Gennady V. Roshchupkin
Erasmus University Rotterdam
Genome-wide association studyBrain morphometryPsychologyHeritabilityNeuroscienceCognitionGenetic associationVoxel-based morphometryRotterdam StudyDementiaWhite matterPopulationComputer scienceVoxelNeuroimagingMedicineEvolutionary biologyLocus (genetics)BiologyGenetic architecture
Publications 48
#1Edith Hofer (Medical University of Graz)H-Index: 27
#2Gennady V. Roshchupkin (EUR: Erasmus University Rotterdam)H-Index: 10
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
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1 CitationsSource
#2Mohammad Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 27
Last. Hieab H.H. Adams (UPF: Pompeu Fabra University)H-Index: 25
view all 6 authors...
Background. Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood-onset disorder that can persist into adult life. Most genetic studies have focused on investigating biological mechanisms of ADHD during childhood. However, little is known about whether genetic variants associated with ADHD influence structural brain changes throughout adulthood. Methods. Participant of the study were drawn from a population-based sample of 3,220 healthy individuals drawn from the Rotterdam Study, with a...
#1Nicola J. Armstrong (Murdoch University)H-Index: 37
#2Karen A. Mather (UNSW: University of New South Wales)H-Index: 34
Last. Paul A. Nyquist (NIH: National Institutes of Health)H-Index: 22
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Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first st...
9 CitationsSource
#1Jean Shin (U of T: University of Toronto)H-Index: 11
#2Shaojie Ma (Yale University)H-Index: 2
Last. Tomáš Paus (U of T: University of Toronto)H-Index: 93
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We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included th...
2 CitationsSource
#1Rachel M. Brouwer (UU: Utrecht University)H-Index: 37
#2Marieke Klein (UCSD: University of California, San Diego)H-Index: 12
Last. Hilleke E. Hulshoff Pol (UU: Utrecht University)H-Index: 76
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Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal ma...
4 CitationsSource
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 10
#2Neda Jahanshad (SC: University of Southern California)H-Index: 48
Last. Sarah E. Medland (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 85
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
85 CitationsSource
#1Hata Karamujić-Čomić (EUR: Erasmus University Rotterdam)H-Index: 2
#2Shahzad Ahmad (EUR: Erasmus University Rotterdam)H-Index: 10
Last. Cornelia M. van Duijn (Clinical Trial Service Unit)H-Index: 108
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#1Sven J. van der Lee (EUR: Erasmus University Rotterdam)H-Index: 33
#2Maria J. Knol (EUR: Erasmus University Rotterdam)H-Index: 6
Last. Charles DeCarli (UC Davis: University of California, Davis)H-Index: 113
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Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocamp...
8 CitationsSource
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 25
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 89
view all 289 authors...
1 CitationsSource
#2Hieab H.H. Adams (EUR: Erasmus University Rotterdam)H-Index: 25
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 89
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Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysi...
55 CitationsSource
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