Yasuhiko Hattori
Okayama University
GeneRadiologyGermline mutationPathologyCellGene expressionImmunohistochemistryIn vivoAneurysmTumor microenvironmentGlioblastomaBevacizumabGliomaStentMacrophageAngiogenesisCysteine rich proteinPoor prognosisAnnexin A2Cancer researchText miningMedicineFibroblast growth factorCell cultureBiology
22Publications
5H-index
54Citations
Publications 23
Newest
#1Yasuhiko HattoriH-Index: 5
Last. Yosuke ShimazuH-Index: 6
view all 13 authors...
Source
#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
2 CitationsSource
#1Satoru Yabuno (Okayama University)H-Index: 2
#2Satoshi Kawauchi (Okayama University)H-Index: 3
Last. Shohei KohnoH-Index: 15
view all 0 authors...
Source
#1Hideyuki Arita (Osaka University)H-Index: 17
#2Yuko MatsushitaH-Index: 14
Last. Koichi IchimuraH-Index: 19
view all 51 authors...
TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information and molecular status data were collected for a cohort of 560 adult patients with IDH-mutated gliomas. Among these patients, 279 had both TERT promoter m...
4 CitationsSource
#1Motomasa Furuse (Osaka Medical College)H-Index: 14
#2Hiroko Kuwabara (Osaka Medical College)H-Index: 16
Last. Shin-Ichi Miyatake (Osaka Medical College)H-Index: 38
view all 14 authors...
BACKGROUND: The prevalence of programmed death-ligand 1 (PD-L1) and PD-L2 expression on tumor cells and tumor-infiltrating immune cells in primary central nervous system lymphoma (PCNSL) remains unclear. In the present study, we analyzed needle biopsy and craniotomy specimens of patients with PCNSL to compare the PD-L1 and PD-L2 levels in the tumor and surrounding (peritumoral) tissue. We also assessed the correlation between biological factors and the prognostic significance of PD-L1 and PD-L2 ...
11 CitationsSource
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 13 authors...
Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of angiogenesis and perivascular invasion. Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clusterin...
4 CitationsSource
#1Yasuyuki Miyoshi (Kawasaki Medical School)
#2Takao Yasuhara (Okayama University)H-Index: 34
Last. Yasuhiko Hattori (Okayama University)H-Index: 5
view all 4 authors...
Source
#1Hideyuki AritaH-Index: 17
#1Hideyuki Arita (National Cancer Research Institute)H-Index: 1
Last. Koichi IchimuraH-Index: 58
view all 33 authors...
Source
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu IchikawaH-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
Source
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Kentaro Fujii (Okayama University)H-Index: 8
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
INTRODUCTION Expression of the gene encoding reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) was reported to be reduced in a variety of human cancer cells. We previously examined the antitumor effect of an adenoviral vector carrying REIC/Dkk-3 gene (Ad-CAG-REIC). Recently, a novel adenoviral vector expressing REIC/Dkk-3 has also been developed based on the cytomegalovirus promoter-driven super gene expression system (Ad-SGE-REIC). We evaluated the anti-glioma effect of the Ad-SG...
Source