John P. Petrali
United States Department of the Army
SurgeryPathologyMolecular biologyChemistryIn vitroCorneaHuman skinGuinea pigHairlessSulfur mustardEdemaToxicityLamina lucidaEpitheliumBiochemistryMedicineBiologyUltrastructureCell biologyPharmacology
Publications 42
#1Devon AndresH-Index: 5
#2Brian KeyserH-Index: 15
Last. Radharaman RayH-Index: 19
view all 7 authors...
Background: Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell lines attractive as in vitro cell models to study neuronal functions and neurotoxicity. The clonal human neuroblastoma BE(2)-M17 cell line is known to differentiate into a more prominent neuronal cell type by treatment with trans-retinoic acid. However, there is a lack of information on the mo...
#1April Deng (UMB: University of Maryland, Baltimore)H-Index: 23
#2D. Bilu Martin (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Grace F. KaoH-Index: 12
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Background: Nephrogenic fibrosing dermopathy (NFD) has emerged as a clinicopathologic entity since 1997 and recently renamed as nephrogenic systemic fibrosis (NSF). The etiology and pathogenesis remain uncertain. Characteristic clinical presentation is described as diffuse thickening and hardening of the skin occurring in patients with renal insufficiency. Typical histological features include proliferation of CD34 positive fibrocytes, increased thick collagen bundles and mucin deposition, witho...
#1Patrick HaydenH-Index: 20
#2John P. Petrali (DA: United States Department of the Army)H-Index: 17
Last. Mitchell KlausnerH-Index: 15
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Abstract Bis-(β-chloroethyl) sulfide (SM) is a potent skin vesicant previously used for chemical warfare. Progress in determination of the mechanistic basis of SM pathology, and development of prophylactic and/or therapeutic countermeasures to SM exposure has been hampered by lack of physiologically relevant models of human skin. The current work evaluated a newly developed tissue engineered full-thickness human skin model in a completely in vitro approach to investigation of SM-induced dermal p...
#1April Deng (UMB: University of Maryland, Baltimore)H-Index: 23
#2Wendy LeeH-Index: 1
Last. John P. PetraliH-Index: 17
view all 8 authors...
An 88-year-old white male presented with a rapidly growing skin nodule on the scalp. Clinically, the nodule did not appear unusual for an ordinary cutaneous neoplasm on sun-exposed skin of an elderly white male. Histopathological examination showed sheet-like epithelioid tumor cell growth with a vaguely nested pattern and frank malignant features, resembling malignant melanoma. However, the tumor cells possessed irregularly convoluted nuclei with nuclear groves, frequent multinucleation and fine...
#1Yuming Zhao (PRC: China Medical University (PRC))H-Index: 6
#2Rita Fishelevich (UMB: University of Maryland, Baltimore)H-Index: 14
Last. Anthony A. Gaspari (UMB: University of Maryland, Baltimore)H-Index: 34
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PKCζ (protein kinase C-ζ), a member of protein kinase C family, plays an important role in cell proliferation, differentiation, and apoptosis. It acts as a downstream molecule for TNF-α (tumor necrosis factor) signal transduction and also regulates the expression of CD1d, an HLA-class I-like molecule. The interaction of CD1d with natural killer T (NKT) cells has been shown to be important in their Th1 cytokine production in psoriasis. In this study, we examined PKCζ in psoriasis in order to defi...
#1Marianne E. Dawn (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
#2April Deng (United States Army Medical Research Institute of Chemical Defense)H-Index: 23
Last. Anthony A. Gaspari (United States Army Medical Research Institute of Chemical Defense)H-Index: 34
view all 6 authors...
A 41-year-old woman presented to our dermatology clinic in February 2005 with a chief complaint of numerous flesh-colored nodules on her back and abdomen. She initially noticed the lesions at age 17 years. The plaques had increased in size and number over time, but remained asymptomatic. The patient reported multiple similar lesions on a maternal uncle and a cousin. Her family history was also notable for cardiomyopathy, resulting in the death of her mother. The patient's past medical history wa...
#2John P. PetraliH-Index: 17
Abstract : Continuing efforts to develop a fieldable noninvasive immunodiagnostic strategy confirmatory for sulfur mustard (HD) skin exposure have led to exploring the potential of stratum corneum tape-stripping to eventually visualize HD-induced keratin adducts on the tape before the onset of the vesication phase of HD pathology. In preliminary experiments summarized here, selected tapes with adhered stripped cells were tested in laboratory-based study for nonspecific staining fidelity, cellula...
#1April DengH-Index: 23
#2John P. PetraliH-Index: 17
Last. Anthony A. GaspariH-Index: 34
view all 5 authors...
Abstract:Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such as plexiform, cellular, epithelioid, and ancient schwannomas. Glandular sch
#1Radharaman RayH-Index: 19
#2K. R. BhatH-Index: 2
Last. William J. SmithH-Index: 20
view all 10 authors...
Abstract : DNA is a major cellular target of the vesicant chemical warfare agent sulfur mustard (SM, bis-(2-chloroethyl) sulfide). Others and we have proposed a possible role of apoptosis in SM vesication. Our results suggest that in SM-exposed human epidermal keratinicytes (HEK), DNA damage, DNA repair, and apoptosis may be interdependent. In HEK, SM causes cell death accompanied by caspase-3 activation indicating apoptosis. The general caspase inhibitor A-VAD-FMK (benzyl oxycarbonly-Val-Ala (o...
#1Robert K. KanH-Index: 12
#2Christina M. PlevaH-Index: 3
Last. John P. Petrali (DA: United States Department of the Army)H-Index: 17
view all 4 authors...
The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections. Brain sections, microwave pretreated in boiling sodium citrate, citric acid, Tris hydrochloride, and EDTA buffers of pH 4, 6, and 8, were labeled with four different clones of MAP-2 monoclonal antibodies. No MAP-2 immunoreactivity was observed in control sections pr...
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