Marcus E. Peter
Northwestern University
GeneCancermicroRNAMolecular biologyReceptorDeath-inducing signaling complexChemistryApoptosisImmunologyFADDOvarian cancerFas receptorProgrammed cell deathCaspase 8Cancer researchBiochemistrySignal transductionFas ligandBiologyCell biologyCancer cellCaspase
220Publications
92H-index
38.9kCitations
Publications 208
Newest
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women, and development of resistance to platinum remains a major barrier to achieving a cure. Multiple mechanisms have been identified to confer platinum resistance. Numerous microRNAs (miRNAs) have been linked to platinum sensitivity and resistance in ovarian cancer. miRNA activity occurs mainly when the guide strand of the miRNA, with its seed sequence at position 2-7/8, is loaded into the RNA-induced silencing (RIS...
1 CitationsSource
#1Elizabeth T. Bartom (NU: Northwestern University)H-Index: 21
#2Masha Kocherginsky (NU: Northwestern University)H-Index: 39
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
micro(mi)RNAs are (18-22nt long) noncoding short (s)RNAs that suppress gene expression by targeting the 39 untranslated region of target mRNAs. This occurs through the seed sequence located in position 2-7/8 of the miRNA guide strand, once it is loaded into the RNA induced silencing complex (RISC). G-rich 6mer seed sequences can kill cells by targeting C-rich 6mer seed matches located in genes that are critical for cell survival. This results in induction of Death Induced by Survival gene Elimin...
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#1J. P. Guegan (French Institute of Health and Medical Research)H-Index: 1
Last. Patrick LegembreH-Index: 28
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CD95L is expressed by tumor-infiltrating lymphocytes to eliminate CD95-expressing tumor cells and thereby CD95 loss by tumor cells is often considered as a consequence of an immunoediting process. Nonetheless CD95 expression is maintained in most triple negative breast cancers (TNBCs), and we recently reported that CD95 loss in TNBC cells triggers the induction of a pro-inflammatory program promoting the recruitment of cytotoxic NK and CD8+ T-cells and impairing tumor growth. Using a comprehensi...
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#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Numerous micro(mi)RNAs (short noncoding RNAs that negatively regulate gene expression) have been linked to platinum (Pt) sensitivity and resistance in ovarian cancer (OC). miRNA activity occurs when the guide strand of the miRNA, with its seed sequence (pos. 2-7/8), is loaded into the RNA induced silencing complex (RISC) and targets complementary short seed matches in the 39 untranslated region of mRNAs. Toxic seeds, targeting genes critical for cancer cell survival, have been found in tumor sup...
Source
#1A. S. Qadir (French Institute of Health and Medical Research)H-Index: 1
#2J. P. GueganH-Index: 1
Last. Marcus E. PeterH-Index: 92
view all 19 authors...
The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. Stimulation by its cognate ligand CD95L on many cancer cells increases their growth, motility, ability to invade and/or their cancer stemness. Using genetically engineered mouse models of ovarian and liver cancer, we previously reported that deletion of CD95 in the tumor cells strongly reduced their ability to grow in vivo [1, 2]. Using a combination of immune-deficient and immune-competent mouse models, we now establi...
2 CitationsSource
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Ye Wang (NU: Northwestern University)H-Index: 4
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Development of platinum (Pt) resistance is a major barrier to curing ovarian cancer (OC). 6mer seed toxicity is a novel cancer killing mechanism mediated by tumor suppressive miRNAs with a toxic 6mer seed sequence (positions 2-7) through the RNA-induced silencing complex (RISC). The most toxic 6mer seeds are G-rich and kill cells by targeting the 3' untranslated region of genes critical for cell survival. We now show that treatment of OC cells with Pt leads to an increase in RISC-bound miRNAs ca...
1 CitationsSource
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
11 CitationsSource
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Elizabeth T. Bartom (NU: Northwestern University)H-Index: 21
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 7 authors...
6mer seed toxicity is a novel anti-cancer mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si- or shRNAs with a specific G-rich nucleotide composition in position 2-7 of their guide strand. An arrayed screen of 4096 6mer seeds on two human and two mouse cell lines identified a consensus GGGGGC as the most toxic seed. After testing two more cell lines, one human and one mouse, we found that the GGGGGC seed while also toxic to murine...
4 CitationsSource
#1Andrea E. Murmann (NU: Northwestern University)H-Index: 18
#2Elizabeth T. Bartom (NU: Northwestern University)H-Index: 21
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 6 authors...
Summary MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is highly toxic to cells by targeting genes essential for cell survival. A screen of 215 miRNAs encoded by 17 human pathogenic viruses (v-miRNAs) now suggests that a number of v-miRNAs can kill cells throug...
6 CitationsSource
#1Abdul S. Qadir (UIC: University of Illinois at Chicago)H-Index: 10
#2Austin Stults (NU: Northwestern University)H-Index: 4
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 4 authors...
CD95/Fas is an apoptosis inducing death receptor. However, it also has multiple nonapoptotic activities that are tumorigenic. Chronic stimulation of CD95 on breast cancer cells can increase their cancer initiating capacity through activation of a type I interferon (IFN-I)/STAT1 pathway when caspases are inhibited. We now show that this activity relies on the canonical components of the CD95 death-inducing signaling complex, FADD and caspase-8, and on the activation of NF-κB. We identified caspas...
8 CitationsSource