Veronica Basso
Vita-Salute San Raffaele University
Interleukin 21AntigenCytotoxic T cellCD8T-cell receptorImmunologyT cellInflammationPseudomonas aeruginosaImmunotherapyPriming (immunology)TransplantationT lymphocyteChronic infectionCancer researchAntigen-presenting cellMedicineIL-2 receptorBiologyImmune systemCell biology
33Publications
15H-index
687Citations
Publications 36
Newest
#1Rosanna Mezzapelle (UniSR: Vita-Salute San Raffaele University)H-Index: 11
Last. Marco Bianchi (UniSR: Vita-Salute San Raffaele University)H-Index: 117
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Boosting antitumor immunity has emerged as a powerful strategy in cancer treatment. While releasing T-cell brakes has received most attention, tumor recognition by T cells is a pre-requisite. Radiotherapy and certain cytotoxic drugs induce the release of damage-associated molecular patterns, which promote tumor antigen cross-presentation and T-cell priming. Antibodies against the "do not eat me" signal CD47 cause macrophage phagocytosis of live tumor cells and drive the emergence of antitumor T ...
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#1Lien De BeckH-Index: 1
Last. Ken Maes
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#1Marco CatucciH-Index: 1
#2Veronica BassoH-Index: 15
Last. Anna MondinoH-Index: 29
view all 12 authors...
Background Adoptive T cell therapy (ACT) has become a promising option for cancer patients. While tumor-infiltrating lymphocytes were initially exploited as a source of tumor reactive lymphocytes, T cells genetically redirected to the tumor by TCR/CAR gene transfer are now in clinical validation. In the case of solid tumors, unfavorable immunosuppressive microenvironments remain recognized barriers to therapeutic efficacy. We have recently reported that the therapeutic activity of ACT against po...
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#1Anna GasparriH-Index: 22
#2Angelina SacchiH-Index: 19
Last. Flavio CurnisH-Index: 32
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: The clinical use of interleukin-12 (IL12), a cytokine endowed with potent immunotherapeutic anticancer activity, is limited by systemic toxicity. The hypothesis is addressed that gold nanoparticles tagged with a tumor-homing peptide containing isoDGR, an αvβ3-integrin binding motif, can be exploited for delivering IL12 to tumors and improving its therapeutic index. To this aim, gold nanospheres are functionalized with the head-to-tail cyclized-peptide CGisoDGRG (Iso1) and murine IL12. The resu...
3 CitationsSource
#1Giovanni GambiH-Index: 1
Last. Anna MondinoH-Index: 29
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Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a number of tumor suppressor genes (TSG) via molecular mechanisms that remain to be understood. Using nucleophosmin-anaplastic lymphoma kinase–positive (NPM-ALK+) anaplastic large-cell lymphoma (ALCL) as model system, we found in cells and patient...
12 CitationsSource
#1Karolina PilipowH-Index: 7
#2Veronica BassoH-Index: 15
Last. Anna MondinoH-Index: 29
view all 4 authors...
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#1Angela Elia (UniSR: Vita-Salute San Raffaele University)H-Index: 8
#1Angela Rita EliaH-Index: 12
Last. Matteo BelloneH-Index: 38
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Purpose: Irregular blood flow and endothelial cell anergy, which characterize many solid tumors, hinder tumor infiltration by cytotoxic T lymphocytes (CTLs). This confers resistance to cancer immunotherapy with monoclonal antibodies directed against regulatory pathways in T lymphocytes (i.e., immune checkpoint blockade, ICB). We investigated whether NGR-TNF, a TNF derivative capable of targeting the tumor vasculature, and improving intra-tumor infiltration by activated CTLs, could sensitize tumo...
16 CitationsSource
#1Teresa Manzo (UniSR: Vita-Salute San Raffaele University)H-Index: 4
#2Tabea Sturmheit (UniSR: Vita-Salute San Raffaele University)H-Index: 3
Last. Anna MondinoH-Index: 29
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Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such effects could be reproduced in autologous settings by TCR gene-engineered lymphocytes. We report that T cells redirected either to a broadly expressed Y-encoded minor H antigen or to a tumor-associated antigen, although poorly effective if individually transferred, w...
16 CitationsSource
#1Lorenza SpagnuoloH-Index: 6
#2Maura De SimoneH-Index: 5
Last. Alessandra BragonziH-Index: 33
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The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection
8 CitationsSource
#1Denise Drago (NIHR: National Institute for Health Research)H-Index: 1
#2Veronica BassoH-Index: 15
Last. Stefano Pluchino (NIHR: National Institute for Health Research)H-Index: 53
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Background Neural stem cells (NSCs) display tissue trophic and immune modulatory therapeutic activities after transplantation in central nervous system disorders. The intercellular interplay between stem cells and target immune cells is increased in NSCs exposed to inflammatory cues. Here, we hypothesize that inflammatory cytokine signalling leads to metabolic reprogramming of NSCs regulating some of their immune modulatory effects.
16 CitationsSource