Zhigang Zhang
Northeast Agricultural University
Internal medicineEndocrinologyReceptorChemistryApoptosisLuteolinOxidative stressLiver injuryResveratrolAntioxidantKidneyArsenic trioxideLung injuryArsenicCancer researchGlutathioneBiochemistrySignal transductionMedicineBiologyPharmacology
56Publications
24H-index
1,235Citations
Publications 59
Newest
#1Siyu Li (NEAU: Northeast Agricultural University)H-Index: 17
#2Bing Han (NEAU: Northeast Agricultural University)H-Index: 10
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through the food chain. However, it is unknown that the detailed mechanism of reproductive disorder induced by inorganic mercury in male mice to date. This study investigated the toxicological effect of mercuric chloride (HgCl2 ) exposure on reproductive system in male mice. Male Kunming mice received normal saline daily or HgCl2 (3 mg/kg bodyweight) by intraperitoneal injection for a week. The reproductive fu...
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#1Pengfei WuH-Index: 7
#2Bing HanH-Index: 10
Last. Zhigang ZhangH-Index: 24
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#1Xinyue Xu (NEAU: Northeast Agricultural University)H-Index: 1
#2Zhongxian Yu (Changchun University)
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Abstract null null Inorganic mercury is a ubiquitous toxic pollutant in the environment. Exposure to inorganic mercury can cause various poisonous effects, including kidney injury. However, no safe and effective treatment for kidney injury caused by inorganic mercury has been found and used. Luteolin (Lut) possesses various beneficial bioactivities. Here, our research aims to investigate the protective effect of Lut on renal injury induced by mercury chloride (HgCl2) and identify the underlying ...
1 CitationsSource
#1Ning Deng (NEAU: Northeast Agricultural University)H-Index: 3
#2Huijie Jiang (NEAU: Northeast Agricultural University)H-Index: 9
Last. Zhanjun Lv (NEAU: Northeast Agricultural University)H-Index: 12
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Deltamethrin (DLM) is a broad-spectrum and effective pyrethroid insecticide. However, DLM has good residual activity on most surfaces and many insects, so it poses a threat to the environment and health of animals and human. Exposure to DLM can cause kidney injury, but the mechanism is not well understood. Therefore, we investigated the possible mechanism of quail kidney injury induced by chronic exposure to different doses of DLM for 12 weeks. The results showed that chronic exposure to DLM ind...
4 CitationsSource
#1Biqi Han (NEAU: Northeast Agricultural University)H-Index: 2
#2Zhanjun Lv (NEAU: Northeast Agricultural University)H-Index: 12
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Mercury is widely used in industry and has caused global environmental pollution. Inorganic mercury accumulates in the body causes damage to many organs, and the kidney is the most susceptible to the toxic effects of mercury. However, the underlying specific molecular mechanism of renal injury induced by inorganic mercury remains unclear at the cellular level. Therefore, in order to understand its molecular mechanism, we used in vitro method. We established experimental models by treating human ...
1 CitationsSource
#1Xiaoqiao Wang (NEAU: Northeast Agricultural University)H-Index: 7
#2Zhanjun Lv (NEAU: Northeast Agricultural University)H-Index: 12
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Dibutyl phthalate (DBP)-an organic pollutant-is ubiquitous in the environment. DBP as an immune adjuvant is related to the development of multiple allergic diseases. However, the current research involving DBP-induced pulmonary toxicity remains poorly understood. Therefore, this research aimed to explore the adverse effect and potential mechanism of DBP exposure on the lungs in rats. In our study, ovalbumin was used to build a rat model of allergic airway inflammation to study any harmful effect...
2 CitationsSource
#1Jiayi LiH-Index: 8
#2Huijie JiangH-Index: 9
Last. Zhigang ZhangH-Index: 24
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Abstract Deltamethrin is the most common type II synthetic pyrethroid insecticide, and has posed widespread residues to environment. However, whether deltamethrin has potential toxic effects on quail cerebrum remains greatly obscure. Accordingly, we investigated the impact of chronic exposure to deltamethrin on oxidative stress and apoptosis in quail cerebrum. Quails upon 12-week exposure of deltamethrin (0, 15, 30, or 45 mg/kg body weight intragastric administration) were used as a cerebrum inj...
10 CitationsSource
#1Bing Han (NEAU: Northeast Agricultural University)H-Index: 10
#2Xiaoqiao Wang (NEAU: Northeast Agricultural University)H-Index: 7
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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ABSTRACT Graphitized multi-walled carbon nanotubes (GMWCNTs) are a new type of nanomaterial. Recently, their production and application in biological medicine have grown rapidly. However, GMWCNTs may cause adverse health effects, including the common occupational disease of pulmonary fibrosis. Pulmonary fibrosis is a serious progressive disease that often leads to lung failure, high mortality, and disability, and there is no effective therapy currently available. Therefore, identifying new bioma...
6 CitationsSource
#1Qingyue Yang (NEAU: Northeast Agricultural University)H-Index: 9
#2Bing Han (NEAU: Northeast Agricultural University)H-Index: 10
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Abstract Introduction Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates the structure and function of most proteins in a variety of ways. However, the hepatotoxicity of Cr(VI) and whether it is related to deacetylation remains largely unknown. Objectives We aimed to explore the link between the deacetylation of silent information regulator two ortholog 1 (Sirt1) and hepatotoxicity induced by Cr(VI) exposu...
8 CitationsSource
#1Daqian Yang (NEAU: Northeast Agricultural University)H-Index: 8
#2Qingyue Yang (NEAU: Northeast Agricultural University)H-Index: 9
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 24
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Abstract Hexavalent chromium (Cr(VI)), the most toxic valence state of chromium, is widely present in industrial effluents and wastes. Although previous study has reported that Cr(VI) can cause cytomembrane structure impairment by aggravating lipid peroxidation in the heart, the detailed mechanism of Cr(VI)-induced heart dysfunction is still unclear. Sesn2, a novel antioxidant and stress-inducible molecule, is evidenced to protect against various cardiometabolic diseases such as atherosclerosis ...
17 CitationsSource