Guangyuan Zhao
Northwestern University
CancerBiophysicsMitochondrial permeability transition poreGene knockdownMembrane potentialChemistryTumor initiationMetastasisOvarian cancerDemethylaseStem cellMitochondrionRNA methylationCancer researchCancer stem cellBiochemistryRNABiologyCell biologyCancer cell
12Publications
7H-index
194Citations
Publications 11
Newest
#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 11 authors...
High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted f...
2 CitationsSource
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
11 CitationsSource
#1Hao Huang (NU: Northwestern University)H-Index: 31
#1Hao Huang (NU: Northwestern University)H-Index: 25
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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N6-Methyladenosine (m6A) is the most abundant modification of mammalian messenger RNAs (mRNA). RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase with oncogenic properties in leukemia. Here we show that FTO expression is suppressed in ovarian tumors and cancer stem cells (CSC). FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis in vivo, both of which required FTO demethylas...
20 CitationsSource
#1Hao Huang (NU: Northwestern University)H-Index: 31
#1Hao Huang (NU: Northwestern University)H-Index: 25
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 10 authors...
Introduction: N6-Methyladenosine (m6A) is the most abundant internal modification in mammalian messenger RNAs (mRNAs). Although previous studies have showed that RNA methylation is reversible and plays important roles in various cellular processes, such as metabolism, stem cell development, and self-renewal, its functions in cancer remain elusive. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase and was described as an oncogenic factor in leukemia and brain tumors. We hyp...
Source
#1Yaqi Zhang (NU: Northwestern University)
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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Cancer stem cells (CSCs) are a specific population of cancer cells that are responsible for tumor initiation, chemoresistance, and metastasis. Previously, our lab has demonstrated ovarian cancer cells with high aldehyde dehydrogenase (ALDH) activities have multiple stem cell-like characteristics, including self-renewal, high clonogenicity, and chemoresistance. Here we identify that H3K79 methyltransferase DOT1L (disruptor of telomeric silencing-1-like) is a critical factor in self-renewal and tu...
Source
#1Guangyuan Zhao (NU: Northwestern University)H-Index: 7
#2Horacio Cardenas (NU: Northwestern University)H-Index: 18
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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This review highlights recent advances in the understanding of the relevance of altered lipid metabolic pathways contributing to the poor prognosis of high grade serous ovarian cancer, as they relate to cancer metastasis and cancer stemness. Increased lipid uptake regulated by the receptor CD36 and the transport protein FABP4 has been implicated in ovarian cancer metastasis. The symbiotic relationship between ovarian cancer cells and adipocytes was shown to be important for sustaining widespread...
15 CitationsSource
#1Michael Keegan Delaney (NU: Northwestern University)H-Index: 1
#2Viacheslav Malikov (NU: Northwestern University)H-Index: 11
Last. Mojgan H. Naghavi (NU: Northwestern University)H-Index: 22
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Abstract Diaphanous (Dia)-related formins (DRFs) coordinate cytoskeletal remodeling by controlling actin nucleation and microtubule (MT) stabilization to facilitate processes such as cell polarization and migration; yet the full extent of their activities remains unknown. Here, we uncover two discrete roles and functions of DRFs during early human immunodeficiency virus type 1 (HIV-1) infection. Independent of their actin regulatory activities, Dia1 and Dia2 facilitated HIV-1–induced MT stabiliz...
23 CitationsSource
#1Kerry O’Donnelly (Imperial College London)H-Index: 2
#2Guangyuan Zhao (Imperial College London)H-Index: 7
Last. Laura M. C. Barter (Imperial College London)H-Index: 11
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Background Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is a Calvin Cycle enzyme involved in CO2 assimilation. It is thought to be a major cause of photosynthetic inefficiency, suffering from both a slow catalytic rate and lack of specificity due to a competing reaction with oxygen. Revealing and understanding the engineering rules that dictate Rubisco’s activity could have a significant impact on photosynthetic efficiency and crop yield.
Source
#1Jia-Xin Dong (GXNU: Guangxi Normal University)H-Index: 8
#2Guangyuan Zhao (WHU: Wuhan University)H-Index: 7
Last. Yi Liu (WHU: Wuhan University)H-Index: 67
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Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H+ and K+, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling,...
16 CitationsSource
#1Jia-Han Li (WHU: Wuhan University)H-Index: 16
#2Xiaorong Liu (WHU: Wuhan University)H-Index: 12
Last. Yi Liu (WHU: Wuhan University)H-Index: 67
view all 8 authors...
Zinc oxide nanoparticles (ZnO NPs) are increasingly applied in a diverse array of industrial and commercial products. Therefore, it is urgently required to characterize their toxic behavior. ZnO NPs have been reported to induce toxic effects at the levels of the individual organism, tissue, cell and DNA. However, little is known about the potential impacts of ZnO NPs at a subcellular level. In the present work, we investigated the toxicity of ZnO NPs to the isolated rat liver mitochondria. We fo...
54 CitationsSource