Dan Su
Shenyang Pharmaceutical University
ExcretionTherapeutic effectAnalyteTriterpenoidCytotoxicityPharmacokineticsDetection limitNephrotoxicityInternal medicineEndocrinologyRenal functionTumor necrosis factor alphaHigh-performance liquid chromatographyStereoselectivityChemistryTraditional Chinese medicineApoptosisDecoctionMorningStructural isomerImmunologyMetabolomicsHyperosideDerivatizationArthritisFormic acidMetaboliteRheumatoid arthritisAspirinAdjuvantApocynum venetumKidney diseaseIpomoeaXanthocerasIntradermal injectionUrineKidneyDauricineCreatinineConvolvulaceaeCarnosineThiolKidney metabolismDoxorubicin HydrochlorideCell cycleToxicityBlood chemistryQuantitative structureEdible oilHealth benefitsLc ms msAnti tumourTandem mass spectrometryToxicologyElectrospray ionizationPhysiologyChromatographyTerpeneEnantiomerTraditional medicineBotanyCell growthLiquid chromatography–mass spectrometrySelected reaction monitoringStereochemistryMedicineElutionHuskUrinary systemCell culturePharmacology
9Publications
7H-index
178Citations
Publications 9
Newest
#1Jia Yu (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Bolin Zhu (SPU: Shenyang Pharmaceutical University)H-Index: 6
Last. Zhen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 9
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A sensitive, specific and rapid ultra-performance liquid chromatography tandem mass spectrometry method (UPLC-MS/MS) was developed for simultaneous determination of three main alkaloids (daucicoline, daurisoline, dauricine) in rat plasma, urine and feces after oral administration of menispermi rhizoma capsules. The chromatographic separation was performed on a Waters ACQUITY UPLC® BEH C18 column (50 mm × 2.1 mm, id, 1.7 μm) with a column temperature of 30 °C and a linear gradient elution using a...
1 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Abstract The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isolated 10 barrigenol triterpenoids, including six new compounds (1–6) and four known compounds (7–10). New compounds 3 and 5 showed significant inhibitory activity against the...
12 CitationsSource
#1Xiaoli Han (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Ethnopharmacological relevance Saussurea involucrate (Kar. et Kir.) Sch. -Bip is an endangered species of the Compositae family, and this species has long been used for the treatment of rheumatoid arthritis, dysmenorrhea, stomachache, and altitude sickness in Uighur folk and Chinese medicine. Aim of the study This study aimed to investigate the different therapeutic efficacy of alcohol infusion (SEI) and water decoction (SWD) of S. involucrata in treating rheumatoid arthritis using comp...
17 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Barrigenol-like triterpenoids containing angeloyl residues in their structures are unusual natural products. To discover the chemical constituents responsible for the antitumor activity of Xanthoceras sorbifolia Bunge, the present study was carried out using the husk of this crop. Ten angeloyl barrigenol triterpenoids, including seven new (1–7) and three known compounds (8–10), were isolated from the active fraction via the bioassay-guided method. The structures of the compounds were established...
16 CitationsSource
#1Chunling Zhou (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yang LiuH-Index: 1
Last. Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
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We report the development and validation of a rapid, specific, and sensitive liquid chromatographic–tandem mass spectrometric (LC–MS–MS) method for analysis and pharmacokinetic study, in rats, of hyperoside and isoquercitrin, two bioactive structural isomers present in the leaves of Apocynum venetum L. After simple deproteinization by addition of acetonitrile, the analytes were separated on a C18 column. Detection was by tandem mass spectrometry in multiple reaction monitoring mode. The method w...
21 CitationsSource
#1Chao Ma (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
Last. Xiaohui Chen (SPU: Shenyang Pharmaceutical University)H-Index: 25
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Abstract This paper was designed to study metabonomic characters of the nephrotoxicity induced by Morning Glory Seed (MGS), a well-known traditional Chinese medicine which was used for the treatment of edema, simple obesity and lung fever. Urinary samples from control and MGS treated rats were analyzed by ultra-performance liquid chromatography/mass spectrometry (UPLC–MS) in positive ionization mode. Blood biochemistry and histopathology were examined to identify specific changes of renal damage...
43 CitationsSource
#1Chao Ma (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Xiaohui Chen (SPU: Shenyang Pharmaceutical University)H-Index: 1
view all 8 authors...
Previous nephrotoxicology study on Morning Glory Seed (MGS) mainly focused on whole animal level, using creatinine and BUN as biochemical indicators to evaluate renal function. This work was designed to delineate the comprehensive metabolic syndromes of MGS-induced nephrotoxicity. An ultra liquid chromatography coupled with mass spectrometry (UPLC/MS) metabonomic approach was employed to characterize the metabolic profile of plasma and kidney tissue extract from rats treated with MGS at a single...
31 CitationsSource
#1Chao Ma (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
Last. Xiaohui Chen (SPU: Shenyang Pharmaceutical University)H-Index: 25
view all 8 authors...
Abstract Ethnopharmacological relevance Morning Glory Seed (MGS) is a valuable traditional Chinese medicine which is widely used for the treatment of edema, ascites, hydroncus, simple obesity, lung fever and ardent fever. In recent years, long-term exposure to Morning Glory Seed (MGS) has shown to pose progressive renal damage in clinical practice. We hypothesize that changes in metabolic profile could have occurred before symptoms were observed, which may allow early treatment. Aim of the study...
37 CitationsSource
#1Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Kaishun Bi (SPU: Shenyang Pharmaceutical University)H-Index: 32
Last. Xiaohui Chen (SPU: Shenyang Pharmaceutical University)H-Index: 25
view all 8 authors...
A sensitive fluorescence liquid chromatographic analytical method was developed for the simultaneous determination of carnosine enantiomers in rat plasma. The method was applied to pharmacokinetic studies. Chiral separation of carnosine enantiomers was achieved by pre-column derivatization with o-phthaldialdehyde and the thiol N-acety-l-cysteine as derivating reagents. They were separated on an ODS column and detected by fluorescence detection (λex = 350 nm, λem = 450 nm). γ-Aminobutyric acid wa...
5 CitationsSource