Xu Yan
Shenyang Pharmaceutical University
NephrotoxicityChemistryMetabolic pathwayRadixIn vivoMetabolomicsCyclophosphamideMylabrisUrinePolyamineToxicityCancer markerGradient elutionHplc esi msPlasma samplesKetone bodiesChromatographyLiquid chromatography–mass spectrometryPharmacology
Publications 2
#1Xu Yan (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Knoxiae Radix (HDJ, usually used after being processed into CHDJ) is a traditional Chinese herbal medicine that has been recorded in the Chinese Pharmacopoeia for years. It is said that Glycyrrhizae Radix et Rhizoma (GC) is incompatible with HDJ, but few studies can prove this. In this work, non-targeted metabolomics experiments were performed on rats to evaluate the effect of the combination of the two herbals. For this, we conducted a 28-day administration in rats. The plasma, urine and kidney...
#1Qian Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Yixiang Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Qing Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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A simple and sensitive method for the simultaneous determination of plasma concentrations of five polyamines in normal and Hepatoma-22 mice, and mice treated with Mylabris and Acanthopanax senticosus was developed by HPLC-ESI-MS. Male Kunming mice were divided into nine groups, a control group (inoculation without treatment), a positive group (Cyclophosphamide), treatment groups [Mylabris (4, 8, 16 mg/kg), Acanthopanax senticosus (6, 12, 24 g/kg)] and a normal group (without inoculation). Twenty...
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