Jia Miao
Sichuan University
ExcretionPharmacodynamicsPharmacokineticsInternal medicineLatin squareDoseChemistryAdverse effectCmaxPlaceboInhalationPhosphateDosingTolerabilityCefetametUrineMetered-dose inhalerRegimenPopulationHealthy volunteersPhases of clinical researchAnesthesiaBioequivalenceConfidence intervalSodiumMedicineCrossover studyGastroenterologyPharmacology
20Publications
3H-index
20Citations
Publications 23
Newest
#1Jia Miao (Sichuan University)H-Index: 3
#2Ping Fu (Sichuan University)
Last. Li ChenH-Index: 1
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Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI) on dorzagliatin's pharmacokinetics (PKs) and safety, and to guide appropriate clinical dosing in patients with diabetic kidney disease, including end-stage renal disease (ESRD). Based on the results from physiologically-based pharmacokinetic mode...
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#1Chao Hu (Sichuan University)H-Index: 2
#2Xiaofeng Ou (Sichuan University)
Last. Jia Miao (Sichuan University)H-Index: 3
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The effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated. In this open-label, randomized, two-way cross-over study, subjects received initial doses of continuous ciprofol/propofol as an infusion for 30 min in part 1 (n = 8) and a bolus dose in part 2 (n = 8) followed by maintenance infusions for a total of 4 h in part 1 and 12 h in part 2. Each subject participated in both parts with a was...
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#1Tian-Tao Gao (Sichuan University)
Last. Jin XiangH-Index: 6
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#1Zhong-ping Gou (Sichuan University)H-Index: 2
#2Yun-Li Zhao (CAS: Chinese Academy of Sciences)H-Index: 16
Last. Ping Feng (Sichuan University)H-Index: 2
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CONTEXT Capsule of alkaloids from the leaf of Alstonia scholaris (L.) R.Br. (Apocynaceae) (CALAS) is a new investigational botanical drug (No. 2011L01436) for bronchitis, post-infectious cough and asthma. OBJECTIVE To observe the clinical safety and tolerability of CALAS. MATERIALS AND METHODS Subjects were assigned to eight cohorts, and each received randomly CALAS or placebo in one of single ascending dose (SAD) of 8, 40, 120, 240, 360, 480, or in one of multiple ascending dose (MAD) of 40 or ...
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#1Zhu Luo (Sichuan University)H-Index: 2
#2Chao Hu (Sichuan University)H-Index: 2
Last. Mao-Zhi Liang (Sichuan University)H-Index: 6
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Abstract Background Bencycloquidium bromide (BCQB) is a novel inhaled anticholinergic bronchodilator with high selectivity for muscarinic M3 receptor. BCQB's potential utility of for therapy in Chronic obstructive pulmonary disease (COPD) has been indicated in pre-clinical studies. Purpose To investigate the initial safety, tolerability and pharmacokinetics of BCQB delivered via pressurised Metered Dose Inhaler (pMDI) in healthy subjects. Methods This study consisted of single-ascending-dose (SA...
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#1Qi Shen (Sichuan University)H-Index: 1
#2Chao Hu (Sichuan University)H-Index: 2
Last. Zhu Luo (Sichuan University)H-Index: 1
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Abstract Background : Ammoxetine is a novel selective serotonin and norepinephrine reuptake inhibitor. Preclinical studies have indicated the potential utility of ammoxetine for therapy in major depressive disorder. Purpose : To investigate the first-in-human safety, tolerability, and pharmacokinetics (PK) of ammoxetine in healthy subjects and evaluate the effect of CYP2C19 polymorphisms on metabolism of ammoxetine. Methods : In this randomized, double-blind, placebo-controlled phase I study, he...
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#1Chao Hu (Sichuan University)H-Index: 2
#2Jia Miao (Sichuan University)H-Index: 3
Last. Zhu Luo (Sichuan University)H-Index: 2
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Abstract Background BDP/FF/GB pMDI is a novel triple fixed-dose combination of extra-fine inhalation aerosol beclomethasone dipropionate (BDP)/formoterol fumarate (FF)/glycopyrronium bromide (GB). Limited data on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of BDP/FF/GB fixed-dose combination in healthy subjects was available. Purposes This study aimed to evaluate the pharmacokinetics, pharmacodynamics and safety of BDP/FF/GB pMDI in healthy Chinese subjects. Methods This is an o...
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#1Zhu Luo (Sichuan University)H-Index: 2
#2Jia Miao (Sichuan University)H-Index: 3
Last. Yali Shen (Sichuan University)H-Index: 2
view all 7 authors...
Background and Objectives Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and the original extended release (ER) formulation tablets administered with an opioid antagonist in patients with chronic pain.
Source
#1Shi-Bei-Lei Lin (Sichuan University)
#2Chao Hu (Sichuan University)H-Index: 2
Last. Mao-Zhi Liang (Sichuan University)H-Index: 6
view all 10 authors...
OBJECTIVE To study the pharmacokinetic profile of phentolamine mesylate injection in healthy Chinese volunteers. METHODS A total of 16 healthy volunteers were randomly divided into two groups, each receiving anterior teeth submucosal infiltration anesthesia and inferior alveolar nerve block anesthesia, respectively. The participants were injected with 0.9 mL, 1.8 mL, and 3.6 mL of 2% lidocaine HCl with 1∶100 000 epinephrine over three periods sequentially, followed by corresponding sequential in...
#1Chao Hu (Sichuan University)H-Index: 2
#2Jing Zheng (Sichuan University)
Last. Mao-Zhi Liang (Sichuan University)H-Index: 6
view all 10 authors...
OBJECTIVE: To compared the differences in pharmacokinetics of phosphate retagliptin tablets in patients with varying degrees of renal dysfunction. METHODS: A total of 32 patients were categorized into five groups according to their renal function: normal,mild dysfunction, moderate dysfunction,severe dysfunction,and end stage renal dysfunction (ESRD). All of the patients took a single dose of 50 mg phosphate retagliptin tablet. Their plasma and urinary concentrations of phosphate retagliptin (SP2...
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