Chen Yang
Chinese Academy of Sciences
Particle physicsOpticsPhysicsInternal medicineParticle decayLeptonNuclear physicsChemistryMaterials scienceCollider Detector at FermilabProduction (computer science)TevatronComputer sciencePair productionOptoelectronicsMedicineNanowireBiology
Publications 602
#1Weixia ZhangH-Index: 22
#2Yimin HuangH-Index: 10
Last. Chen YangH-Index: 74
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#1Qing Xu (CAS: Chinese Academy of Sciences)H-Index: 6
#2Feng Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Chen Yang (CAS: Chinese Academy of Sciences)H-Index: 74
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Abstract null null Quick and effective elimination of drug-resistant bacteria and simultaneous repairing the infectious tissue remain challenging in clinics. In this study, multifunctional glycol chitosan and polydopamine coated copper-doped mesoporous silica (MCS@PDA@GCS) nanoparticles with near-infrared (NIR) photothermal conversion ability and bacteria-targeting property are prepared. When infection occurred, the environment becomes acidic, and MCS@PDA@GCS nanoparticles with pH-sensitive coul...
#1Ziyun HuangH-Index: 2
#2Yanan ShiH-Index: 3
Last. Zhixiang WeiH-Index: 55
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Despite the remarkable progress achieved in the field of non-fullerene acceptor (NFA)-based organic photovoltaics (OPVs) in recent years, the large energy loss remains the major factor limiting the power conversion efficiency (PCE) of in OPVs. Although many studies on polymer OPVs have been reported, low energy loss systems with high efficiency are rarely reported all-small-molecule organic-solar-cells (ASM-OSCs). This is partially because low energetic offset between donors and acceptors is usu...
#1Lingling XieH-Index: 2
#2Tianyi LiH-Index: 4
Last. Chen YangH-Index: 74
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: Purpose: To study the alteration of microglial subtypes, the representative markers of microglia, and the morphology of dendrites and dendritic spines after acute status epilepticus (SE) and during recurrent seizures. Methods: A mouse kainate-induced SE model was used. Dendrites and dendritic spines of granule neurons in the dentate gyrus (DG)subregion and pyramidal neurons in the cornu ammonis (CA)1 and cornu ammonis (CA)3 subregions of the hippocampus were visualized by Golgi staining. Synap...
#1Chen Yang (USTC: University of Science and Technology of China)H-Index: 74
#2Zhi-Yuan Zhou (USTC: University of Science and Technology of China)H-Index: 25
Last. Bao-Sen Shi (USTC: University of Science and Technology of China)H-Index: 31
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Optical interference is not only a fundamental phenomenon that has enabled new theories of light to be derived but it has also been used in interferometry for the measurement of small displacements, refractive index changes and surface irregularities. In a two-beam interferometer, variations in the interference fringes are used as a diagnostic for anything that causes the optical path difference (OPD) to change; therefore, for a specified OPD, greater variation in the fringes indicates better me...
#1Yanan Liu (TJU: Tianjin University)H-Index: 1
#2Jianqi Zhang (CAS: Chinese Academy of Sciences)H-Index: 55
Last. Zhixiang Wei (CAS: Chinese Academy of Sciences)H-Index: 55
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#1Cheng Zong (BU: Boston University)H-Index: 19
#2Ran Cheng (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
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Surface-enhanced Raman scattering (SERS) spectroscopy has been used extensively to study biology, chemistry, and materials. However, a point-by-point SERS mapping is time-consuming, taking minutes to hours for large-scale imaging. Here, we report a wide-field surface-enhanced coherent anti-Stokes Raman scattering (WISE-CARS) microscopy for monitoring nanotags in live cells and label-free detection of metabolic molecules. The WISE-CARS microscope achieves an imaging speed as fast as 120 frames pe...
#3Haibo Zhang (CAS: Chinese Academy of Sciences)H-Index: 32
Obesity is an epidemic affecting 13% of the global population and increasing the risk of many chronic diseases. However, only several drugs are licensed for pharmacological intervention for the treatment of obesity. As a master regulator of metabolism, the therapeutic potential of AMPK is widely recognized and aggressively pursued for the treatment of metabolic diseases. We found that elaiophylin (Ela) rapidly activates AMPK in a panel of cancer-cell lines, as well as primary hepatocytes and adi...
Background null Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims to identify novel therapeutic strategies for HCC patients. null Methods null Integrated bioinformatics analyses and a non-biased CRISPR loss of function genetic screen were performed to identify p...
#2Bing Chen (SJTU: Shanghai Jiao Tong University)H-Index: 37
Most patients experience severe hematological toxicities during treatment with gemcitabine; thus, preventing such toxicities would improve the treatment effects and patients' quality of life. We analyzed 13 polymorphisms in the transporters, metabolizing enzymes, targets and genes involved in DNA damage and the folate pathway among 132 patients treated with gemcitabine and studied their association with the severity of the hematological toxicities. Single-locus analysis showed that the SNPs RRM1...
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