Jana Nano
Erasmus University Medical Center
Internal medicineEndocrinologyRenal functionDNA methylationCohort studyRotterdam StudyType 2 diabetesInsulin resistanceKidney diseaseDiseaseInsulinPrediabetesMendelian randomizationBody mass indexPopulationEpigeneticsDiabetes mellitusBioinformaticsHistoneCandidate geneComputational biologyMedicineBiology
Publications 44
#1Jana NanoH-Index: 17
#2Ben Schöttker (Heidelberg University)H-Index: 67
Last. Barbara ThorandH-Index: 88
view all 16 authors...
Background null Inflammatory processes have been implicated in the development of chronic kidney disease (CKD). We investigated the association of a large panel of inflammatory biomarkers reflecting aspects of immunity with kidney function and CKD incidence. null Methods null We used data from two independent population-based studies, KORA F4 (discovery, n = 1,110, mean age 70.3 years, 48.7% male) and ESTHER (replication, n = 1,672, mean age 61.9 years, 43.6% male). Serum levels of biomarkers we...
#9Raha Pazoki (Imperial College London)H-Index: 23
Observational studies suggest that early onset of menopause is associated with increased risk of hypertension. Whether this association is causal or due to residual confounding and/or reverse causation remains undetermined. We aimed to evaluate the observational and causal association between age at natural menopause (ANM) and blood pressure traits in Caucasian women. A cross-sectional and one-sample Mendelian randomization (MR) study was conducted in 4451 postmenopausal women from the CoLaus an...
Objective null It is still controversial if increased hepatic fat independently contributes to cardiovascular risk. We aimed to assess the association between hepatic fat quantified by MRI and various subclinical vascular disease parameters. null Design null We included two cross-sectional investigations embedded in two independent population-based studies (Study of Health in Pomerania (SHIP): n=1341; Cooperative Health Research in the Region of Augsburg (KORA): n=386). The participants underwen...
#2Rory P. WilsonH-Index: 75
Last. Pascal Schlosser (University of Freiburg)H-Index: 7
view all 37 authors...
BACKGROUND Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed. METHODS A cross-sectional study of 993 plasma proteins among 2,882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified trans-et...
#2Cavin K. Ward-Caviness (EPA: United States Environmental Protection Agency)H-Index: 19
Last. Elena Colicino (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 24
view all 40 authors...
BACKGROUND The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morbidity and mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations between seven DNAm aging and lifespan predictors (as well as GrimAge component...
#1Jialing HuangH-Index: 7
#2Marcela CovicH-Index: 3
Last. Rui Wang-SattlerH-Index: 31
view all 20 authors...
Biological exploration of early biomarkers for chronic kidney disease (CKD) in (pre)diabetic individuals is crucial for personalized management of diabetes. Here, we evaluated two candidate biomarkers of incident CKD (sphingomyelin (SM) C18:1 and phosphatidylcholine diacyl (PC aa) C38:0) concerning kidney function in hyperglycemic participants of the Cooperative Health Research in the Region of Augsburg (KORA) cohort, and in two biofluids and six organs of leptin receptor-deficient (db/db) mice ...
INTRODUCTION Relationships between endogenous female sex hormones and glycemic traits remain understudied, especially in men. We examined whether endogenous 17α-hydroxyprogesterone (17-OHP), progesterone, estradiol (E2), and free estradiol (fE2) were associated with glycemic traits and glycemic deterioration. RESEARCH DESIGN AND METHODS 921 mainly middle-aged and elderly men and 390 perimenopausal/postmenopausal women from the German population-based Cooperative Health Research in the Region of ...
#3Masoud Amiri (Erasmus University Medical Center)H-Index: 1
Background Fatty liver disease (FLD), primarily non-alcoholic fatty liver disease (NAFLD), is the most common liver disorder that affects a quarter of the global population. NAFLD is a spectrum of disease ranging from simple steatosis to non-alcoholic steatohepatitis, which is associated with increased risk of developing liver cancer. Given that the pathogenic mechanisms of fatty liver remain largely elusive, it is important to further investigate potential underlying mechanisms including epigen...
#1Jialing HuangH-Index: 7
#2Cornelia HuthH-Index: 38
Last. Rui Wang-SattlerH-Index: 31
view all 20 authors...
Early and precise identification of individuals with pre-diabetes and type 2 diabetes (T2D) at risk of progressing to chronic kidney disease (CKD) is essential to prevent complications of diabetes. Here, we identify and evaluate prospective metabolite biomarkers and the best set of predictors of CKD in the longitudinal, population-based Cooperative Health Research in the Region of Augsburg (KORA) cohort by targeted metabolomics and machine learning approaches. Out of 125 targeted metabolites, sp...
#1Anubha Mahajan (University of Oxford)H-Index: 71
#2Cassandra N. Spracklen (UMass: University of Massachusetts Amherst)H-Index: 19
Last. Young-Jin KimH-Index: 87
view all 246 authors...
We assembled an ancestrally diverse collection of genome-wide association studies of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). We identified 277 loci at genome-wide significance (p 50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying foundations for functional investigations. Trans-ancestry genetic risk scores enha...
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