Lin Sun
Northeast Normal University
PolysaccharideChemistrySize-exclusion chromatographySide chainArabinoseGlucanSugarGalactoseGalactanArabinogalactanRhamnoseGinsengPectinTLR2Lymphocyte proliferationChromatographySecretionEnzymatic hydrolysisBiochemistryMolecular massGel permeation chromatographyHydrolysis
32Publications
14H-index
577Citations
Publications 32
Newest
#1Xin Ning (Northeast Normal University)H-Index: 1
#2Ying Liu (Northeast Normal University)
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 9 authors...
Abstract Two pectic polysaccharides (WRSP-A2b and WRSP-A3a) have been obtained from Radix Sophorae Tonkinensis and comparatively investigated in terms of their physical properties and antioxidant activities. Monosaccharide composition, FT-IR, NMR and enzymatic analyses indicate that both WRSP-A2b (13.6 kDa) and WRSP-A3a (44.6 kDa) consist of homogalacturonan (HG), rhamnogalacturonan I (RG-I) and rhamnogalacturonan II (RG-II) domains, with mass ratios of 0.9:1.8:1 and 2.3:2.9:1, respectively. The...
Source
#1Yunhe Qu (Northeast Normal University)H-Index: 5
#2Xiaolin Zhao (Northeast Normal University)
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 7 authors...
The present study was designed to investigate the structure and immunomodulatory activity of a polysaccharide. A novel acidic β‑glucan (WCCP‑A‑b; molecular weight, 7.3 kDa) was purified from the fruiting bodies of the edible mushroom Cantharellus cibarius, which possesses high nutritional values. WCCP‑A‑b was composed primarily of glucose (89.7%) and glucuronic acid (8.8%). Methylation and nuclear magnetic resonance analysis suggested that WCCP‑A‑b contained β‑D‑1,6‑glucan as its main chain, whi...
Source
#1Liangnan Cui (Northeast Normal University)H-Index: 3
#2Lei Chen (Northeast Normal University)H-Index: 3
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 9 authors...
Abstract A neutral polysaccharide fraction (WGFPN) was isolated from Panax ginseng flowers. Monosaccharide composition and HPSEC-MALLS-RI (high-performance size exclusion chromatography coupled with multi-angle laser light scattering detector and refractive index detector) analyses showed WGFPN was a heterogalactan with a molecular weight of 11.0 kDa. Methylation, 1D/2D NMR (nuclear magnetic resonance) spectra and enzymatic hydrolysis methods were used to characterize the structure of WGFPN. It ...
2 CitationsSource
#1Lei Chen (Northeast Normal University)H-Index: 3
#2Miao Hao (Northeast Normal University)H-Index: 4
Last. Yifa Zhou (Northeast Normal University)H-Index: 29
view all 7 authors...
Abstract Heat-modified citrus pectin, a water-soluble indigestible polysaccharide fiber derived from citrus fruits and modified by temperature treatment, has been reported to exhibit anticancer effects. However, the bioactive fractions and their mechanisms remain unclear. In this current study, we isolated an active compound, trans-4,5-dihydroxy-2-cyclopentene-l-one (DHCP), from heat-treated citrus pectin, and found that is induces cell death in colon cancer cells via induction of mitochondrial ...
Source
#1Siwen Yang (Northeast Normal University)H-Index: 5
#2Yunhe Qu (Northeast Normal University)H-Index: 5
Last. Yuying Fan (Northeast Normal University)H-Index: 13
view all 7 authors...
Insufficient pancreatic β-cell or insulin-producing β-cell are implicated in all types of diabetes mellitus. Our previous studies showed bee pollen polysaccharide RBPP-P improves insulin resistance in type 2 diabetic mice by inhibiting liver fat deposition. However, its potential of regulating β-cell function and integrity is not fully known. Herein, we observed that β-cell proliferation (n = 10), insulin synthesis (n = 5, p = 0.01684) and insulin incretion (n = 5, p = 0.02115) were intensely ac...
Source
#1Hairong Cheng (Northeast Normal University)H-Index: 13
#2Lin Sun (Northeast Normal University)H-Index: 14
Last. Yifa Zhou (Northeast Normal University)H-Index: 29
view all 8 authors...
Abstract Tumor-associated macrophages (TAMs) with an M2-like phenotype have been linked to immunosuppression and resistance to chemotherapies of cancer, thus targeting TAMs has been an attractive therapeutic strategy to cancer immunotherapy. We have reported that the β-D-(1→6) glucan (AAMP-A70) isolated from Amillariella Mellea could promote macrophage activation. The present study showed that the β-1,6-glucan could promote the transformation of M2-like macrophages to M1-like phenotype and inhib...
2 CitationsSource
#1Huimin Shi (Northeast Normal University)H-Index: 3
#2Jialei Xu (Northeast Normal University)H-Index: 2
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 6 authors...
Abstract In this study, we report the development of an efficient protocol in the preparation of linear arabino-oligosaccharides derived from sugar beet arabinan. By optimizing hydrolytic conditions and separation on tandem Bio-Gel P4 columns, we obtained arabino-oligosaccharides with various degrees of polymerization (DP) from 2 to 15. All of these α-1,5-linked arabino-oligosaccharides are highly pure (>95%) as determined by HPAEC, MALDI-TOF mass spectrometry and 13C NMR spectroscopy. Due to th...
1 CitationsSource
#1Mi Kaythi Chan (Northeast Normal University)H-Index: 1
#2Yang Yu (Northeast Normal University)H-Index: 2
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 7 authors...
Abstract Panax notoginseng is a widely used traditional Chinese medicine and has extensive pharmacological effects. In this work, water-soluble polysaccharides from Panax notoginseng were isolated and fractionated. One starch-like polysaccharide (PNPN) and six pectin fractions (PNPA-1A, PNPA-1B, PNPA-2A, PNPA-2B, PNPA-3A and PNPA-3B) were obtained. Monosaccharide composition, enzymatic hydrolysis, nuclear magnetic resonance and methylation analysis were combined to characterize their structures....
4 CitationsSource
#1Gang Yao (Northeast Normal University)H-Index: 1
#2Jialei Xu (Northeast Normal University)H-Index: 2
Last. Lin Sun (Northeast Normal University)H-Index: 14
view all 7 authors...
Bupleurum chinense DC, a traditional medicinal plant in China that has many pharmacological effects, contains polysaccharide as one of its active components. In this study, we isolated and structur...
1 CitationsSource
#1Siwen Yang (Northeast Normal University)H-Index: 5
#2Yunhe Qu (Northeast Normal University)H-Index: 5
Last. Yuying Fan (Northeast Normal University)H-Index: 13
view all 9 authors...
Insulin resistance is the main cause of type 2 diabetes, fatty liver and obesity. Our previous study found mushroom polysaccharides have improved insulin resistance in vitro, but the underlying mechanisms were still unknown. Thus, we investigate the hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and the mechanisms. The total polysaccharide (AGRP) and the neutral polysaccharide (AGRP-N) enhance insulin-stimulated glucose uptake in autophagy-dependent manner on ...
9 CitationsSource