Helen McShane
University of Oxford
AntigenVirologyIntensive care medicineImmunologyVaccinationT cellMycobacterium tuberculosisBCG vaccineMycobacterium bovisELISPOTTuberculosis vaccinesDiseaseImmunityImmunogenicityTuberculosisVacciniaPopulationClinical trialMedicineBiologyImmune system
Publications 239
#1Daniel Freeman (University of Oxford)H-Index: 86
#2Sinéad Lambe (Oxford Health NHS Foundation Trust)H-Index: 8
Last. Samantha Vanderslott (University of Oxford)H-Index: 7
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BACKGROUND: When vaccination depends on injection, it is plausible that the blood-injection-injury cluster of fears may contribute to hesitancy. Our primary aim was to estimate in the UK adult population the proportion of COVID-19 vaccine hesitancy explained by blood-injection-injury fears. METHODS: In total, 15 014 UK adults, quota sampled to match the population for age, gender, ethnicity, income and region, took part (19 January-5 February 2021) in a non-probability online survey. The Oxford ...
3 CitationsSource
This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals within 10 weeks of challenge, whereas all six vaccinated animals controlled disease for 26 weeks. Three unvaccinated animals limited disease progression, highlighting the intrinsic ability of this macaque species to control diseas...
#2A Noé (University of Oxford)
#4C Tamandjou (UCT: University of Cape Town)
Last. A C Eziefula (University of Sussex)
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Higher academic institutions in the UK need to drive improvements in equity, diversity, and inclusion (EDI) through sustainable practical interventions. A broad view of inclusivity is based on an intersectional approach that considers race, geographical location, caring responsibilities, disability, neurodiversity, religion, and LGBTQIA+ identities. We describe the establishment of a diverse stakeholder group to develop practical grass-roots recommendations through which improvements can be adva...
#1Daniel Freeman (University of Oxford)H-Index: 86
Last. Sinéad Lambe (University of Oxford)H-Index: 8
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Summary Background The effectiveness of the COVID-19 vaccination programme depends on mass participation: the greater the number of people vaccinated, the less risk to the population. Concise, persuasive messaging is crucial, particularly given substantial levels of vaccine hesitancy in the UK. Our aim was to test which types of written information about COVID-19 vaccination, in addition to a statement of efficacy and safety, might increase vaccine acceptance. Methods For this single-blind, para...
2 CitationsSource
#1Michael Riste (University of Oxford)H-Index: 2
#1Michael J RisteH-Index: 3
Last. Helen McShaneH-Index: 64
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The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to be safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered candidate TB vaccines in this population. We carried out a Phase I trial to evaluate the safety and immunogenicity of MVA85A delivered by aerosol in UK adults with LTBI (NCT02532036). Two volunteers were recruited, and the vaccine was well-tolerated with no sa...
#1Andrew Chadwick (Lboro: Loughborough University)H-Index: 37
#2Johannes Kaiser (Lboro: Loughborough University)
Last. Ly-Mee Yu (University of Oxford)H-Index: 56
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We explore the implications of online social endorsement for the Covid-19 vaccination program in the United Kingdom. Vaccine hesitancy is a long-standing problem, but it has assumed great urgency d...
#1Laurence Roope (University of Oxford)H-Index: 8
#1Roope Lsj. (University of Oxford)H-Index: 1
Last. Philip Clarke (University of Oxford)H-Index: 47
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The COVID-19 pandemic has shed a spotlight on the resilience of healthcare systems, and their ability to cope efficiently and effectively with unexpected crises. If we are to learn one economic lesson from the pandemic, arguably it is the perils of an overfocus on short-term allocative efficiency at the price of lack of capacity to deal with uncertain future challenges. In normal times, building spare capacity with 'option value' into health systems may seem inefficient, the costs potentially ex...
#1Rachel TannerH-Index: 18
#2Emily Hoogkamer (PHE: Public Health England)
Last. Helen McShaneH-Index: 64
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The only currently available approach to early efficacy testing of tuberculosis (TB) vaccine candidates is in vivo preclinical challenge models. These typically include mice, guinea pigs and non-human primates (NHPs), which must be exposed to virulent M.tb in a ‘challenge’ experiment following vaccination in order to evaluate protective efficacy. This procedure results in disease development and is classified as ‘Moderate’ in severity under EU legislation and UK ASPA licensure. Furthermore, expe...
#1Laura SibleyH-Index: 8
#2Andrew WhiteH-Index: 11
Last. S SharpeH-Index: 1
view all 19 authors...
1 CitationsSource
#1Hazel Morrison (University of Oxford)H-Index: 2
#2Helen McShane (University of Oxford)H-Index: 64
Regardless of the eventual site of disease, the point of entry for Mycobacterium tuberculosis (M.tb) is via the respiratory tract and tuberculosis (TB) remains primarily a disease of the lungs. Immunological biomarkers detected from the respiratory compartment may be of particular interest in understanding the complex immune response to M.tb infection and may more accurately reflect disease activity than those seen in peripheral samples. Studies in humans and a variety of animal models have show...
1 CitationsSource