Genia F. Burchall
RMIT University
Internal medicineEndocrinologyEtiologyOncologyAntibodyCD38Follicular phaseMultiple myelomaPlasma cellTissue plasminogen activatorFibrinolysisMonoclonal gammopathy of undetermined significanceInsulin resistanceOvulationOral contraceptive pillOvaryHemostasisDiseaseMalignancyPolycystic ovary syndrome (PCOS)Plasminogen activatorAsymmetric dimethylarginineHyperandrogenismBody mass indexMetforminOverweightPlasminogen activator inhibitor-1AnovulationThrombosisEndothelial dysfunctionDaratumumabLifestyle factorsPolycystic ovaryPhysiologyFolliculogenesisDiabetes mellitusBioinformaticsHormoneMedicine
6Publications
4H-index
42Citations
Publications 7
Newest
#1Fahd A. Kuriri (Shaqra University)H-Index: 2
#2Genia F. Burchall (RMIT: RMIT University)H-Index: 4
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
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The immunoglobulin (Ig)–immunoreceptor tyrosine–based inhibitory motif (ITIM) bearing receptors, PECAM-1 and CEACAM1 have been shown net negative regulators of platelet-collagen interactions and hemi-ITAM signalling pathways. null In this study, a double knockout (DKO) mouse null was developed with deleted PECAM-1 and CEACAM1 to study their combined contribution in platelet activation by glycoprotein VI, C-type lectin-like receptor 2 (CLEC-2), protease activated receptor PAR-4, ADP purinergic re...
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#1Fehaid Alanazi (RMIT: RMIT University)H-Index: 2
#2Faith A.A. Kwa (RMIT: RMIT University)H-Index: 7
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 24
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Multiple myeloma (MM), a plasma cell malignancy, is characterized by lesions in multiple bones involving transformed, matured post-follicular B cells. The course of the disease involves an initial development of monoclonal gammopathy of undetermined significance (MGUS), followed by smoldering MM, before the full MM disease emerges. Despite novel therapies, MM remains incurable, managed by combination therapies, including proteasome inhibitors (PIs), immunomodulators (IMiDs) and anti-human CD38 (...
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#1Genia F. Burchall (RMIT: RMIT University)H-Index: 4
#2Dodie S. Pouniotis (RMIT: RMIT University)H-Index: 15
Last. Terrence J. Piva (RMIT: RMIT University)H-Index: 21
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Background The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted to active plasmin at the time of follicular rupture through a decrease in plasminogen activator inhibitor-1 (PAI-1) and an increase in plasminogen activators. Oligo−/anovulation and follicle arrest are key characteristics of PCOS, but studies evaluating fibrinolytic/proteolytic ma...
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#1Genia F. BurchallH-Index: 4
Polycystic ovary syndrome (PCOS), diagnosed based on hyperandrogenism, ovulatory dysfunction and polycystic ovaries, is one of the most common disorders of reproductive aged females affecting up to 18% of women in this age group. The aetiology of PCOS is
#1Genia F. Burchall (RMIT: RMIT University)H-Index: 4
#2Terrence J. Piva (RMIT: RMIT University)H-Index: 21
Last. Helena J. Teede (Monash University, Clayton campus)H-Index: 76
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Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objective To investigate and compare haemostatic impacts of common pharmacological treatments and explore relationships with hormonal and metabolic variables in PCOS. Patients/Methods Th...
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#1Genia F. Burchall (RMIT: RMIT University)H-Index: 4
#2Terrence J. Piva (RMIT: RMIT University)H-Index: 21
Last. Helena J. Teede (Monash University, Clayton campus)H-Index: 76
view all 6 authors...
Polycystic ovarian syndrome (PCOS) affects 12 to 19% of women and has reproductive and metabolic features (endothelial dysfunction, increased diabetes, and cardiovascular risk factors). It also appears to have altered coagulation and fibrinolysis with a prothrombotic state with epidemiological evidence of increased venous thromboembolism. We aimed to comprehensively assess hemostasis in women with PCOS versus control women. In an established case–control cohort of lean, overweight, and obese wom...
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#1Genia F. Burchall (RMIT: RMIT University)H-Index: 4
#2Matthew D. Linden (RMIT: RMIT University)H-Index: 23
Last. Terrence J. Piva (RMIT: RMIT University)H-Index: 21
view all 4 authors...
Polycystic ovarian syndrome (PCOS), diagnosed based on hyperandrogenism, ovulatory dysfunction, and polycystic ovaries, is one of the most common disorders of reproductive-aged females. Etiology includes both genetic and environmental/lifestyle factors contributing to both insulin resistance and hyperandrogenism. Clinically, PCOS has reproductive, psychological, and metabolic features, the latter predisposing to cardiovascular disease (CVD). Hemostatic abnormalities have an association with and ...
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