Giovanni Centonze
University of Milan
CancerInternal medicinePathologyOncologymicroRNACell typeImmunohistochemistryLung cancerImmunotherapyKi-67CisplatinMetastasisNeuroendocrine tumorsPD-L1KRASConfidence intervalCancer researchColorectal cancerCarcinogenesisMedicineBiologyImmune systemGastroenterologyCancer cell
Publications 49
To develop predictive models of side effect occurrence in GEPNET treated with PRRT. Metastatic GEPNETs patients treated in our centre with PRRT (177Lu-Oxodotreotide) from 2019 to 2020 were considered. Haematological, liver and renal toxicities were collected and graded according to CTCAE v5. Patients were grouped according with ECOG-PS, number of metastatic sites, previous treatment lines and therapies received before PRRT. A FLIC model with backward selection was used to detect the most relevan...
#1Cristina BorziH-Index: 8
#2Elisa Caiola (Mario Negri Institute for Pharmacological Research)H-Index: 14
Last. Massimo MoroH-Index: 18
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#1Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 21
#2Francesca PontisH-Index: 1
Last. Cristina BorziH-Index: 8
view all 17 authors...
Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool for lung cancer management. We identified seven miRNAs, including miR-126-3p and miR-221-3p, that are deregulated in tumours compared with normal tissues in a series of 38 non-small-cell lung cancer patients. A negative correlatio...
Background null Extracellular vesicles (EVs) containing specific subsets of functional biomolecules are released by all cell types and analysis of circulating EVs can provide diagnostic and prognostic information. To date, little is known regarding the role of EVs both as biomarkers and potential key players in human lung cancer. null Methods null Plasma EVs were isolated from 40 cancer-free heavy-smokers classified according to a validated 24-microRNA signature classifier (MSC) at high (MSCpos-...
#1Antonino BelfioreH-Index: 57
#2Giovanni CentonzeH-Index: 12
Last. Massimo MilioneH-Index: 33
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Background: On December 2019, an outbreak of atypical pneumonia, known as COVID-19, was identified in Wuhan, China. This disease, characterized by the rapid human-to-human transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly in more than 200 countries. Northern Italy’s regions have been hit hard in terms of deaths. Here, we report the experience of the Pathology Department of the Fondazione IRCCS Istituto Nazionale Tumori (INT) in Milan, the first ...
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Patrick Maisonneuve (IEO: European Institute of Oncology)H-Index: 136
Last. Stefano Di DomenicoH-Index: 10
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Updates in classification of gastro-entero-pancreatic neuroendocrine neoplasms better reflect the biological characteristics of these tumours. In the present study, we analysed the characteristics of neuroendocrine tumours that could aid in a more precise stratification of risk groups. In addition, we have highlighted the importance of grade (re)assessment based on investigation of secondary tumour lesions. Two hundred and sixty-four cases of neuroendocrine tumours of gastro-entero-pancreatic or...
#1Giulia BertoliniH-Index: 13
#2Valeria Cancila (University of Palermo)H-Index: 12
Last. Luca RozH-Index: 32
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Abstract Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironments. Here, we investigated the interconnected pathways underlying the promotion of cisplatin-induced metastases. In tumor-free mice, cisplatin treatment resulted in an expansion in the bone-marrow of CCR2+CXCR4+Ly6Chigh inflammatory monocytes (IM) and ...
#3Emma V. Carrington (Imperial College London)H-Index: 12
#10M. P. Romano (UNIPD: University of Padua)H-Index: 10
Abstract Background Mixed adeno-neuroendocrine carcinomas (MANEC) are a subgroup of mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) described as mixed neoplasms containing dual neuroendocrine and non-neuroendocrine components. The aim of this study was to appraise the prevalence of MANEC in the lower gastrointestinal (GI) tract and provide reliable estimates of survival. Method A systematic review was undertaken in accordance with PRISMA guidelines using PubMed, Embase, Cochrane Librar...
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