Benjamin Ian Perry
National Health Service
PsychiatryInternal medicineMental healthEthnic groupPsychologyYoung adultInflammationInsulin resistanceLongitudinal studyDepression (differential diagnoses)ComorbidityMental Health ActPsychosisBody mass indexPopulationCardiometabolic riskDiabetes mellitusClinical psychologyMedicineSchizophrenia
57Publications
11H-index
429Citations
Publications 46
Newest
#1Benjamin Ian Perry (University of Cambridge)H-Index: 11
#2Emanuele F. Osimo (University of Cambridge)H-Index: 8
Last. Gulam Khandaker (University of Cambridge)H-Index: 35
view all 3 authors...
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#1Benjamin Ian Perry (University of Cambridge)H-Index: 11
#2Rachel UpthegroveH-Index: 23
Last. Gulam Khandaker (Avon and Wiltshire Mental Health Partnership NHS Trust)H-Index: 35
view all 6 authors...
Abstract null null Background null Schizophrenia, bipolar disorder and depression are associated with inflammation. However, it is unclear whether associations of immunological proteins/traits with these disorders are likely to be causal, or could be explained by reverse causality/residual confounding. null null null Methods null We used bi-directional two-sample Mendelian randomization (MR) and multi-variable MR (MVMR) analysis to examine evidence of causality, specificity and direction of asso...
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#1Benjamin Ian Perry (University of Cambridge)H-Index: 11
#2Emanuele F. Osimo (University of Cambridge)H-Index: 8
Last. Gulam Khandaker (University of Cambridge)H-Index: 35
view all 11 authors...
BACKGROUND Young people with psychosis are at high risk of developing cardiometabolic disorders; however, there is no suitable cardiometabolic risk prediction algorithm for this group. We aimed to develop and externally validate a cardiometabolic risk prediction algorithm for young people with psychosis. METHODS We developed the Psychosis Metabolic Risk Calculator (PsyMetRiC) to predict up to 6-year risk of incident metabolic syndrome in young people (aged 16-35 years) with psychosis from common...
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#1Emanuele F. Osimo (University of Cambridge)H-Index: 8
#2Luke James Baxter (Barking, Havering and Redbridge University Hospitals NHS Trust)H-Index: 1
Last. Gulam Khandaker (UoB: University of Bristol)H-Index: 35
view all 10 authors...
Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublish...
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#1Mohapradeep MohanH-Index: 8
#2Benjamin Ian PerryH-Index: 11
Last. Swaran P. SinghH-Index: 60
view all 4 authors...
As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, indepen...
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#1Yuichiro Akao (Takeda Pharmaceutical Company)H-Index: 1
#2Stacie S. Canan (Celgene)H-Index: 5
Last. Charles E. Mowbray (Geneva College)H-Index: 18
view all 24 authors...
An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. In silico probing of five proprietary pharmaceutical company libraries enabled rapid expansion of the hit chemotype, alleviating initial concerns about the core chemical structure while simultaneously improving antiparasitic activity and selectivity index relative to the background cell line. Subsequent hit optimization...
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#1Benjamin Ian Perry (University of Cambridge)H-Index: 11
#2Stephen Burgess (University of Cambridge)H-Index: 81
Last. Gulam Khandaker (University of Cambridge)H-Index: 35
view all 11 authors...
BACKGROUND Insulin resistance predisposes to cardiometabolic disorders, which are commonly comorbid with schizophrenia and are key contributors to the significant excess mortality in schizophrenia. Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. We aimed to examine whether there is genetic evidence that insulin resistance and 7 related cardiometabolic traits may be causally assoc...
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#1Benjamin Ian Perry (University of Cambridge)H-Index: 11
#2Stanley Zammit (UoB: University of Bristol)H-Index: 73
Last. Gulam Khandaker (University of Cambridge)H-Index: 35
view all 4 authors...
Abstract Background Cross-sectional studies have reported elevated concentrations of inflammatory markers in psychosis and depression. However, questions regarding temporality and specificity of association, crucial for understanding the potential role of inflammation, remain. Methods Based on 2224 ALSPAC birth cohort participants, we used regression analyses to test associations of interleukin-6 (IL-6) and C-reactive protein (CRP) levels at age 9 with risks for psychosis (psychotic experiences;...
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#1Diego Galan (University of Cambridge)
#2Benjamin Ian Perry (University of Cambridge)H-Index: 11
Last. Graham K. Murray (University of Cambridge)H-Index: 46
view all 6 authors...
Abstract Smoking, inflammation and depression commonly co-occur and may be mechanistically linked. However, key questions remain around the direction of association and the influence of residual confounding. We aimed to characterize the association between lifetime smoking and depression, as well as to assess the role that genetically-predicted C-reactive protein (CRP) level, an archetypal inflammatory marker, as a potential mediator for this association. We performed inverse variance weighted M...
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