Boureima Guindo
University of the Sciences
Internal medicineCross-sectional studyCase-control studyDemographyHealth careTranscriptomeCohen's kappaRate ratioTropical medicinePrevalencePediatricsMedical recordImmunologyClinical endpointIn vivoParasitemiaAsymptomaticMalariaAnemiaPlasmodium falciparumArtemether/lumefantrineIndoor residual sprayingMalaria vaccineVerbal autopsyMild feverPopulationCerebral MalariaCirculation timeWorld healthAsymptomatic malariaCarriageTranscription (biology)Incidence (epidemiology)Child mortalityPolymerase chain reactionMedicineParasite hostingCohortBiologyGametocyteEnvironmental health
Publications 6
#1Richard Thomson-Luque (University Hospital Heidelberg)H-Index: 9
#2Lasse Votborg-Novél (MPG: Max Planck Society)H-Index: 1
Last. Boureima Guindo (University of the Sciences)H-Index: 2
view all 22 authors...
Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum's tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental c...
Many African countries have reported declines in malaria incidence, attributed to the implementation of control strategies. In Mali, artemisinin-based combination therapy (ACT) was introduced in 2004, and long-lasting insecticide-treated nets (LLINs) have been partially distributed free of charge since 2007. In the Malian town of Bandiagara, a study conducted from 2009 to 2013 showed a stable incidence of malaria compared with 1999, despite the implementation of ACTs and LLINs. Since 2016, seaso...
#1Modibo Diarra (University of the Sciences)H-Index: 4
#2Drissa Coulibaly (University of the Sciences)H-Index: 26
Last. Issaka Sagara (University of the Sciences)H-Index: 12
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In Mali, since 2007, artemether-lumefantrine has been the first choice against uncomplicated malaria. Despite its effectiveness, a rapid selection of markers of resistance to partner drugs has been documented. This work evaluated the treatment according to the World Health Organization’s standard 28-day treatment method. The primary endpoint was the clinical and parasitological response corrected by a polymerase chain reaction. It was more than 99.9 percent, the proportion of patients with anemi...
#1Karim Traore (University of the Sciences)H-Index: 16
#2Drissy Coulibaly (University of the Sciences)
Last. Mahamadou A. Thera (University of the Sciences)H-Index: 36
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Background Malaria remains a leading cause of child mortality in sub-Saharan Africa. Severe malaria is the main pathway to death caused by malaria. A study of factors associated with protection against severe malaria is best achieved using a case-control design. However, these studies are affected by the quality and appropriateness of the choice of controls that may introduce important bias in study design and definitively alter the conclusions from the studies. It is of paramount importance tha...
#1Drissa Coulibaly (University of Bamako)H-Index: 26
#2Mark A Travassos (University of Bamako)H-Index: 1
Last. Jean Gaudart (AMU: Aix-Marseille University)H-Index: 35
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These authors contributed equally to this work. Abstract. In areas of seasonal malaria transmission, the incidence rate of malaria infection is presumed to be near zero at the end of the dry season. Asymptomatic individuals may constitute a major parasite reservoir during this time. We conducted a longitudinal analysis of the spatio-temporal distribution of clinical malaria and asymptomatic parasitemia over time in a Malian town to highlight these malaria transmission dynamics. For a cohort of 3...
#1Drissa Coulibaly (University of the Sciences)H-Index: 26
#2Mark A. Travassos (UMB: University of Maryland, Baltimore)H-Index: 12
Last. Mahamadou A. Thera (University of the Sciences)H-Index: 36
view all 20 authors...
Background The recent decline in malaria incidence in many African countries has been attributed to the provision of prompt and effective anti-malarial treatment using artemisinin-based combination therapy (ACT) and to the widespread distribution of long-lasting, insecticide-treated bed nets (LLINs). At a malaria vaccine-testing site in Bandiagara, Mali, ACT was introduced in 2004, and LLINs have been distributed free of charge since 2007 to infants after they complete the Expanded Programme of ...
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