Yilin Mao
Curtin University
Internal medicineEndocrinologyNeural stem cellPathologyNeuroscienceSystemic administrationOxidative stressGlial scarNestinSpinal cord injuryAxonMicrogliaConnexinGlial fibrillary acidic proteinSpinal cordTraumatic brain injuryLesionPeptide mimeticAnesthesiaCentral nervous systemMedicinePharmacology
12Publications
7H-index
126Citations
Publications 12
Newest
#1Chidozie C. Anyaegbu (Curtin University)H-Index: 5
#2Yilin Mao (Curtin University)H-Index: 7
Last. Melinda Fitzgerald (Curtin University)H-Index: 28
view all 9 authors...
BACKGROUND Cellular responses at the sub-acute phase of mild traumatic brain injury (mTBI), and their contribution to ongoing damage, are unclear, complex and require simultaneous assessment of multiple cells to elucidate. NEW METHOD An 11-colour flow cytometry method for analysing brain cells was evaluated in a weight-drop rat model of repeated mTBI. Animals received sham, one, two or three mTBI delivered at 24 hr intervals (n = 6/group). Cerebrum homogenates were prepared 11 days after first m...
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#1Yilin Mao (Curtin University)H-Index: 7
#2Anna M. B. Black (UWA: University of Western Australia)H-Index: 3
Last. Melinda Fitzgerald (UWA: University of Western Australia)H-Index: 28
view all 10 authors...
Following mild traumatic brain injury (mTBI), the ionic homeostasis of the central nervous system (CNS) becomes imbalanced. Excess Ca2+ influx into cells triggers molecular cascades, which result in detrimental effects. The authors assessed the effects of a combination of ion channel inhibitors (ICI) following repeated mTBI (rmTBI). Adult female rats were subjected to two rmTBI weight-drop injuries 24 h apart, sham procedures (sham), or no procedures (normal). Lomerizine, which inhibits voltage-...
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#1Hui Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 245
#2Yik Lung Chan (UTS: University of Technology, Sydney)H-Index: 16
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 12 authors...
There is a need for pharmaceutical agents that can reduce neuronal loss and improve functional deficits following traumatic brain injury (TBI). Previous research suggests that oxidative stress and mitochondrial dysfunction play a major role in neuronal damage after TBI. Therefore, this study aimed to investigate two drugs known to have antioxidant effects, L-carnitine and exendin-4, in rats with moderate contusive TBI. L-carnitine (1.5 mM in drinking water) or exendin-4 (15 µg/kg/day, ip) were g...
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#1Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
#2Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 4 authors...
Traumatic spinal cord injury (SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI ( n = 9), sham...
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#1Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
#2Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 10 authors...
Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of Peptide5 systemic administration. Rats were subjected to a mild contusion SCI using the New York University impactor. One cohort was injected intraperitoneally with a single dose of fluorescently labelled Peptide5 and euthanised at 2 or 4 h pos...
Source
#1Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
#2Ryan S. Tonkin (UNSW: University of New South Wales)H-Index: 7
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 8 authors...
Abstract Blocking of Connexin43 hemichannels, the main gap junction protein located on astrocytes in the central nervous system, has been shown to reduce neural injury in a number of models. We demonstrated previously that local administration of a Connexin43 mimetic peptide, Peptide5, reduces secondary tissue damage after spinal cord injury (SCI). Here, we investigated whether acute systemic delivery of Peptide5 is also protective in a model of SCI. Rats were subjected to a mild spinal cord con...
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#1Theresa Sutherland (UTS: University of Technology, Sydney)H-Index: 2
#2Kathryn J. Mathews (USYD: University of Sydney)H-Index: 4
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 5 authors...
There exists a trend for a better functional recovery from spinal cord injury (SCI) in younger patients compared to adults, which is also reported for animal studies; however, the reasons for this are yet to be elucidated. The post injury tissue microenvironment is a complex milieu of cells and signals that interact on multiple levels. Inflammation has been shown to play a significant role in this post injury microenvironment. Endogenous neural progenitor cells (NPC), in the ependymal layer of t...
Source
#1Hui Chen (UTS: University of Technology, Sydney)H-Index: 245
#2Yik Lung Chan (UTS: University of Technology, Sydney)H-Index: 16
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 10 authors...
Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide. Mild TBI may lead to neuropsychiatric sequelae, including memory loss and motor impairment. Mitochondrial dysfunction and oxidative stress have a contributory role in several neurological disorders; however, their association with mitophagy in mild TBI is unclear. TBI was induced in female Sprague Dawley (SD) rats using a New York University Impactor (10g, impactor head 2.5mm diameter, weight drop 5...
Source
#1Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
#2Tara Nguyen (UTS: University of Technology, Sydney)H-Index: 8
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 4 authors...
Stem cell treatments, and in particular, stem cell transplants have been identified as potential therapeutic strategies for a range of neurodegenerative and acquired conditions of the central nervous system (CNS). Stem cell transplants are seen as a way of replacing lost neurons, or providing a cellular environment that is more permissible for axon and cell regeneration. An alternate strategy to transplantation of exogenous stem cells is the recruitment and manipulation of endogenous neural prog...
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#1Yilin Mao (UTS: University of Technology, Sydney)H-Index: 7
#2Kathryn J. Mathews (UTS: University of Technology, Sydney)H-Index: 4
Last. Catherine A. Gorrie (UTS: University of Technology, Sydney)H-Index: 16
view all 3 authors...
A pool of endogenous neural progenitor cells found in the ependymal layer and the sub-ependymal area of the spinal cord are reported to upregulate nestin in response to traumatic spinal cord injury. These cells could potentially be manipulated within a critical time period offering one innovative approach to the repair of spinal cord injury. However, little is known about the temporal response of endogenous neural progenitor cells following spinal cord injury. This study used a mild contusion in...
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