Jinyeong Yu
Kyung Hee University
Proto-oncogene tyrosine-protein kinase SrcTransforming growth factorDownregulation and upregulationCell migrationCadherinStromal cellChemistryExtracellular matrixMesenchymal stem cellProgenitor cellSubstance PDermal fibroblastBone marrowWound healingAngiogenesisStem cellMesenchymal stem cell migrationCancer researchMedicineCell biology
11Publications
5H-index
79Citations
Publications 11
Newest
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Sanghyuk Choi (Kyung Hee University)H-Index: 3
Last. Ki-Sook ParkH-Index: 18
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Cancer cachexia is a multifactorial systemic inflammation disease caused by complex interactions between the tumor and host tissues via soluble factors. However, whether cancer cachexia affects the bone marrow, in particular the hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), remains unclear. Here, we investigated the bone marrow and bone in a cancer cachexia animal model generated by transplanting Lewis lung carcinoma cells. The number of bone marrow mononuclear cells (BM-MNC...
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#1Sanghyuk ChoiH-Index: 3
#2Jinyeong YuH-Index: 5
Last. Ki-Sook ParkH-Index: 18
view all 4 authors...
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#1Donghyun Nam (Kyung Hee University)H-Index: 3
#2Aran Park (Kyung Hee University)H-Index: 1
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 7 authors...
Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or...
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#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Donghyun Nam (Kyung Hee University)H-Index: 3
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 3 authors...
Abstract Diabetes induces cellular dysfunction in dermal fibroblasts, such as impairment in migration, which is a major cause of chronic wound. Here, we demonstrated that the migration of human dermal fibroblasts was impaired under a high glucose culture condition. Substance P (SP) rescued the impaired migration of the fibroblasts. The activity of Rac1, Rho-associated kinase (ROCK), and Src was required for SP-mediated rescue of fibroblast migration. SP activated Rac1 and Src, whereas, NSC23766,...
3 CitationsSource
#1Sanghyuk Choi (Kyung Hee University)H-Index: 3
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 9 authors...
Bone morphogenetic protein (BMP) signaling and Notch signaling play important roles in tumorigenesis in various organs and tissues, including the breast. BMP-4 enhanced epithelial mesenchymal transition (EMT) and stem cell properties in both mammary epithelial cell line and breast carcinoma cell line. BMP-4 increased the expression of EMT biomarkers, such as fibronectin, laminin, N-cadherin, and Slug. BMP-4 also activated Notch signaling in these cells and increased the sphere forming efficiency...
9 CitationsSource
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Hye Min Kim (Kyung Hee University)H-Index: 2
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
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Abstract Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-β. However, the roles of i...
3 CitationsSource
#1Maria Jose Dubon (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook ParkH-Index: 18
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Transforming growth factor-beta (TGF-β) induces the migration and mobilization of bone marrow-derived mesenchymal stem cells (BM-MSCs) to maintain bone homeostasis during bone remodeling and facilitate the repair of peripheral tissues. Although many studies have reported the mechanisms through which TGF-β mediates the migration of various types of cells, including cancer cells, the intrinsic cellular mechanisms underlying cellular migration, and mobilization of BM-MSCs mediated by TGF-β are uncl...
27 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 3 authors...
: Wound healing is delayed in diabetes due to a number of factors, including impaired angiogenesis and poor dermal healing. The present study demonstrated that subcutaneous administration of substance P (SP) accelerates wound healing in db/db type 2 diabetic mice (db/db mice). SP injection (10 nM/kg, subcutaneously) enhanced angiogenesis, induced the mobilization of endothelial progenitor cells (EPCs) and increased the number of EPC‑colony forming units (EPC‑CFUs) in the bone marrow of db/db mic...
13 CitationsSource
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Sanghyuk Choi (Kyung Hee University)H-Index: 3
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 4 authors...
Dermal fibroblasts play essential roles in wound healing and their dysfunction has been shown to be associated with impaired wound healing in diabetes. In the present study, we aimed at investigating whether Yes-associated protein (YAP), a mediator of mechanotransduction in dermal fibroblasts, is associated with impaired wound healing in diabetic mice. Compared with that in the control, the rate of wound contraction was decreased twofold in db/db type 2 diabetic mice (db/db mice). To mimic diabe...
2 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 4 authors...
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP). Our study shows that systemic co-treatment of SP and thiorphan, an inhibitor of NEP synergically increased the number of α-smooth muscle actin positive-blood vessels in skin wounds. However, there was no...
11 CitationsSource