Atsuhito Uneda
Okayama University
GeneInternal medicineRadiologyNeurosurgerySurgeryPathologyMagnetic resonance imagingCellIn vivoOcclusionMyelopathyBevacizumabGliomaCerebral infarctionAngiogenesisSpinal cordDifferential diagnosisCancer researchMedicineCell cultureBiology
42Publications
8H-index
195Citations
Publications 43
Newest
#1Yasuhiko HattoriH-Index: 5
Last. Yosuke ShimazuH-Index: 6
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#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
4 CitationsSource
#1Satoru Yabuno (Okayama University)H-Index: 2
#2Satoshi Kawauchi (Okayama University)H-Index: 3
Last. Shohei KohnoH-Index: 15
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#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Koji HirashitaH-Index: 6
Last. Isao Date (Okayama University)H-Index: 58
view all 7 authors...
Methotrexate (MTX) is an immunosuppressor that is widely used to treat autoimmune diseases, including rheumatoid arthritis (RA). However, it can have serious adverse effects including a lymphoma: MTX-associated lymphoproliferative disorder (MTX-LPD). Extranodal lesions are common in MTX-LPD patients. However, MTX-LPD in the central nervous system (CNS) is extremely rare with few reported cases. Here, we describe a case of primary CNS MTX-LPD in a patient with RA, with a review of the literature....
1 CitationsSource
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
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Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of angiogenesis and perivascular invasion. Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clusterin...
4 CitationsSource
#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 7 authors...
Intracranial mesenchymal chondrosarcoma (MCS) is a rare neoplasm. The diagnosis of MCS is confirmed by the presence of a biphasic pattern on histological examination, comprising undifferentiated small round cells admixed with islands of well-differentiated hyaline cartilage; however, a differential diagnosis may be challenging in some cases. A 28-year-old woman with a 2-month history of headache was referred to our hospital. Radiologic studies showed an extra-axial lobulated mass composed of cal...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2K. Fujii (Okayama University)H-Index: 2
Last. Isao Date (Okayama University)H-Index: 58
view all 11 authors...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Kentaro Fujii (Okayama University)H-Index: 8
Last. Isao Date (Okayama University)H-Index: 58
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INTRODUCTION Expression of the gene encoding reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) was reported to be reduced in a variety of human cancer cells. We previously examined the antitumor effect of an adenoviral vector carrying REIC/Dkk-3 gene (Ad-CAG-REIC). Recently, a novel adenoviral vector expressing REIC/Dkk-3 has also been developed based on the cytomegalovirus promoter-driven super gene expression system (Ad-SGE-REIC). We evaluated the anti-glioma effect of the Ad-SG...
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#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu IchikawaH-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
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#1Yusuke Tomita (Okayama University)H-Index: 6
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 13 authors...
Anti-vascular endothelial growth factor treatments such as bevacizumab have demonstrated convincing therapeutic advantage in glioblastoma patients. However, bevacizumab has also been reported to induce invasiveness of glioma. In this study, we examined the effects of Rapid Antiangiogenesis Mediated By Oncolytic virus (RAMBO), an oncolytic herpes simplex virus-1 expressing vasculostatin, on bevacizumab-induced glioma invasion. The effect of the combination of RAMBO and bevacizumab in vitro was as...
10 CitationsSource