Wei Yu
Hubei University
Internal medicineEndocrinologyTumor necrosis factor alphaChemistryApoptosisProtein kinase CTUNEL assayAutophagyOxidative stressWestern blotDiabetic cardiomyopathyInflammationCardiotoxicityCurcuminMalondialdehydeApigeninGlutathione peroxidaseStreptozotocinNADPH oxidaseIntraperitoneal injectionSuperoxideLipid peroxidationCerebral cortexHippocampusMorris water navigation taskViability assayDiabetes mellitusMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biologyPharmacology
Publications 5
#1Qing Min (Huda: Hubei University)H-Index: 1
#2Yuting Bai (Huda: Hubei University)H-Index: 1
Last. Wei Lv (Huda: Hubei University)H-Index: 1
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Objectives. DCM has become one of the main reasons of death in diabetic patients. In this study, we aimed to explore the hawthorn leaf flavonoids (HLF) protective effect against diabetes-induced cardiac injury and the underlying mechanisms in experimental rats. Methods. Experimental diabetic model was induced by intraperitoneal injection of streptozotocin (STZ, 40 mg/kg) in rats after feeding with high-fat diet for 8 weeks. The diabetic rats received a 16-week treatment of different doses of HLF...
7 CitationsSource
#1Wei Yu (Huda: Hubei University)H-Index: 5
#2Huirong SunH-Index: 2
Last. Jiliang Wu (Huda: Hubei University)H-Index: 7
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Treatment with Adriamycin (ADR) is one of the major causes of chemotherapy-induced cardiotoxicity and therefore is the principal limiting factor in the effectiveness of chemotherapy for cancer patients. Apigenin (API) has been shown to play a cardioprotective role. The present study examined the effect of API on ADR-induced cardiotoxicity in mice. Sixty male Kunming mice were randomly divided into 4 groups: a control group, ADR model group, low-dose API treatment group (125 mg·kg−1), and high-do...
26 CitationsSource
#1Wei Yu (Huda: Hubei University)H-Index: 5
#2Wenliang Zha (Huda: Hubei University)H-Index: 5
Last. Chao Liu (Huda: Hubei University)H-Index: 9
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The function of curcumin on NADPH oxidase-related ROS production and cardiac apoptosis, together with the modulation of protein signalling pathways, was investigated in cardiomyocytes. Primary cultures of neonatal rat cardiomyocytes were exposed to 30 mmol/L high glucose with or without curcumin. Cell viability, apoptosis, superoxide formation, the expression of NADPH oxidase subunits, and potential regulatory molecules, Akt and GSK-3β, were assessed in cardiomyocytes. Cardiomyocytes exposure to...
42 CitationsSource
Objective. The effects of Flos Puerariae extract (FPE) on cognitive impairment associated with diabetes were assessed in C57BL/6J mice. Methods. Experimental diabetic mice model was induced by one injection of 50 mg/kg streptozotocin (STZ) for 5 days consecutively. FPE was orally administrated at the dosages of 50, 100, or 200 mg/kg/day, respectively. The learning and memory ability was assessed by Morris water maze test. Body weight, blood glucose, free fatty acid (FFA) and total cholesterol (T...
11 CitationsSource
#1Wei Yu (Huda: Hubei University)H-Index: 5
#2Wenliang Zha (Huda: Hubei University)H-Index: 5
Last. Chao Liu (Huda: Hubei University)H-Index: 9
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Background Diabetic cardiomyopathy (DCM) suggests a direct cellular insult to myocardium. Apoptosis is considered as one of the hallmarks of DCM. Oxidative stress plays a key role in the pathogenesis of DCM. In this study, we explored the prevention of myocardial apoptosis by crude extract from Flos Puerariae (FPE) in experimental diabetic mice. Methods Experimental diabetic model was induced by intraperitoneally injection of streptozotocin (STZ, 50 mg/kg/day) for five consecutive days in C57BL/...
24 CitationsSource