Miguel A. González-Gay
University of Cantabria
Internal medicineEndocrinologyGenotypeSurgeryPathologyDermatologyAlleleRheumatologyImmunologyVasculitisGiant cell arteritisArthritisRheumatoid arthritisDiseasePolymyalgia rheumaticaPopulationIn patientMedicineBiologyGastroenterology
768Publications
85H-index
16.6kCitations
Publications 720
Newest
#1Iván Ferraz-Amaro (Hospital Universitario de Canarias)H-Index: 15
#2Alfonso CorralesH-Index: 21
Last. Miguel A. González-GayH-Index: 85
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BACKGROUND Previous studies have shown that risk chart algorithms, such as the Systematic Coronary Risk Assessment (SCORE), often underestimate the actual cardiovascular (CV) risk of patients with rheumatoid arthritis (RA). In contrast, carotid ultrasound was found to be useful to identify RA patients at high CV. In the present study, we aimed to determine if specific disease features influence the CV risk reclassification of RA patients assessed by SCORE risk charts and carotid ultrasound. METH...
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#1Diana Prieto-PeñaH-Index: 5
#2Fernanda GenreH-Index: 19
Last. Raquel López-MejíasH-Index: 24
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BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502,...
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BACKGROUND The incidence of sarcoidosis varies widely worldwide. The aim of this study was to estimate the incidence of sarcoidosis in a population-based cohort from northern Spain. METHODS Patients diagnosed with sarcoidosis at Marques de Valdecilla University Hospital, corresponding to the central Cantabria that encompasses Santander city and the surroundings, between January 1999 and December 2019were assessed. The diagnosis of sarcoidosis was established according to ATS/ERS/WASOG criteria a...
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#1Elio G. Carmona (CSIC: Spanish National Research Council)H-Index: 1
#2Jose A García-Giménez (CSIC: Spanish National Research Council)
Last. Ana Márquez (CSIC: Spanish National Research Council)H-Index: 20
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Objectives Combination of genomic data of different pathologies as a single phenotype has emerged as a useful strategy to identify genetic risk loci shared among immune-mediated diseases. Our study aimed to increase our knowledge of the genetic contribution to Kawasaki disease (kDa) and IgA vasculitis (IgAV) by performing the first comprehensive large-scale analysis on the genetic overlap between both pediatric vasculitis. Methods A total of 1,190 vasculitis patients and 11 302 healthy controls ...
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Last. Iván Ferraz-Amaro (Hospital Universitario de Canarias)H-Index: 15
view all 9 authors...
OBJECTIVE Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that regulates cholesterol metabolism and has been linked to cardiovascular (CV) risk. The purpose of the present study was to examine whether PCSK9 levels are related to abnormalities in the lipid profile and the development of atherosclerosis that occurs in patients with axial SpA (axSpA). METHODS We performed a cross-sectional study that encompassed 545 individuals; 299 patients with axSpA and 246 statin use-...
2 CitationsSource
Last. Miguel A. González-Gay (UC: University of Cantabria)H-Index: 85
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Abstract Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 1...
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#1Andreina Teresa Manfredi (University of Modena and Reggio Emilia)H-Index: 20
#1Manfredi Andreina (University of Modena and Reggio Emilia)H-Index: 1
Last. Sebastiani Marco (University of Modena and Reggio Emilia)H-Index: 1
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INTRODUCTION Interstitial lung disease (ILD) represents one of the most frequent extra-articular manifestations of rheumatoid arthritis (RA) with a deep impact on both quality of life and overall prognosis. A literature search was performed trough some electronic databases, including PubMed, Embase, Scopus, and Web of Science. Areas covered: Many retrospective studies investigated the possible risk factors for RA-ILD, aiming to early identify patients at risk. Among them, male sex, smoking habit...
1 CitationsSource
#2Fernanda GenreH-Index: 19
Last. Miguel A. González-GayH-Index: 85
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The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy...
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#1Belén Atienza-Mateo (UC: University of Cantabria)H-Index: 7
#2Emma BeltránH-Index: 10
Last. Ricardo Blanco (UC: University of Cantabria)H-Index: 59
view all 16 authors...
OBJECTIVES Anti-IL6R tocilizumab (TCZ) therapy has proved to be useful in the treatment of refractory ocular and/or neurological involvement of Behcet's disease (BD). However, TCZ efficacy in other BD manifestations remains unclear. In this study we aimed to assess the efficacy of TCZ in the different clinical phenotypes of BD. METHODS This is a multicentre study of BD patients treated with TCZ, due to refractivity to standard systemic treatment. RESULTS We studied 16 patients (10 men/6 women); ...
Last. Miguel A. González-Gay (UC: University of Cantabria)H-Index: 85
view all 7 authors...
Abstract Background Interstitial lung disease (ILD) is a serious complication that represents the second leading cause of death in patients with rheumatoid arthritis (RA). Treatment of RA-ILD remains controversial. The absence of randomized clinical trials and specific ACR or EULAR therapeutic guidelines makes it difficult to establish solid therapeutic recommendations on this issue. In this scenario, real-world data is especially valuable. Objective To review the literature evidence on the effi...
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