Diane M. Citron
Michigan State University
Internal medicineSurgeryIn vitroCefoxitinMetronidazoleClindamycinBacteroidesErtapenemVancomycinStaphylococcus aureusBacteroides fragilisFusobacteriumAnaerobic bacteriaClostridium difficileAntibacterial agentAntimicrobialAntibioticsAnaerobic exerciseBacteriaMedicineBiologyMicrobiology
171Publications
57H-index
7,302Citations
Publications 171
Newest
#1C. Vreni MerriamH-Index: 26
#2Diane M. CitronH-Index: 57
Last. Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
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At this time in the USA there are no antimicrobials with specific indications for oral infections, and many of those currently used have limited efficacy against oral anaerobic strains. We tested the activity of azithromycin against a broad range of anaerobic oral pathogens and, at pH 8, found it to be effective against 98% of strains, including all fusobacteria and β-lactamase-producing strains of Prevotella spp. All strains of Eikenella corrodens were also susceptible to azithromycin but resis...
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#1Kerin L. TyrrellH-Index: 27
#2Diane M. CitronH-Index: 57
Last. Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
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Daptomycin has in vitro activity against gram-positive anaerobic bacteria, although limited numbers of species have been tested. We studied the in vitro activities of daptomycin, vancomycin, and penicillin against more than 100 strains each of Clostridium difficile, C. perfringens, Finegoldia magna, and Propionibacterium acnes. Daptomycin Etest MICs and results from time-kill studies were determined for selected strains. For 392 of 421 strains (93%), daptomycin was inhibitory at ≤1 μg/ml, includ...
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#1Hans-Peter Horz (RWTH Aachen University)H-Index: 28
#2Diane M. CitronH-Index: 57
Last. Georg Conrads (RWTH Aachen University)H-Index: 23
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The bacterial division Synergistes represents a poorly characterized phylotype of which only a few isolates have been cultured, primarily from natural environments. Recent detection of Synergistes-like sequence types in periodontal pockets and caries lesions of humans prompted us to search the R. M. Alden culture collection (Santa Monica, Calif.) for biochemically unidentifiable, slow-growing, obligately anaerobic gram-negative bacilli. Here we report on five clinical isolates cultured from peri...
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#1Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
#2Diane M. CitronH-Index: 57
Last. Helen T. FernandezH-Index: 18
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Tests of dalbavancin's in vitro activity against 209 aerobic and 120 anaerobic isolates from pretreatment diabetic foot infections showed an MIC90 of ≤0.125 μg/ml against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), and 120 anaerobes (Clostridium perfringens, other clostridia, Peptoniphilus asaccharolyticus, Finegoldia magna, and Anaerococcus prevotii), compared to respective MIC90s for MSSA and MRSA of 0.5 and 1 μg/ml for vancomycin, 4 and 4 μg/m...
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#1Yumi A. WarrenH-Index: 25
#2Kerin L. TyrrellH-Index: 27
Last. Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
view all 4 authors...
One hundred eight isolates were previously identified in our laboratory as Clostridium clostridioforme by colonial and cellular morphology, as well as biochemical tests. Recent studies have indicated that there are actually three different species in this C. clostridioforme group: C. hathewayi, C. bolteae, and C. clostridioforme. Our isolates were reexamined using biochemical and enzymatic tests and molecular methods. Forty-six isolates were reidentified as C. hathewayi, 34 as C. bolteae, five a...
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#2Diane M. CitronH-Index: 57
Last. Helen T. FernandezH-Index: 18
view all 7 authors...
Abstract The in vitro activity of 11 antimicrobials was tested against 74 recent anaerobic isolates obtained from pretreatment cultures in pediatric patients with complicated intra-abdominal infections using the CLSI M11-A-6 agar dilution method. Carbapenems, β -lactamase inhibitor combinations and metronidazole retained good activity, while all Bacteroides fragilis group species produced β -lactamase and were penicillin resistant and 43% were either intermediately susceptible or resistant to cl...
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: Ochrobactrum intermedium [corrected] infection is rare in humans and is generally associated with immunocompromised hosts with indwelling foreign bodies. We report a case of pelvic abscess with O. intermedium [corrected] after a routine appendectomy in an immunocompetent patient and review the literature on O. intermedium [corrected] infection in patients with normal immune function.
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#1Sagar A. Vaidya (UCLA: University of California, Los Angeles)H-Index: 11
#2Diane M. Citron (UCLA: University of California, Los Angeles)H-Index: 57
Last. Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
view all 5 authors...
Ochrobactrum anthropi infection is rare in humans and is generally associated with immunocompromised hosts with indwelling foreign bodies. We report a case of pelvic abscess with O. anthropi after a routine appendectomy in an immunocompetent patient and review the literature on O. anthropi infection in patients with normal immune function.
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#1M. C. Claros (Leipzig University)H-Index: 15
#2Z.C. Claros (Leipzig University)H-Index: 1
Last. Arne C. Rodloff (Leipzig University)H-Index: 40
view all 8 authors...
Abstract Bacteroides fragilis is an important anaerobic pathogen accounting for up to 10% of bacteremias in adult patients. Enterotoxin producing B. fragilis (ETBF) strains have been identified as enteric pathogens of children and adults. In order to further characterize the B. fragilis pathogenicity island (BfPAI) and using PCR assays for bft- and mpII-metalloprotease genes, we determined the frequency of B. fragilis strains with pattern I (containing the BfPAI and its flanking region), pattern...
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#1Ellie J. C. Goldstein (UCLA: University of California, Los Angeles)H-Index: 66
#2Diane M. CitronH-Index: 57
Last. Helen T. FernandezH-Index: 18
view all 6 authors...
Intra-abdominal infections are known to be composed of mixed aerobic and anaerobic bacteria (9). Current guidelines (22) recommend combining a fluoroquinolone with metronidazole for therapy of community-acquired intra-abdominal infections. Moxifloxacin, an 8-methoxyquinolone, has been reported to have activity against a broad spectrum of both aerobic and anaerobic bacteria (1, 4-6, 10, 14, 15, 25) such as encountered in intra-abdominal infections. However, many older in vitro studies employed a ...
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