Blanca Majem
Autonomous University of Barcelona
RNA extractionCancerInternal medicinePathologyOncologymicroRNACellCadherinNon-coding RNACancer biomarkersCarcinomaExtracellular RNAMetastasisDiseaseLiquid biopsyOvarian tumorProstate cancerOvarian cancerTargeted therapyEpigeneticsCancer researchSalivaCarcinogenesisBioinformaticsRNAComputational biologyMedicineBiology
19Publications
13H-index
393Citations
Publications 18
Newest
Cellular starvation is typically a consequence of tissue injury that disrupts the local blood supply but can also occur where cell populations outgrow the local vasculature, as observed in solid tumors. Cells react to nutrient deprivation by adapting their metabolism, or, if starvation is prolonged, it can result in cell death. Cell starvation also triggers adaptive responses, like angiogenesis, that promote tissue reorganization and repair, but other adaptive responses and their mediators are s...
12 CitationsSource
#1Alfonso Parrilla (Autonomous University of Barcelona)H-Index: 3
#2Marta Barber (Autonomous University of Barcelona)H-Index: 2
Last. Anna Santamaria (Autonomous University of Barcelona)H-Index: 12
view all 10 authors...
Identifying novel actionable factors that critically contribute to tumorigenesis is essential in ovarian cancer, an aggressive and disseminative tumor, with limited therapeutic options available. Here we show that Aurora Borealis (BORA), a mitotic protein that plays a key role in activating the master mitotic kinase polo-like kinase 1 (PLK1), has an oncogenic role in ovarian cancer. Gain and loss of function assays on mouse models and ex vivo patient-derived ascites cultures revealed an oncogeni...
4 CitationsSource
Abstract Lung cancer is the main cause of cancer death worldwide. Non-Small Cell Lung Carcinoma (NSCLC) is the most common subtype of lung cancer, and the prognosis of NSCLC patients in advanced stages is still very poor. Given the need for new therapies, the metabolism of NSCLC has been widely studied in the past two decades to identify vulnerabilities that could be translated into novel anti-metabolic therapeutic approaches. A number of studies have highlighted the role of glucose and mitochon...
7 CitationsSource
#1Óscar Rapado-González (University of Santiago de Compostela)H-Index: 10
#2Blanca Majem (Autonomous University of Barcelona)H-Index: 13
view all 11 authors...
Salivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value for colorectal cancer (CRC) detection. Our study aims to characterize salivary miRNAs in order to identify non-invasive markers for CRC diagnosis. The screening of 754 miRNAs was performed in saliva samples from 14 CRC and 10 healthy controls. The differential expressed miRNAs were validated by RT-qPCR in 51 CRC, 19 adenomas and 37 healthy controls. Receiver o...
17 CitationsSource
#1Blanca Majem (Autonomous University of Barcelona)H-Index: 13
#2Alfonso Parrilla (Autonomous University of Barcelona)H-Index: 3
Last. Anna Santamaria (Autonomous University of Barcelona)H-Index: 12
view all 22 authors...
Ovarian cancer is the most lethal gynecological malignancy due to the silent nature on its early onset and the rapid acquisition of drug resistance. Histologically heterogeneous, it includes several subtypes with different mutational landscapes, hampering the development of effective targeted therapies. Non-coding RNAs are emerging as potential new therapeutic targets in cancer. To search for a microRNA signature related to ovarian carcinomas and study its potential as effective targeted therapy...
20 CitationsSource
#1Feng Li (Hunan University)H-Index: 20
#2Karolina Elżbieta Kaczor-Urbanowicz (UCLA: University of California, Los Angeles)H-Index: 8
Last. David T. WongH-Index: 102
view all 17 authors...
BACKGROUND: It was recently discovered that abundant and stable extracellular RNA (exRNA) species exist in bodily fluids. Saliva is an emerging biofluid for biomarker development for noninvasive detection and screening of local and systemic diseases. Use of RNA-Sequencing (RNA-Seq) to profile exRNA is rapidly growing; however, no single preparation and analysis protocol can be used for all biofluids. Specifically, RNA-Seq of saliva is particularly challenging owing to high abundance of bacterial...
12 CitationsSource
#1Óscar Rapado-González (University of Santiago de Compostela)H-Index: 10
#2Blanca Majem (Autonomous University of Barcelona)H-Index: 13
Last. Maria Mercedes Suarez-Cunqueiro (University of Santiago de Compostela)H-Index: 11
view all 8 authors...
The authors would like to thank the Eugenio Rodriguez Pascual Foundation and the Fundacion Dexeus Salud de la Mujer, for supporting the authors’ studies in the field of salivary biomarkers
28 CitationsSource
#1Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
#2Blanca MajemH-Index: 13
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 17 authors...
Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern. Epithelial-to-mesenchymal transition (EMT) has been reported in OC and downregulation of Epithelial cadherin (E-cadherin) is a hallmark of this process. However, findings on the relationship between E-cadherin levels and OC progression, dissemination and aggressiveness are controversial. In this study, the evaluation of E-cadherin expression in...
30 CitationsSource
#1Blanca MajemH-Index: 13
#2Feng Li (UCLA: University of California, Los Angeles)H-Index: 20
Last. David T. Wong (UCLA: University of California, Los Angeles)H-Index: 102
view all 4 authors...
Salivary biomarkers for disease detection, diagnostic and prognostic assessments have become increasingly well established in recent years. Despite salivary transcriptomic analyses have created a new paradigm in the emerging field for non-invasive molecular diagnosis, other types of RNA, especially non-coding RNAs (ncRNAs), have been the main interest in the scientific community, due to their better stability in a cell-free context than mRNAs. In this chapter, we will overview the development of...
7 CitationsSource
#1Óscar Rapado-González (University of Santiago de Compostela)H-Index: 10
#2Blanca Majem (Autonomous University of Barcelona)H-Index: 13
Last. Maria Mercedes Suarez-Cunqueiro (University of Santiago de Compostela)H-Index: 11
view all 5 authors...
The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been proposed as cancer biomarkers for diagnosis, prognosis, drug monitoring and pharmacogenetic studies. In this review, we focus on the current status of the salivary diagnostic biomark...
13 CitationsSource