Maria Teresa Nuzzo
Roma Tre University
Gene silencingGlobinDownregulation and upregulationEndocrinologyNeuroscienceApoptosisNeuroprotectionOxidative stressNeuroglobinResveratrolNeuropathologyHuntington's diseaseHuntingtinProgrammed cell deathSignal transductionProtein kinase BEstrogen receptorBiologyCell biologyCancer cell
Publications 7
#1Manuela Cipolletti (Roma Tre University)H-Index: 8
#2Emiliano Montalesi (Roma Tre University)H-Index: 4
Last. Maria Marino (Roma Tre University)H-Index: 5
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: Neuroglobin (NGB), an antiapoptotic protein upregulated by 17β-estradiol (E2), is part of E2/estrogen receptor α (ERα) pathway pointed to preserve cancer cell survival in presence of microenvironmental stressors including chemotherapeutic drugs. Here, the possibility that resveratrol (Res), an anticancer plant polyphenol, could increase the susceptibility of breast cancer cells to paclitaxel (Pacl) by affecting E2/ERα/NGB pathway has been evaluated. In MCF-7 and T47D (ERα-positive), but not in...
7 CitationsSource
#1Antonella Cardinale (Roma Tre University)H-Index: 5
#2Francesca R. FuscoH-Index: 33
Last. Mariarosa A. B. Melone (TU: Temple University)H-Index: 30
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Neuroglobin (Ngb) is expressed in the central and peripheral nervous system, cerebrospinal fluid, retina, and endocrine tissues where it is involved in binding O2 and other gasotransmitters. Several studies have highlighted its endogenous neuroprotective function. Huntington’s disease (HD), a dominant hereditary disease, is characterized by the gradual loss of neurons in discrete areas of the central nervous system. We analyzed the expression of Ngb in the brain tissue of a mouse model of HD, in...
3 CitationsSource
#1Maria Teresa Nuzzo (Roma Tre University)H-Index: 5
#2Marco Fiocchetti (Roma Tre University)H-Index: 12
Last. Maria Marino (Roma Tre University)H-Index: 43
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Among several mechanisms underlying the well-known trophic and protective effects of 17β-estradiol (E2) in the brain, we recently reported that E2 induces the up-regulation of two anti-apoptotic and neuroprotectant proteins: huntingtin (HTT) and neuroglobin (NGB). Here, we investigate the role of this up-regulation. The obtained results indicate that E2 promotes NGB-HTT association, induces the localization of the complex at the mitochondria, and protects SK-N-BE neuroblastoma cells and murine s...
14 CitationsSource
#1Paolo AscenziH-Index: 57
#2Alessandra di MasiH-Index: 21
Last. Maria MarinoH-Index: 43
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Abstract In 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to myoglobin and to the α- and β-chains of hemoglobin, however it displays a bis-histidyl six-coordinate heme-Fe atom. Therefore, ligand binding to the Ngb metal center is limited from the dissociation of the distal His(E7)64-Fe bond. From its discovery, more than 500 papers on Ngb structure, expression, reactivity, and lo...
46 CitationsSource
#1Maria Teresa NuzzoH-Index: 5
#2Maria MarinoH-Index: 5
Last. Maria MarinoH-Index: 43
view all 2 authors...
Neurodegenerative diseases (NDs) include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits. The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress, programmed cell death or abnormal protein aggregation, trafficking, and/or degradation. In most cases, the end stage neuropathology is characterized by a highly specific distribution of abnorma...
9 CitationsSource
#1Maria Teresa Nuzzo (Roma Tre University)H-Index: 5
#2Marco Fiocchetti (Roma Tre University)H-Index: 12
Last. Maria Marino (Roma Tre University)H-Index: 43
view all 6 authors...
17β-Estradiol (E2) exerts neurotrophic and neuroprotective functions in the brain. Here, E2-induced increased levels of huntingtin (HTT), a protein involved in several crucial neuronal functions is reported. E2 physiological concentrations up-regulate HTT in hippocampus and striatum of rats as well as in human neuroblastoma cells. This effect requires both nuclear and extra-nuclear estrogen receptor (ER)α activities. Intriguingly, HTT silencing completely prevents E2 protective effects against o...
8 CitationsSource
2 CitationsSource
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