Stéphanie Dudonné
Laval University
EndocrinologyBioavailabilityChemistryAkkermansia muciniphilaOxidative stressType 2 diabetesInsulin resistanceAntioxidantFlavonolsDiet-induced obeseLowbush blueberryCognitive declineFood scienceObesityGut floraBiochemistryPolyphenolMedicineProanthocyanidinBiology
Publications 29
Some polyphenols have been reported to modulate the expression of several genes related to lipid metabolism and insulin signaling, ameliorating metabolic disorders. We investigated the potential for the polyphenols of two varieties of grumixama, the purple fruit rich in anthocyanins and the yellow fruit, both also rich in ellagitannins, to attenuate obesity-associated metabolic disorders. Mice were fed a high fat and high sucrose diet, supplemented daily with yellow and purple extracts (200 mg p...
#1Asma Babar (Laval University)H-Index: 2
#2Lynne Moore (Laval University)H-Index: 41
Last. Sylvie Dodin (Laval University)H-Index: 29
view all 9 authors...
PURPOSE Our objective was to assess the efficacy of a high dose cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection. MATERIAL AND METHODS We recruited 145 healthy, adult women with a history of recurrent urinary tract infection, defined as ≥ 2 in the past 6 months or ≥ 3 in the past 12 months in this randomized, controlled, double-blind clinical trial. Participants were randomized to receive a high dose of standardized, commercially available cranberry proa...
#1Maria-Carolina Rodríguez-Daza (Laval University)H-Index: 1
#1Maria-Carolina Rodríguez-Daza (Laval University)H-Index: 2
Last. Yves Desjardins (Laval University)H-Index: 33
view all 8 authors...
Berries are rich in polyphenols and plant cell wall polysaccharides (fibers), including cellulose, hemicellulose, arabinans and arabino-xyloglucans rich pectin. Most of polyphenols and fibers are known to be poorly absorbed in the small intestine and reach the colon where they interact with the gut microbiota, conferring health benefits to the host. This study assessed the contribution of polyphenol-rich whole cranberry and blueberry fruit powders (CP and BP), and that of their fibrous fractions...
7 CitationsSource
#1Marie-Claude Denis (UdeM: Université de Montréal)H-Index: 1
#2Pascal Dubé (Laval University)H-Index: 10
Last. Alexandra Furtos (UdeM: Université de Montréal)H-Index: 14
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Increasing evidence indicates that fruits contain functional bio-active compounds that have several preventive and therapeutic health benefits. Our group has recently conducted studies to assess th...
#1Arianne Morissette (Laval University)H-Index: 1
#2Camille Kropp (Laval University)H-Index: 2
Last. André Marette (Laval University)H-Index: 61
view all 17 authors...
Blueberry consumption can prevent obesity-linked metabolic diseases and it has been proposed that its polyphenol content may contribute to these effects. Polyphenols have been shown to favourably impact metabolic health, but the role of specific polyphenol classes, and whether the gut microbiota is linked to these effects remains unclear. We aimed to evaluate the impact of whole blueberry and blueberry polyphenols against the development of obesity and insulin resistance, and to determine the po...
12 CitationsSource
#1Maria-Carolina Rodríguez-Daza (Laval University)H-Index: 2
#2Laurence Daoust (Laval University)H-Index: 1
Last. Yves Desjardins (Laval University)H-Index: 33
view all 10 authors...
Blueberries are a rich source of polyphenols, widely studied for the prevention or attenuation of metabolic diseases. However, the health contribution and mechanisms of action of polyphenols depend on their type and structure. Here, we evaluated the effects of a wild blueberry polyphenolic extract (WBE) (Vaccinium angustifolium Aiton) on cardiometabolic parameters, gut microbiota composition and gut epithelium histology of high-fat high-sucrose (HFHS) diet-induced obese mice and determined which...
18 CitationsSource
#1Julien Bensalem (INRA: Institut national de la recherche agronomique)H-Index: 6
#2Stéphanie Dudonné (Laval University)H-Index: 17
Last. Véronique PalletH-Index: 23
view all 14 authors...
: Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. This study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate...
24 CitationsSource
#1Fernando F. Anhê (Laval University)H-Index: 15
#2Renato Tadeu Nachbar (Laval University)H-Index: 14
Last. André MaretteH-Index: 61
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Objective The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential. Design By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal microbial transplantation (FMT), we have assessed the effect of a crude extract of camu camu (CC) on obesi...
78 CitationsSource
#1Julien Bensalem (University of Bordeaux)H-Index: 6
#2Stéphanie Dudonné (Laval University)H-Index: 17
Last. Véronique PalletH-Index: 23
view all 9 authors...
: Ageing is characterised by memory deficits, associated with brain plasticity impairment. Polyphenols from berries, such as flavan-3-ols, anthocyanins, and resveratrol, have been suggested to modulate synaptic plasticity and cognitive processes. In the present study we assessed the preventive effect of a polyphenol-rich extract from grape and blueberry (PEGB), with high concentrations of flavonoids, on age-related cognitive decline in mice. Adult and aged (6 weeks and 16 months) mice were fed a...
30 CitationsSource
#1Fernando F. Anhê (Laval University)H-Index: 15
#2Thibault V. Varin (Laval University)H-Index: 13
Last. André Marette (Laval University)H-Index: 61
view all 15 authors...
Aims/hypothesis There is growing evidence that fruit polyphenols exert beneficial effects on the metabolic syndrome, but the underlying mechanisms remain poorly understood. In the present study, we aimed to analyse the effects of polyphenolic extracts from five types of Arctic berries in a model of diet-induced obesity.
36 CitationsSource