Annette Schmitt-Graeff
University of Freiburg
HaematopoiesisPathologyCytotoxic T cellImmunologyBiopsyT cellHematopoietic stem cell transplantationLeukemiaMyeloid leukemiaMyeloidLymphomaGraft-versus-host diseaseBone marrowMyelofibrosisTransplantationCancer researchMedicineBiologyImmune systemGastroenterology
Publications 174
#1Claudia Wehr (University of Freiburg)H-Index: 11
#2Leonora Houet (University of Freiburg)
Last. Annette Schmitt-Graeff (University of Freiburg)H-Index: 38
view all 13 authors...
PURPOSE Common variable immune deficiency (CVID) confers an increased risk of lymphoid neoplasms, but reports describing the precise WHO specification of the lymphoma subtypes and their immunological environment are lacking. We therefore classified lymphomas-occurring in a cohort of 21 adult CVID patients during a 17-year period at our center-according to the 2016 WHO classification and characterized the local and systemic immunological context RESULTS: The median time between the onset of CVID ...
#1Javier I. Muñoz-González (University of Salamanca)H-Index: 7
Last. Alberto Orfao (University of Salamanca)H-Index: 74
view all 36 authors...
BACKGROUND Several risk stratification models have been proposed in recent years for systemic mastocytosis but have not been directly compared. Here we designed and validated a risk stratification model for progression-free survival (PFS) and overall survival (OS) in systemic mastocytosis on the basis of all currently available prognostic factors, and compared its predictive capacity for patient outcome with that of other risk scores. METHODS We did a retrospective prognostic modelling study bas...
2 CitationsSource
#1Franziska M. Uhl (University of Freiburg)H-Index: 6
#2Sophia Chen (University of Freiburg)H-Index: 6
Last. Robert Zeiser (University of Freiburg)H-Index: 46
view all 25 authors...
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production. Functional studies in multiple mouse models of leukemia showed that leukemia-derived lactic acid (LA) interfered with T cell glycolysis and proliferation. Mechanistically, LA reduced intracellular pH in T cells, led to lower transcription of glycolys...
4 CitationsSource
#1Johana Norona (University Medical Center Freiburg)H-Index: 1
#2Petya Apostolova (University Medical Center Freiburg)H-Index: 10
Last. Robert Zeiser (University Medical Center Freiburg)H-Index: 46
view all 27 authors...
Acute graft-versus-host disease (GVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). While currently used GVHD treatment regimens target the donor immune system, we explored here an approach that aims at protecting and regenerating Paneth cells (PC) and intestinal stem cells (ISC). Glucagon-like-peptide-2 (GLP-2) is an enteroendocrine tissue hormone, produced by intestinal L-cells. We observed that acute GVHD reduced intestinal GLP-2 levels in...
3 CitationsSource
#1Wolfgang Kreisel (University of Freiburg)H-Index: 23
#2Denise Schaffner (University of Freiburg)H-Index: 5
Last. Peter Deibert (University of Freiburg)H-Index: 26
view all 7 authors...
2 CitationsSource
#1Eileen Haring (University of Freiburg)H-Index: 2
#2Franziska M. Uhl (University of Freiburg)H-Index: 6
Last. Petya Apostolova (University of Freiburg)H-Index: 10
view all 20 authors...
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and facilitate malignancy relapse. Therefore, novel approaches that protect and regenerate injured tissues without impeding the donor immune system are needed. Bile acids regulate multiple cellular processes and are in close contact with the intestinal epi...
2 CitationsSource
#1Stefanie Kreutmair (University of Freiburg)H-Index: 3
#2Miriam Erlacher (DKFZ: German Cancer Research Center)H-Index: 20
Last. Anna Lena Illert (University of Freiburg)H-Index: 8
view all 34 authors...
Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function, and cancer susceptibility. Diagnosis of IBMFS presents a major challenge due to the large variety of associated phenotypes, and novel, clinically relevant biomarkers are urgently needed. Our study identified nuclear interaction partner of ALK (NIPA) as an IBMFS gene, as it is significantly downregulated in a distinct subset of myelodysplas...
1 CitationsSource
#1Tsubasa Watanabe (University of Freiburg)H-Index: 2
#2Elke Firat (University of Freiburg)H-Index: 17
Last. Gabriele Niedermann (DKFZ: German Cancer Research Center)H-Index: 31
view all 15 authors...
Radiotherapy can elicit abscopal effects in non-irradiated metastases, particularly under immune checkpoint blockade (ICB). We report on two elderly patients with oligometastatic melanoma treated with anti-PD-1 and stereotactic body radiation therapy (SBRT). Before treatment, patient 1 showed strong tumor infiltration with exhausted CD8+ T cells and high expression of T cell-attracting chemokines. This patient rapidly mounted a complete response, now ongoing for more than 4.5 years. Patient 2 ex...
3 CitationsSource