John W. Kunstman
Yale University
Risk assessmentInternal medicineEndocrinologySurgeryPathologyOncologyExome sequencingRetrospective cohort studyPancreaticoduodenectomyMEDLINEPancreatic fistulaThyroid carcinomaGastric emptyingPerioperativeIncidence (epidemiology)MutationCarcinogenesisBioinformaticsGeneral surgeryMedicineCohortComplicationBiology
49Publications
18H-index
1,657Citations
Publications 51
Newest
#1Victoria A. Marks (Yale University)H-Index: 1
#2Walter R Hsiang (UCSF: University of California, San Francisco)
Last. Kevin M. Schuster (Yale University)H-Index: 24
view all 7 authors...
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#1Lisa Suzanne Brubaker (BCM: Baylor College of Medicine)H-Index: 3
#2Fabio Casciani (University of Verona)H-Index: 3
Last. Chad G. Ball (U of C: University of Calgary)H-Index: 55
view all 26 authors...
Abstract null null Background null Intraperitoneal drain placement decreases morbidity and mortality in patients who develop a clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreaticoduodenectomy (PD). It is unknown whether multiple drains mitigate CR-POPF better than a single drain. We hypothesize that multiple drains decrease the complication burden more than a single drain in cases at greater risk for CR-POPF. null null null Methods null The Fistula Risk Score (FRS...
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#1Ankit ChhodaH-Index: 6
Last. James J. FarrellH-Index: 21
view all 8 authors...
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#1Ankit ChhodaH-Index: 6
Last. James J. FarrellH-Index: 21
view all 9 authors...
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#1Fabio Casciani (UPenn: University of Pennsylvania)H-Index: 3
#2Maxwell T. Trudeau (UPenn: University of Pennsylvania)H-Index: 4
Last. Ronald R. SalemH-Index: 30
view all 55 authors...
Abstract Background The association between intraoperative estimated blood loss and outcomes after pancreatoduodenectomy has, thus far, been rarely explored. Methods In total, 7,706 pancreatoduodenectomies performed at 18 international institutions composing the Pancreas Fistula Study Group were examined (2003–2020). High estimated blood loss (>700 mL) was defined as twice the median. Propensity score matching (1:1 exact-match) was employed to adjust for variables associated with high estimated ...
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#1Yasheen Gao (Yale University)H-Index: 2
#2Melinda Wang (Yale University)H-Index: 4
Last. Fred S. GorelickH-Index: 59
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Dysregulated expression of the secretory protein renalase (RNLS) can promote pancreatic ductal adenocarcinoma (PDAC) growth in animal models. We characterized RNLS expression in premalignant and malignant PDAC tissue and investigated whether plasma RNLS levels corresponded to clinical PDAC characteristics. RNLS immunohistochemistry was used to determine the presence and distribution of RNLS in normal pancreas, chronic pancreatitis, PDAC precursor lesions, and PDAC tissues. Associations between p...
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#1Margaret A. Tempero (UCSF: University of California, San Francisco)H-Index: 59
#2Mokenge P. Malafa (Moffitt Cancer Center)H-Index: 21
Last. Giby V George (National Comprehensive Cancer Network)H-Index: 2
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Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving...
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#1Fabio Casciani (UPenn: University of Pennsylvania)H-Index: 3
#2Maxwell T. Trudeau (UPenn: University of Pennsylvania)H-Index: 4
Last. John W. KunstmanH-Index: 18
view all 55 authors...
Abstract Background Pancreatoduodenectomies at high risk for clinically relevant pancreatic fistula are uncommon, yet intimidating, situations. In such scenarios, the impact of individual surgeon experience on outcomes is poorly understood. Methods The fistula risk score was applied to identify high-risk patients (fistula risk score 7–10) from 7,706 pancreatoduodenectomies performed at 18 international institutions (2003–2020). For each case, surgeon pancreatoduodenectomy career volume and years...
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Last. John W. KunstmanH-Index: 18
view all 9 authors...
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