Ju Hyeong Park
Kyung Hee University
Proinflammatory cytokineImmunologyInflammationVascular endothelial growth factorRetinaRetinal pigment epitheliumRegulatory T cellCytokineBone marrowWound healingAngiogenesisIntestinal epitheliumStem cellRetina LayerCytokine secretionDiabetes mellitusCell growthBiologyImmune systemCell biology
4Publications
3H-index
54Citations
Publications 4
Newest
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Dae Yeon Hwang (Kyung Hee University)H-Index: 3
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 6 authors...
Abstract Intestinal inflammation alters immune responses in the mucosa and destroys colon architecture, leading to serious diseases such as inflammatory bowel disease (IBD). Thus, regulation of inflammation is regarded as the ultimate therapy for intestinal disease. Substance-P (SP) is known to mediate proliferation, migration, and cellular senescence in a variety of cells. SP was found to mobilize stem cells from bone marrow to the site of injury and to suppress inflammatory responses by induci...
9 CitationsSource
#1Dae Yeon Hwang (Kyung Hee University)H-Index: 3
#2Ju Hyeong Park (Kyung Hee University)H-Index: 3
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
view all 5 authors...
Dextran sulfate sodium (DSS) has been used to destroy intestinal epithelium structure and impair barrier function to mimic clinic intestine damages, which causes the intestinal inflammation and furthermore, tissue destruction. In this study, we have attempted to damage intestinal epithelium by treating DSS to Caco-2, human intestinal epithelial cell line, and elucidated the recovery effect of SP in vitro. DSS altered cellular morphology with the loss of TJ and reduced cell viability. Notably, DS...
3 CitationsSource
#1Ju Hyeong Park (Kyung Hee University)H-Index: 3
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 4 authors...
Diabetic ulceration is one of the most debilitating complications of diabetes and is the main cause of amputation. The diabetic environment is characterized by prolonged inflammation and abnormal angiogenesis, leading to delayed wound healing. Thus, regulation of inflammation and neovascularization is considered a desirable target for diabetes. The critical purpose of this study was to determine whether systemically administered Substance P (SP) could promote wound healing in diabetic environmen...
33 CitationsSource
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 6 authors...
The retinal pigment epithelium (RPE) is a monolayer to function as a compact barrier between photoreceptor and choroid and also a regulator of the overlying photoreceptor layer by providing nutrients. If RPE is damaged, choroidal neovascularization is occurred, accompanied by inflammation, which leads to degeneration of whole retina layer and furthermore, loss of vision. Thus, the preservation of RPE layer is very critical treatment to block the progression and occurrence of diverse ocular disea...
7 CitationsSource