Anuraag Boddupalli
Iowa State University
Polarization (waves)Self-healing hydrogelsFull width at half maximumMatrix metalloproteinaseIrradiationHydrogen bondSurface modificationSubstrate (chemistry)CancerBiophysicsBasic solutionPhenotypeDrug carrierBiomedical engineeringPolarizabilityMicroscopyNanotechnologyBacterial growthCovalent bondRayLiposomeChemistryExtracellular matrixDecellularizationMaterials scienceSurface energyLipophilicityMyofibroblastIonic bondingTumor microenvironmentContact guidanceTraction force microscopyTissue remodelingAzotobacterVascular endothelial growth factorArginineSilanesSwellingSodium hydroxideGelatinMacrophageGrading (tumors)Drug deliveryPolydimethylsiloxaneAlkylWound healingFibroblastMaterial selectionPhytotoxicityGrowth mediumDoxorubicinImplantPseudomonasCollagen fibril organizationSecond Harmonic Generation MicroscopyEarly Cancer DetectionCancer detectionMultimodal imagingHigh content imagingCollagen fiberHost responsePoly l argininePh changesDiagnostic methodsCollagen fibrilAlginate hydrogelFood scienceTractive forceBrewster's angleContractilityChemical engineeringSecretionTissue engineeringFiberLaserBacteriaMedical diagnosisZincBotanyCell growthPorosityNuclear magnetic resonance spectroscopyMyosinSurface finishCancer cellIsoelectric pointMucilage
13Publications
4H-index
62Citations
Publications 13
Newest
#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Dana Akilbekova (Iowa State University)H-Index: 8
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 3 authors...
Abstract Functionalized biomaterials interface with tissue upon implantation. There is a growing need to understand how materials properties influence this interaction so that efficient tissue engineering systems can be developed. In this study, we characterize collagen organization in response to functionalized glass beads implanted in SKH1-E mice. Poly- l -arginine (PLR) was modified with arginine derivatives to create a functionalized surface and was coated on glass beads. Tissue sections wer...
1 CitationsSource
#1Boyce S. Chang (Iowa State University)H-Index: 11
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Martin M. Thuo (Iowa State University)H-Index: 23
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Abstract Paper-based platforms for biological studies have received significant attention given that cellulose is ubiquitous, biocompatible, and can be readily organized into tunable fibrous structures. In the latter form, effect of complexity in surface morphologies (roughness, porosity and fiber organization) on cell-substrate interaction has not been thoroughly explored. We infer that altering the properties of a fibrous material should lead to significant changes in cellular microenvironment...
1 CitationsSource
#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
We fabricated photocrosslinked, environmentally responsive alginate hydrogels for tissue engineering applications. Methacrylated alginate (ALGMA) hydrogels were prepared across a variety and combination of ionic and covalent (chain growth, step growth, and mixed mode) crosslinking strategies to obtain a range of compressive moduli from 9.3 ± 0.2 kPa for the softest ionically crosslinked hydrogels to 22.6 ± 0.3 kPa for the dually crosslinked ionic mixed mode gels. The swelling behavior of the alg...
4 CitationsSource
#1Juan Wang (Iowa State University)H-Index: 5
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Ian C. Schneider (Iowa State University)H-Index: 14
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Introduction The extracellular matrix (ECM) in the tumor microenvironment contains high densities of collagen that are highly aligned, resulting in directional migration called contact guidance that facilitates efficient migration out of the tumor. Cancer cells can remodel the ECM through traction force controlled by myosin contractility or proteolytic activity controlled by matrix metalloproteinase (MMP) activity, leading to either enhanced or diminished contact guidance.
2 CitationsSource
#1Kendall Neuberger (Iowa State University)H-Index: 1
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Liposomal encapsulation of chemotherapeutics improves circulation time and decreases off-target effects through the enhanced permeability and retention (EPR) effect. Improving the efficacy of these drug carriers through surface modification could benefit patients. A library of arginine derivatives was conjugated to liposomes through carbodiimide chemistry. Both unmodified and modified liposomes were loaded with doxorubicin and exposed to Caco-2 colon carcinoma cells to measure the half ...
2 CitationsSource
#1Juan Wang (Iowa State University)H-Index: 5
#2Joseph Koelbl (Iowa State University)H-Index: 2
Last. Ian C. Schneider (Iowa State University)H-Index: 14
view all 6 authors...
Contact guidance or bidirectional migration along aligned fibers modulates many physiological and pathological processes such as wound healing and cancer invasion. Aligned 2D collagen fibrils epitaxially grown on mica substrates replicate many features of contact guidance seen in aligned 3D collagen fiber networks. However, these 2D collagen self-assembled substrates are difficult to image through, do not have known or tunable mechanical properties and cells degrade and mechanically detach colla...
3 CitationsSource
#1Anuraag Boddupalli (Iowa State University)H-Index: 4
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
: The pH of dermal wounds shifts from neutral during the inflammatory phase to slightly basic in the tissue remodeling phase. Stage specific wound treatment can be developed using environmentally responsive alginate hydrogels. The chemistry of these networks dictates swelling behavior. Here, we fabricated alginate hydrogels using chain growth, step growth, and combined mixed mode gelation methods to crosslink methacrylated alginate (ALGMA) and gain control over swelling responses. Methacrylation...
5 CitationsSource
#1Dana Akilbekova (NU: Nazarbayev University)H-Index: 8
#2Anuraag Boddupalli (Iowa State University)H-Index: 4
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Recent studies have demonstrated the beneficial effect of low-power lasers and polarized light on wound healing, inflammation, and the treatment of rheumatologic and neurologic disorders. The overall effect of laser irradiation treatment is still controversial due to the lack of studies on the biochemical mechanisms and the optimal parameters for the incident light that should be chosen for particular applications. Here, we study how NIH/3T3 fibroblasts respond to irradiation with linearly polar...
1 CitationsSource
#1Anuraag BoddupalliH-Index: 4
#1Anuraag Boddupalli (IARI: Indian Agricultural Research Institute)H-Index: 4
#2Rameshwar Tiwari (IARI: Indian Agricultural Research Institute)H-Index: 16
Last. Lata Nain (IARI: Indian Agricultural Research Institute)H-Index: 41
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There is a growing interest in the use of bioinoculants to assist mineral fertilizers in improving crop production and yield. Azotobacter and Pseudomonas are two agriculturally relevant strains of bacteria which have been established as efficient bioinoculants. An experiment involving addition of graded concentrations of zinc oxide (ZnO) nanoparticles was undertaken using log phase cultures of Azotobacter and Pseudomonas. Growth kinetics revealed a clear trend of gradual decrease with Pseudomona...
8 CitationsSource