosteoblastic Staphylococcus aureus, rifampicin gained a pivotal role in bone and joint infection (BJI) treatment. Two other rifamycins, rifabutin and rifapentine, may represent better-tolerated alternatives, but their activity against bacterial reservoirs associated with BJI chronicity has never been evaluated. OBJECTIVES: To evaluate the activities of rifampicin, rifabutin and rifapentine in osteoblast infection models. METHODS: Using three S. aur...
5 CitationsSource
#1Boun Kim Tan (Paris V: Paris Descartes University)H-Index: 1
#2Yoann Crabol (Paris V: Paris Descartes University)H-Index: 6
Last. Loïc Guillevin (Paris V: Paris Descartes University)H-Index: 132
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OBJECTIVE: To identify the role of Staphylococcus aureus (SA) or its intracellular small-colony variant phenotype (SCV) with co-trimoxazole (CTX) or ANCA-associated vasculitis (AAV) activity. METHODS: All consecutive AAV patients with granulomatosis with polyangiitis (GPA), eosinophilic GPA or microscopic polyangiitis, followed at the French National Vasculitis Referral Center (09/2012-05/2013), and hospitalized non-AAV controls, exclusively for SA/SCV carriage comparisons, were enrolled. All ha...
5 CitationsSource
#1Lélia AbadH-Index: 3
#2Virginie Tafani (École normale supérieure de Lyon)H-Index: 3
Last. Florent ValourH-Index: 17
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OBJECTIVES: Prolonged use of linezolid for bone and joint infection (BJI) is limited by its long-term toxicity. The better safety profile of tedizolid, a recently developed oxazolidinone, could offer an alternative. However, its efficacy against biofilm-embedded and intracellular Staphylococcus aureus, the two main bacterial reservoirs associated with BJI chronicity, is unknown. METHODS: Using three S. aureus strains (6850 and two clinical BJI isolates), linezolid and tedizolid were compared reg...
12 CitationsSource
#1Jacques Bietrix (L'Arche)H-Index: 1
#2Camille KolendaH-Index: 7
Last. Frédéric LaurentH-Index: 19
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Background. Methicillin resistance in Staphylococcus aureus (MRSA) is classically conferred by the acquisition of the mecA gene encoding an additional penicillin binding protein with low affinity for beta-lactams. A mecA variant, named mecC, was described in 2011. MRSA isolates harboring mecC of both animal and human origin have since been collected in different European countries. In France, animal cases were reported in 4 dairy farms between 2008 and 2013 in the Meurthe-et-Moselle county, all ...
6 CitationsSource
#1Lélia AbadH-Index: 3
Last. Florent ValourH-Index: 17
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Aim Leading etiology of Bone and Join infections (BJI), Staphylococcus aureus (SA) is responsible for difficult-to-treat infections mainly because of three persistence factors: (i) biofilm formatio...
#1Jason Tasse (French Institute of Health and Medical Research)H-Index: 10
#2Sophie Trouillet-Assant (UCBL: Claude Bernard University Lyon 1)H-Index: 10
Last. Frédéric Laurent (UCBL: Claude Bernard University Lyon 1)H-Index: 19
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: Biofilm formation is a critical virulence factor responsible for treatment failure and chronicity in orthopaedic device-related infections (ODIs) caused by Staphylococcus aureus. Clonal lineages differ in terms of their biofilm forming capacities. The aim of this study was to investigate the correlation between the clonal complex (CC) affiliation and biofilm phenotype of 30 clinical S. aureus isolates responsible of ODI based on i) early biofilm formation using BioFilm Ring Test® and mature bi...
9 CitationsSource